Optimally Aligned Nerve Scaffolds with Sustained Astaxanthin Release Enhance the Inflammatory Microenvironment Via Mitophagy Activation

Опубликована: Янв. 1, 2025

Язык: Английский

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Microwave-Orchestrated Phototherapeutic Polypyrrole/Soy Extraction Micro-complex for Burn Wound Healing in A Rodent Model

Journal of Drug Delivery Science and Technology, Год журнала: 2025, Номер unknown, С. 106911 - 106911

Опубликована: Апрель 1, 2025

Язык: Английский

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Ultrasound‐Responsive Piezoelectric Membrane Promotes Osteoporotic Bone Regeneration via the “Two‐Way Regulation” Bone Homeostasis Strategy

Advanced Science, Год журнала: 2025, Номер unknown

Опубликована: Апрель 28, 2025

Abstract The repair of osteoporotic bone defects remains inadequately addressed, primarily due to a disruption in homeostasis, characterized by insufficient formation and excessive resorption. Current research either focuses on promoting or inhibiting resorption, however, the efficacy these single‐target therapeutic strategies is limited. Herein, “two‐way regulation” homeostasis strategy proposed utilizing piezoelectric composite membranes (DAT/KS), capable simultaneously regulating osteogenesis osteoclastogenesis, with high performance, good biocompatibility, excellent degradability, promote regeneration under conditions. DAT/KS membrane ultrasound (US) treatment enables controlled modulation stimulation release saikosaponin D (SSD), which promotes osteogenic differentiation while osteoclast function, thereby effectively restoring enhancing repair. Mechanistic insights reveal promotion both canonical non‐canonical Wnt signaling marrow mesenchymal stem cells (BMSCs), determines their fate, downregulation NF‐κB mononuclear macrophages (BMMs). This study presents optimized sono‐piezoelectric biomaterials bidirectionally osteoclastic differentiation, providing new potential approach for pathological injuries.

Язык: Английский

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3D-Printable Photothermal and Temperature-Controlled Polycaprolactone Scaffolds Incorporating Gold Plasmonic Blackbodies for Bone Tissue Engineering

ACS Applied Materials & Interfaces, Год журнала: 2025, Номер unknown

Опубликована: Май 12, 2025

Three-dimensional (3D) printing technology has revolutionized the design and fabrication of bone scaffolds, offering precise customizable solutions for tissue engineering. In this study, we developed polycaprolactone (PCL) scaffolds that incorporated gold plasmonic blackbodies (AuPBs) to harness photothermal properties temperature-controlled regeneration. The AuPB-PCL demonstrated enhanced mechanical strength, a tunable thermal response under near-infrared (NIR) laser irradiation, improved osteogenic potential. Photothermal stimulation effectively modulated cellular responses, promoting osteoblast proliferation, alkaline phosphatase (ALP) activity, mineralization. Notably, mild hyperthermia (39-41 °C) induced by irradiation optimized osteogenesis, while excessive temperatures (≥42.5 impaired function due mitochondrial stress oxidative damage. These findings highlight potential controlled regeneration, promising strategy precise, completely noninvasive repair.

Язык: Английский

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Biophysical stimuli for promoting angiogenesis and vascularization in regenerative medicine and dentistry

Deleted Journal, Год журнала: 2025, Номер 2(3), С. 100078 - 100078

Опубликована: Май 17, 2025

Язык: Английский

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