The role of RGC degeneration in the pathogenesis of glaucoma DOI

Zhibo Si,

Yuhang Fan, Mingxuan Wang

и другие.

International Journal of Biological Sciences, Год журнала: 2024, Номер 21(1), С. 211 - 232

Опубликована: Дек. 11, 2024

Glaucoma is a neurodegenerative disorder marked by the loss of retinal ganglion cells (RGCs) and axonal degeneration, resulting in irreversible vision impairment. While intraocular pressure (IOP) presently acknowledged as sole modifiable risk factor, sensitivity RGCs to IOP varies among individuals. Consequently, progressive may ensue even when effectively managed. This review consolidates current knowledge regarding pathogenesis glaucoma various diseases. It delves into mechanisms underlying RGC transsynaptic degeneration defects from pathophysiological standpoint, it elucidates alterations visual pathway throughout progression disease. Furthermore, article outlines neuroprotective nerve regeneration strategies aimed at restoration patients, offers insights for clinical management condition, investigates prospective avenues gene therapy.

Язык: Английский

Self‐Assembly Hypoxic and ROS Dual Response Nano Prodrug as a New Therapeutic Approach for Glaucoma Treatments DOI Creative Commons
Xuezhi Zhou, Rong Rong,

Ganghao Liang

и другие.

Advanced Science, Год журнала: 2024, Номер 11(41)

Опубликована: Сен. 4, 2024

Abstract Glaucoma is an irreversible blinding eye disease characterized by retinal ganglion cell (RGC) death.Previous studies have demonstrated that protecting mitochondria and activating the CaMKII/CREB signaling pathway can effectively protect RGC axon. However, currently treatments are often unsatisfactory, pathogenesis of glaucoma requires further elucidation. In this study, a ROS‐responsive dual drug conjugate (OLN monomer) first designed simultaneously bonds nicotinamide oleic acid. The self‐assembled into nanoparticles (uhOLN‐NPs) through aggregation multiple micelles possesses ROS scavenging capability. Then, polymer with hypoxic response function designed, which encapsulates uhOLN‐NPs to form responses (HOLN‐NPs). Under hypoxia in RGCs, azo bond HOLN‐NPs breaks releases uhOLN‐NPs. Meanwhile, under high conditions, thioketone broke, leading dissociation nano‐prodrug. released acid co‐scavenge activate pathway, RGCs. exhibit significantly superior protective effect on R28 cells glutamate models glaucoma. accumulation RGCs lead significant inhibition apoptosis axonal damage vivo. Notably, provide new therapeutic approach for patients neurodegenerative disease.

Язык: Английский

Процитировано

4
Preserving blood-retinal barrier integrity: a path to retinal ganglion cell protection in glaucoma and traumatic optic neuropathy DOI Creative Commons

Lai-Yang Zhou,

Zhen-Gang Liu,

Sun Yong-quan

и другие.

Cell Regeneration, Год журнала: 2025, Номер 14(1)

Опубликована: Апрель 2, 2025

Retinal ganglion cells (RGCs) are the visual gateway of brain, with their axons converging to form optic nerve, making them most vulnerable target in diseases such as glaucoma and traumatic neuropathy (TON). In both diseases, disruption blood-retinal barrier(BRB) is considered an important mechanism that accelerates RGC degeneration hinders axon regeneration. The BRB consists inner barrier (iBRB) outer (oBRB), which maintained by endothelial cells(ECs), pericytes(PCs), retinal pigment epithelial (RPE), respectively. Their functions include regulating nutrient exchange, oxidative stress, immune microenvironment. However, TON, structural functional integrity severely damaged due mechanical inflammatory reactions, metabolic disorders. Emerging evidence highlights leads heightened vascular permeability, cell infiltration, sustained chronic inflammation, creating a hostile microenvironment for survival. Furthermore, dynamic interplay imbalance among ECs, PCs, glial within neurovascular unit (NVU) pivotal drivers destruction, exacerbating apoptosis limiting nerve intricate molecular cellular mechanisms underlying these processes underscore BRB's critical role TON pathophysiology while offering compelling foundation therapeutic strategies targeting repair stabilization. This review provides crucial insights lays robust groundwork advancing research on neural regeneration innovative protective strategies.

Язык: Английский

Процитировано

0
Advances in the application of smart materials in the treatment of ophthalmic diseases DOI
Yida Liu,

Hong Ren,

Zhenkai Wu

и другие.

Biomaterials, Год журнала: 2025, Номер unknown, С. 123316 - 123316

Опубликована: Апрель 1, 2025

Язык: Английский

Процитировано

0
The role of RGC degeneration in the pathogenesis of glaucoma DOI

Zhibo Si,

Yuhang Fan, Mingxuan Wang

и другие.

International Journal of Biological Sciences, Год журнала: 2024, Номер 21(1), С. 211 - 232

Опубликована: Дек. 11, 2024

Glaucoma is a neurodegenerative disorder marked by the loss of retinal ganglion cells (RGCs) and axonal degeneration, resulting in irreversible vision impairment. While intraocular pressure (IOP) presently acknowledged as sole modifiable risk factor, sensitivity RGCs to IOP varies among individuals. Consequently, progressive may ensue even when effectively managed. This review consolidates current knowledge regarding pathogenesis glaucoma various diseases. It delves into mechanisms underlying RGC transsynaptic degeneration defects from pathophysiological standpoint, it elucidates alterations visual pathway throughout progression disease. Furthermore, article outlines neuroprotective nerve regeneration strategies aimed at restoration patients, offers insights for clinical management condition, investigates prospective avenues gene therapy.

Язык: Английский

Процитировано

0