Advances in Illuminating Prostate Cancer with Emerging Phototherapies
annals of urologic oncology,
Год журнала:
2025,
Номер
unknown
Опубликована: Янв. 31, 2025
Prostate
cancer
is
a
worldwide
health
concern
in
men,
with
substantially
high
incidence
rate
and
advanced
metastatic
disease-related
mortality
rates.
Despite
advancements
diagnostics
treatment
options,
conventional
therapies
for
prostate
cancer,
including
surgery,
radiotherapy,
chemotherapy
androgen
deprivation
therapy,
face
limitations
such
as
resistance,
limited
precision
off-target
side-effects.
Hence,
identification
clinical
translation
of
novel
therapeutic
strategies
urgently
needed.
In
this
regard,
phototherapies,
photodynamic
therapy
(PDT)
photothermal
(PTT),
are
emerging
promising
options
addressing
the
challenges
associated
options.
Utilizing
near-infrared
(NIR)
light
to
selectively
target
cells,
these
approaches
spare
healthy
tissues.
PDT
employs
photosensitizers
produce
reactive
oxygen
species,
thereby
stimulating
anti-tumor
immune
responses,
disrupting
tumor
microvasculature
and/or
inducing
aopotitic
or
necrotic
cell
death.
contrast,
PTT
leverages
agents
generate
localized
hyperthermia,
achieving
effective
thermal
ablation
cells.
Recent
nanoparticle
technology
have
significantly
improved
efficacy
specificity
phototherapies.
Functionalized
nanoparticles,
those
targeting
prostate-specific
membrane
antigen
(PSMA),
enhance
delivery,
reducing
systemic
toxicity.
Combination
incorporating
modalities,
immunotherapy,
demonstrated
synergistic
effects,
leading
better
sensitization.
Preclinical
studies
underline
potential
multimodal
outcomes,
particularly
castration-resistant
cancer.
This
review
explores
recent
innovations
illuminating
their
combination
therapies,
global
burden.
Язык: Английский
Photoactivated Self‐Assembled Nanomicelles Integrating Mitophagy Inhibition to Enhance Pyroptosis for Cancer Immunotherapy
Advanced Functional Materials,
Год журнала:
2025,
Номер
unknown
Опубликована: Март 26, 2025
Abstract
Multimodal
therapy
often
demonstrates
superior
therapeutic
effects
compared
to
monotherapy.
Phototherapy
is
a
promising
approach
for
cancer
treatment,
as
it
can
induce
tumor
pyroptosis
and
activate
antitumor
immune
responses.
However,
mitochondrial
oxidative
stress
during
frequently
stimulates
protective
autophagy
in
cells,
thereby
seriously
impeding
the
progress
of
pyroptosis.
Therefore,
developing
that
enhances
through
inhibiting
critical
improving
treatment
efficacy.
In
this
study,
photoactivated
mitochondrial‐targeting
self‐assembled
nanomicelle
(
3M@C
)
integrates
an
aggregation‐induced
emission
photosensitizer
inhibitor
chloroquine
designed.
generate
both
type
I
II
reactive
oxygen
species
heat
under
light
exposure,
inducing
dysfunction
triggering
pyroptosis,
achieving
photodynamic
synergistic
photothermal
therapy.
Meanwhile,
inhibit
mitophagy,
further
enhance
effects,
vivo
experiments
demonstrate
strategy
exhibits
excellent
biosafety
significant
efficacy,
effectively
suppressing
growth.
addition,
method
nanomicelles
mitophagy
inhibition
providing
novel
photoimmunotherapy.
Язык: Английский