A simple acetylcholinesterase inhibition assay for the quantification of the nerve agent VX: Application in a Franz cell model with rat skin and various decontaminants

Toxicology Letters, Год журнала: 2025, Номер 404, С. 20 - 27

Опубликована: Янв. 14, 2025

Язык: Английский

Longer Acting Injectable: Continuous, Linear Release of a Progestin Contraceptive From an Oxidized Porous Silicon Host

Advanced Healthcare Materials, Год журнала: 2025, Номер unknown

Опубликована: Фев. 14, 2025

Abstract Maintaining stable drug concentrations in the bloodstream is a challenge for injectable hydrophobic progestin contraceptives. This work investigates porous silicon dioxide (pSiO 2 ) microparticles as delivery vehicle progestins via melt‐infiltration of drugs into mesopores. The pSiO prepared through electrochemical anodization single‐crystalline followed by thermal oxidation, yielding vertically oriented pores (≈50 nm diameter) with porosity varied (between 35–75%) to optimize loading and release. Among tested, etonogestrel levonorgestrel (LNG) decompose near their melting points, preventing melt infiltration. However, addition 20% cholesterol mass suppresses point LNG sufficiently enable without degradation. Mass loadings exceeding 50% (drug: + carrier) are achieved segesterone acetate (SEG) LNG, retaining crystallinity confirmed X‐ray diffraction. In vitro, both SEG LNG‐loaded display sustained release up 3 months, reduced burst release, more constant steady‐state concentrations, substantially tail compared pure or SEG, loaded from chloroform solution. pilot vivo study, SEG‐loaded well tolerated 20‐week‐old female rats over 25‐week period, no signs toxicity.

Язык: Английский

Amino-Functionalized Nano-UiO-66 for the Detection of Nerve Agent Analogs

ACS Applied Nano Materials, Год журнала: 2025, Номер unknown

Опубликована: Апрель 10, 2025

Язык: Английский