Deciphering the Antibacterial Mechanism of Hollow Sphere Metal–Organic Frameworks against Staphylococcus aureus and Its Application in Wound Healing
Chemistry of Materials,
Год журнала:
2025,
Номер
unknown
Опубликована: Март 7, 2025
Staphylococcus
aureus
infection
and
antimicrobial
resistance
(AMR)
to
antibiotics
are
two
significant
factors
that
pose
escalating
threats
public
health,
potentially
leading
persistent
pain
or
even
death.
Consequently,
there
is
an
urgent
need
for
the
development
of
alternative
antibacterial
materials.
In
this
study,
we
have
successfully
developed
a
biocompatible
nanosystem
based
on
hollow
spherical
zeolitic
imidazolate
framework-67
(ZIF-67
HS),
which
exhibits
remarkable
bactericidal
efficacy
against
Gram-positive
S.
both
in
vitro
vivo.
Importantly,
our
findings
demonstrate
prolonged
exposure
subminimum
inhibitory
concentrations
ZIF-67
HS
does
not
induce
secondary
as
observed
with
conventional
antibiotics;
instead,
it
maintains
sustained
susceptibility
toward
antibiotic-resistant
strains.
Multiomics
analyses
(including
transcriptomics,
metabolomics,
metalomics)
indicated
regulates
95
genes,
261
metabolites,
2
metal
elements
aureus.
Through
bioinformatics
analysis
combination
bioassays,
demonstrated
disrupted
multiple
essential
pathways
pathogen,
including
amino
acid
metabolism,
iron
membrane
transport,
reactive
oxygen
species
(ROS),
pathways.
Our
suggest
induces
bacterial
death
through
mechanisms
rather
than
single
target
highlight
its
long-lasting
properties.
This
study
presents
valuable
insights
into
potential
nanobiomedicine
eradicating
bacteria
elucidates
related
molecular
mechanism.
Язык: Английский
Recent Advancements in Lung Cancer Metastasis Prevention Based on Nanostrategies
Advanced Science,
Год журнала:
2025,
Номер
unknown
Опубликована: Март 26, 2025
Metastasis
is
the
leading
cause
of
death
in
patients
with
lung
cancer.
Multidisciplinary
comprehensive
treatments
(MDT),
including
surgery,
chemotherapy,
radiotherapy,
gene-targeted
therapy,
immunotherapy,
antibody-drug
conjugate
(ADC),
natural
products,
etc.,
have
been
currently
used
for
cancer
metastasis.
The
MDT
model
has
shown
promising
efficacy
against
metastasis
clinical
practice.
However,
these
therapies
some
limitations,
such
as
unusual
toxic
side
effects,
drug
resistance,
limited
indications,
and
high
costs.
Therefore,
emerging
technological
platforms
are
imperative
to
overcome
bottlenecks.
Nanomedicine
can
be
prepare
efficient
delivery
systems
owing
its
good
biocompatibility,
targeting,
responsive
release,
multidrug
codelivery
plays
an
important
role
synergistic
antimetastasis
because
optical,
acoustic,
electrical,
thermal,
magnetic
functions.
This
review
analyses
limitations
model,
briefly
outlines
advantages
nanotechnology,
introduces
nanodrug
systems,
summarizes
nanostrategies
based
on
invasion-metastasis
cascade
process,
provides
a
summary
prospects
challenges
translation
nanomedicines.
Язык: Английский