Frontiers in Cell and Developmental Biology, Год журнала: 2025, Номер 13

Опубликована: Фев. 26, 2025

Enhanced Drp1 activity mediates excessive mitochondrial fission, contributing to the onset and progression of various chronic diseases, including neurodegenerative, cardiovascular, metabolic disorders. Studies indicate that exercise mitigates dysfunction by modulating Drp1-related signaling targets, thereby inhibiting reducing fission. This, in turn, enhances function cellular metabolism. This review synthesizes current understanding structure activation mechanisms, analyzes effects interventions on Drp1-mediated fission different disease models improve common conditions. research deepens our insight into specific mechanisms Drp1-induced pathogenesis, offering new theoretical support practical guidance for as a non-pharmacological intervention strategy.

Язык: Английский