Small Methods, Год журнала: 2025, Номер unknown

Опубликована: Март 17, 2025

Abstract Traditional ophthalmic formulations are characterized by low bioavailability, short intraocular retention time, strong irritation, and failure to achieve the expected therapeutic effect due special physiological structure of eye existence many barriers. Microneedle drug delivery is a novel transdermal modality. Responsive microneedles defined as controllably releasing payloads in response stimuli, including pH levels, temperature, enzymes, reactive oxygen species (ROS), well external stimuli such magnetic fields light. In addition inheriting advantages traditional microneedles, which include enhanced targeting permeability, non‐invasiveness, painless application, integration with stimulus‐responsive materials enables responsive personalized precision process, further increases accuracy efficiency ocular treatments, making on‐demand possible. This article systematically reviews classification, mechanisms, characteristics provides detailed introduction their diagnostic applications real‐time monitoring potential diseases, aiming offer insights for treatment diseases future.

Язык: Английский