Machine Learning‐Assisted High‐Throughput Screening of Nanozymes for Ulcerative Colitis

Advanced Materials, Год журнала: 2025, Номер unknown

Опубликована: Янв. 12, 2025

Ulcerative colitis (UC) is a chronic gastrointestinal inflammatory disorder with rising prevalence. Due to the recurrent and difficult-to-treat nature of UC symptoms, current pharmacological treatments fail meet patients' expectations. This study presents machine learning-assisted high-throughput screening strategy expedite discovery efficient nanozymes for treatment. Therapeutic requirements, including antioxidant property, acid stability, zeta potential, are quantified predicted by using learning model. Non-quantifiable attributes, intestinal barrier repair efficacy biosafety, assessed via screening. Feature significance analysis, sure independence screening, sparsifying operator symbolic regression reveal high-dimensional structure-activity relationships between material features therapeutic needs. SrDy

Язык: Английский

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Nanomaterials in cancer immunotherapy: targeting cancer-associated fibroblasts

Cancer Nanotechnology, Год журнала: 2025, Номер 16(1)

Опубликована: Янв. 17, 2025

Emphasizing the significance of cancer-associated fibroblasts (CAFs), non-malignant yet pivotal players within tumor microenvironment (TME), this review illuminates role inflammatory subtype (iCAF) as catalysts in cancer proliferation, metastasis, and therapeutic resistance. Given their paramount importance, targeting CAFs emerges a robust strategy evolving landscape immunotherapy. Nanomaterials, distinguished by unique features malleability, hold considerable promise biomedicine, especially precision-oriented domain therapy. Their aptitude for modulating immune responses, amplifying drug efficacy through precise delivery, discerningly focusing on cells TME situates nanomaterials formidable tools to transcend boundaries set conventional treatments. This scrutinizes convoluted interplay among CAFs, cells, TME. It further showcases widely utilized management. We underscore potential nanoscale delivery systems directed at underscoring transformative power revolutionizing therapies, enhancing precision, culminating improved patient outcomes.

Язык: Английский

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Emerging engineered nanozymes: current status and future perspectives in cancer treatments

Nanoscale Advances, Год журнала: 2025, Номер unknown

Опубликована: Янв. 1, 2025

Composite nanozymes are composed of enzymes with similar or different catalytic capabilities and have higher activity than a single enzyme. In recent years, composite emerged as novel nanomaterial platforms for multiple applications in various research fields, where they used to produce oxygen, consume glutathione, toxic reactive oxygen species (ROS) cancer therapy. The therapeutic approach using is known chemo-dynamic therapy (CDT). Some also show special photothermal conversion effects, enabling them be combined pioneering treatments, such photodynamic (PDT), (PTT) sonodynamic (SDT), enhance the anti-cancer effects. this study, classification performances reviewed, along their advantages synthesis methods. Furthermore, treatment cancers emphasized, prospective challenges future discussed.

Язык: Английский

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Ultrasmall platinum single-atom enzyme alleviates oxidative stress and macrophage polarization induced by acute kidney ischemia–reperfusion injury through inhibition of cell death storm

Journal of Nanobiotechnology, Год журнала: 2025, Номер 23(1)

Опубликована: Апрель 27, 2025

Acute kidney injury (AKI), characterized by a rapid decline in renal function, is associated with impaired mitochondrial function and excessive reactive oxygen species (ROS). Therefore, the exploration of ROS scavengers provides promising new opportunities for prevention treatment AKI mitigating oxidative stress. Here, we construct an ultrasmall platinum single-atom enzyme (Pt/SAE) multiple antioxidant activities to protect against acute ischemia-reperfusion (I/R) injury. Pt/SAE not only mimics superoxide dismutase catalase convert anion into water oxygen, but also exhibits impressive hydroxyl radical scavenging capacity, thereby reducing pro-inflammatory macrophage levels preventing inflammation. Furthermore, reduces accumulation Z-form DNA, which excessively accumulates following I/R damage, thus decreasing its interaction Z-DNA binding protein 1, consequently progression PANoptosis Additionally, downregulation induced suppresses lipid peroxidation, return ferroptosis I/R. Both vitro vivo experiments confirm that effectively mitigates inflammatory cell infiltration promotes shift polarization from M1-like M2-like subtype. This study information development novel SAEs as viable method AKI.

