Microfluidic Nanoparticle Separation for Precision Medicine
Advanced Science,
Год журнала:
2024,
Номер
unknown
Опубликована: Дек. 4, 2024
Abstract
A
deeper
understanding
of
disease
heterogeneity
highlights
the
urgent
need
for
precision
medicine.
Microfluidics,
with
its
unique
advantages,
such
as
high
adjustability,
diverse
material
selection,
low
cost,
processing
efficiency,
and
minimal
sample
requirements,
presents
an
ideal
platform
medicine
applications.
As
nanoparticles,
both
biological
origin
therapeutic
purposes,
become
increasingly
important
in
medicine,
microfluidic
nanoparticle
separation
proves
particularly
advantageous
handling
valuable
samples
personalized
This
technology
not
only
enhances
detection,
diagnosis,
monitoring,
treatment
accuracy,
but
also
reduces
invasiveness
medical
procedures.
review
summarizes
fundamentals
techniques
starting
examination
properties
essential
core
principles
that
guide
various
methods.
It
then
explores
passive,
active,
hybrid
techniques,
detailing
their
principles,
structures,
Furthermore,
contributions
to
advancements
liquid
biopsy
nanomedicine.
Finally,
it
addresses
existing
challenges
envisions
future
development
spurred
by
emerging
technologies
advanced
materials
science,
3D
printing,
artificial
intelligence.
These
interdisciplinary
collaborations
are
anticipated
propel
platformization
significantly
expanding
potential
Язык: Английский
How Traditional Chinese Medicine Can Play a Role In Nanomedicine? A Comprehensive Review of the Literature
International Journal of Nanomedicine,
Год журнала:
2025,
Номер
Volume 20, С. 6289 - 6315
Опубликована: Май 1, 2025
Traditional
Chinese
medicine
(TCM),
a
time-honored
practice
rooted
in
natural
therapeutics,
has
served
as
cornerstone
safeguarding
human
health
across
millennia,
aiding
disease
mitigation
and
life
vitality
preservation.
However,
many
TCM
active
ingredients
suffer
from
poor
solubility,
low
bioavailability,
uncertain
toxicity
weak
targeting
ability.
Nanomedicine
represents
modern
scientific
frontier,
emerging
the
precise
engineering
of
unique
nanoscale
characteristics,
with
extensive
applications
encompassing
targeted
therapeutic
delivery
diverse
biomedical
fields.
Although
nanomedicine
diverge
fundamentally
historical
origins
disciplinary
foundations,
growing
investigations
demonstrate
their
synergistic
potential.
In
this
review,
nanosized
been
revealed
an
innovative
strategy
significant
clinical
value.
Based
on
biological
activities
structural
characteristics
ingredients,
we
classify
them
into
two
categories:
nanostructured
formulations
for
nano-drug
systems
TCM.
A
systematic
comprehensive
analysis
preparations
specific
functions
to
classes
nanomedicines
is
highlighted.
Insights
advantage
are
also
introduced.
Subsequently,
treatment,
including
anti-cancer,
anti-inflammation
anti-bacterial
summarized.
Finally,
challenges
future
research
directions
emphasized,
aiming
offer
guidance
modernization
nanomedicines.
Язык: Английский
Small Extracellular Vesicles Orchestrate Cisplatin‐Induced Ototoxicity: Potential Biomarker and Targets Discovery
Advanced Science,
Год журнала:
2025,
Номер
unknown
Опубликована: Май 24, 2025
Abstract
Cisplatin‐induced
ototoxicity
remains
a
clinical
dilemma
with
limited
mechanistic
understanding
and
no
food
drug
administration
(FDA)‐approved
therapies.
Despite
emerging
roles
of
small
extracellular
vesicles
(sEV)
in
ototoxicity,
their
molecular
cargo
profiles
causal
to
cisplatin‐induced
are
unexplored.
This
study
systematically
investigates
sEV
derived
from
cochlear
explants
treated
cisplatin
(Cis‐sEV)
controls
(Ctrl‐sEV)
using
multi‐omics
profiling.
Through
RNA
sequencing,
83
differentially
expressed
microRNAs
(miRNAs)
identified
Cis‐sEV
compared
Ctrl‐sEV.
Notably,
mmu‐miR‐34a‐5p,
mmu‐miR‐140‐5p,
mmu‐miR‐15b‐5p,
mmu‐miR‐25‐3p,
mmu‐miR‐339‐5p
significantly
upregulation
Cis‐sEVs.
Predicted
target
pathways
these
miRNAs
enriched
apoptosis,
inflammation,
cellular
damage,
indicating
potential
involvement
damage.
LC‐MS/MS
analysis
reveals
90
upregulated
150
downregulated
proteins
Cis‐sEV,
many
involved
damage
response.
Specifically,
CLTC,
CCT2,
ANXA6,
HSPA8
uniquely
CLTC
ANXA6
exclusively
co‐localized
hair
cells
(HCs)
post‐cisplatin
exposure,
suggesting
that
originate
primarily
damaged
HCs.
Moreover,
may
serve
as
biomarker
for
verified
both
vitro
vivo
models.
provides
novel
insights
into
the
mechanisms
identifies
therapeutic
targets.
Язык: Английский