X-ray-Triggered Activation of Polyprodrugs for Synergistic Radiochemotherapy DOI
Yufei Cao, Min Zheng, Jiahong Shi

и другие.

Biomacromolecules, Год журнала: 2024, Номер 26(1), С. 579 - 590

Опубликована: Дек. 27, 2024

X-ray-induced photodynamic therapy (XPDT) can penetrate deeply into the tumor tissues to overcome disadvantage of conventional PDT. However, therapeutic efficacy XPDT in cancer is still restricted due insufficient reactive oxygen species (ROS) generation at a relatively low irradiation dosage. Herein, we present pH and ROS-responsive polyprodrug micelles load X-ray photosensitizer verteporfin (VP) as an ROS production enhancer. The block copolymer consisting hydrophilic poly(ethylene glycol) (PEG) well segments thioketal-linked camptothecin (CPT) methacrylate (CPTKMA) 2-(pentamethyleneimino)ethyl (PEMA) (PEG-b-P(CPTKMA-co-PEMA)) self-assemble aqueous solution encapsulate VP with high loading efficiency 67%. Inside tissues, zeta potential transform from neutral positive for promoted cellular internalization under acidity. Followed by dose 4 Gy, efficient presence triggers CPT release. VP-loaded finally ablate tumors efficiently via synergistic radiochemotherapy deep penetration inside enhancement, triggered Consequently, this promising strategy represents robust modality enhanced cancers.

Язык: Английский

X-ray-Triggered Activation of Polyprodrugs for Synergistic Radiochemotherapy DOI
Yufei Cao, Min Zheng, Jiahong Shi

и другие.

Biomacromolecules, Год журнала: 2024, Номер 26(1), С. 579 - 590

Опубликована: Дек. 27, 2024

X-ray-induced photodynamic therapy (XPDT) can penetrate deeply into the tumor tissues to overcome disadvantage of conventional PDT. However, therapeutic efficacy XPDT in cancer is still restricted due insufficient reactive oxygen species (ROS) generation at a relatively low irradiation dosage. Herein, we present pH and ROS-responsive polyprodrug micelles load X-ray photosensitizer verteporfin (VP) as an ROS production enhancer. The block copolymer consisting hydrophilic poly(ethylene glycol) (PEG) well segments thioketal-linked camptothecin (CPT) methacrylate (CPTKMA) 2-(pentamethyleneimino)ethyl (PEMA) (PEG-b-P(CPTKMA-co-PEMA)) self-assemble aqueous solution encapsulate VP with high loading efficiency 67%. Inside tissues, zeta potential transform from neutral positive for promoted cellular internalization under acidity. Followed by dose 4 Gy, efficient presence triggers CPT release. VP-loaded finally ablate tumors efficiently via synergistic radiochemotherapy deep penetration inside enhancement, triggered Consequently, this promising strategy represents robust modality enhanced cancers.

Язык: Английский

Процитировано

0