Язык: Английский

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Mitoxantrone‐Encapsulated ZIF‐8 Enhances Chemo‐Immunotherapy via Amplified Immunogenic Cell Death

Advanced Science, Год журнала: 2025, Номер unknown

Опубликована: Фев. 14, 2025

Abstract Chemo‐immunotherapy, combining systemic chemotherapeutic drugs and immune checkpoint blockers, is a promising paradigm in cancer treatment. However, challenges such as limited induction of responses toxicity have hindered its clinical applications. Here, zeolite imidazolate framework‐8 (ZIF‐8) that encapsulates mitoxantrone (MIT), an cell death (ICD)‐inducing agent (MIT@ZIF‐8), synthesized using one‐pot aqueous‐phase process. ZIF‐8 serves dual‐functional nanomaterial for chemo‐immunotherapy: carrier to enhance tumor uptake MIT improved chemotherapy efficacy, pyroptosis inducer amplify MIT‐induced ICD augmented anti‐tumor responses. As result, vivo administration MIT@ZIF‐8 markedly inhibits growth both immunologically “hot” colon “cold” prostate cancer. Moreover, treatment increases the abundance cytotoxic CD8 + T cells reduces amount immunosuppressive regulatory tumors, thereby enhancing immunity sensitizing anti‐CTLA‐4 immunotherapy. In summary, offers highly translational approach chemo‐immunotherapy.

Язык: Английский

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Microenvironment‐Responsive Injectable Thermosensitive Hydrogel Incorporating Nanozymes for Synergistic Breast Cancer Therapy and Postsurgical Adjuvant Treatment

Advanced Functional Materials, Год журнала: 2025, Номер unknown

Опубликована: Фев. 23, 2025

Abstract Tumor recurrence and wound infection present significant challenges to patient recovery following surgery, underscoring the need for effective therapeutic strategies improve prognosis by mitigating these complications. This study introduces novel synthesis methods honeycomb‐like CuMnOx nanozymes CuO 2 nanoflowers with multienzymatic activity pH‐responsive properties. The enzymatic activities of can be regulated pH changes in tumor or microenvironments, while overcome limitation insufficient endogenous H O release ROS weakly acidic conditions. To realize their synergistic effects, nanozymes, along photothermal agent IR820, are co‐assembled into low‐melting point agarose solution, forming a thermosensitive nanozyme‐based hydrogel (CuMnOx@CuO @IR820 hydrogel, CMCI Gel), which facilitates controlled drug delivery exerts enhanced efficiency under low‐temperature therapy (LTPTT, <48 °C). In vitro vivo studies demonstrated that Gel effectively ablated cells range bacteria, including drug‐resistant bacteria like MRSA . Furthermore, it reduces inflammation, promotes vascular regeneration collagen deposition, accelerates healing. injectability thermosensitivity allow localized treatment, minimizing systemic side effects. Overall, benefits highlight as promising adjunctive prevent postsurgery infection.

Язык: Английский

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Catalytic Nanozyme: Unlocking new horizons in articular cartilage degeneration treatment

Coordination Chemistry Reviews, Год журнала: 2025, Номер 541, С. 216845 - 216845

Опубликована: Май 29, 2025

Язык: Английский

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A multichannel closed bipolar electrode-LED sensing array for simultaneous sensitive and visible detection of multiple tumor markers

Sensors and Actuators B Chemical, Год журнала: 2025, Номер unknown, С. 138071 - 138071

Опубликована: Май 1, 2025

Язык: Английский

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