Self‐Adaptive Dynamic Hydrogel Disrupts Ironclad Defense to Augment Photothermal‐Catalytic Therapy Against Melanoma Recurrence and Promote Post‐Surgical Wound Healing DOI Open Access
Hai Zhu, Xinhao Peng, Yanzhuo Liu

и другие.

Advanced Functional Materials, Год журнала: 2025, Номер unknown

Опубликована: Март 20, 2025

Abstract Post‐surgical photothermal therapy for melanoma faces significant challenges including resistance, tumor recurrence, and wound healing. In response, a self‐adaptive hydrogel (VPHCh) is designed, synthesized from carboxymethyl chitosan, integrated with vanadium‐polydopamine (V‐PDA) nanoplatform, which significantly enhances both catalytic properties. The advanced effectively inhibits recurrence facilitates healing through the precise modulation of V‐PDA release dynamics. infection microenvironment, rapidly released, delivering outstanding effects. Furthermore, synergistic actions reactions, induces endoplasmic reticulum stress, disrupting Wnt/β‐catenin signaling pathway enhancing V 5+ ‐mediated glutathione depletion, thereby increasing cell sensitivity to ferroptosis. Importantly, lipid peroxidation during ferroptosis further degradation heat shock protein 90, markedly augmenting effects therapies. Additionally, within VPHCh enables controlled sustained V‐PDA, promoting proliferation, angiogenesis, M2 macrophage polarization, accelerating also exhibits remarkable antibacterial properties, inhibiting bacterial facilitating Consequently, this dynamically adaptive represents promising adjuvant in post‐surgical treatment, offering substantial potential inhibit accelerate

Язык: Английский

Self‐Adaptive Dynamic Hydrogel Disrupts Ironclad Defense to Augment Photothermal‐Catalytic Therapy Against Melanoma Recurrence and Promote Post‐Surgical Wound Healing DOI Open Access
Hai Zhu, Xinhao Peng, Yanzhuo Liu

и другие.

Advanced Functional Materials, Год журнала: 2025, Номер unknown

Опубликована: Март 20, 2025

Abstract Post‐surgical photothermal therapy for melanoma faces significant challenges including resistance, tumor recurrence, and wound healing. In response, a self‐adaptive hydrogel (VPHCh) is designed, synthesized from carboxymethyl chitosan, integrated with vanadium‐polydopamine (V‐PDA) nanoplatform, which significantly enhances both catalytic properties. The advanced effectively inhibits recurrence facilitates healing through the precise modulation of V‐PDA release dynamics. infection microenvironment, rapidly released, delivering outstanding effects. Furthermore, synergistic actions reactions, induces endoplasmic reticulum stress, disrupting Wnt/β‐catenin signaling pathway enhancing V 5+ ‐mediated glutathione depletion, thereby increasing cell sensitivity to ferroptosis. Importantly, lipid peroxidation during ferroptosis further degradation heat shock protein 90, markedly augmenting effects therapies. Additionally, within VPHCh enables controlled sustained V‐PDA, promoting proliferation, angiogenesis, M2 macrophage polarization, accelerating also exhibits remarkable antibacterial properties, inhibiting bacterial facilitating Consequently, this dynamically adaptive represents promising adjuvant in post‐surgical treatment, offering substantial potential inhibit accelerate

Язык: Английский

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