Biomimetic Targeted Co‐Delivery System Engineered from Genomic Insights for Precision Treatment of Osteosarcoma
Advanced Science,
Год журнала:
2024,
Номер
12(2)
Опубликована: Ноя. 18, 2024
Abstract
The
high
heterogeneity
and
severe
side
effects
of
chemotherapy
are
major
factors
contributing
to
the
failure
osteosarcoma
treatment.
Herein,
a
comprehensive
genomic
analysis
is
conducted,
identified
two
prominent
characteristics
osteosarcoma:
significant
cyclin‐dependent
kinases
4
(CDK4)
amplification
homologous
recombination
repair
deficiency.
Based
on
these
findings,
co‐delivery
system
loaded
with
CDK4/6
inhibitors
poly
ADP‐ribose
polymerase
(PARP)
designed.
By
employing
metal–organic
frameworks
(MOFs)
as
carriers,
issue
drug
insolubility
effectively
addressed,
while
also
enabling
controlled
release
in
response
tumor
microenvironment.
To
enhance
targeting
capability
biocompatibility,
MOFs
further
coated
bio‐membrane
B7H3.
This
targeted
biomimetic
possesses
several
key
features:
1)
it
can
precisely
target
B7H3
expression;
2)
combination
PARP
exhibits
synergistic
effects,
significantly
impairing
tumor's
DNA
capacity;
3)
has
potential
for
photodynamic
therapy,
amplifying
defects
maximize
cell
eradication.
Furthermore,
observed
that
this
activate
immune
microenvironment,
increasing
CD8
+
T
infiltration
converting
from
an
immune‐cold
immune‐hot
tumor.
In
summary,
effective
therapeutic
strategy
holds
promise
novel
approach
Язык: Английский
Advancing Tumor Microenvironment Analysis: A Fluorescence Nanosystem for Caspase-1 Monitoring and Synergistic Therapy
Analytical Chemistry,
Год журнала:
2025,
Номер
unknown
Опубликована: Март 11, 2025
The
lack
of
precise,
real-time
analytical
tools
for
monitoring
tumor
microenvironment
changes
during
treatment
hinders
advancements
in
integrated
diagnostic
and
therapeutic
platforms.
Traditional
caspase-3
strategies
are
limited
by
their
inability
to
address
drug
resistance
newly
discovered
apoptotic
pathways,
leading
reduced
accuracy
practicality.
To
overcome
these
limitations,
we
developed
a
fluorescence-based
"Trojan
horse"
nanosystem,
PFpR@CM,
featuring
high-sensitivity
Caspase-1
detection,
tumor-targeted
delivery,
photothermal
therapy.
was
selected
as
biomarker
due
its
ability
provide
accurate
feedback
on
reactive
oxygen
species
(ROS)
generation.
system
employs
Fe-doped
polydopamine
nanoparticles
red
fluorescent
carbon
quantum
dots
(RCQDs)
the
core,
achieving
detection
limit
0.024
U/mL
with
linear
range
0.05-1.0
U/mL.
By
integrating
MG-63
cell
membrane
camouflage,
PFpR@CM
ensures
specificity
immune
evasion,
allowing
precise
situ
ROS
production
ferroptosis.
Experimental
results
demonstrate
that
enables
simultaneous
fluorescence
tracking
localized
interventions,
over
80%
volume
reduction
vivo
minimal
systemic
toxicity.
This
work
establishes
novel
chemistry
approach
multifunctional
treatment,
providing
an
innovative
solution
challenges
precision
oncology.
Язык: Английский
Light-Responsive Hydrogel with Nano-Microstructures for Bacteria Eradication and Tumor Therapy
ACS Applied Nano Materials,
Год журнала:
2025,
Номер
unknown
Опубликована: Март 17, 2025
Язык: Английский
Development of an innovative extracellular vesicle mimetic delivery platform for efficient miRNA delivery to tumours
Biomaterials,
Год журнала:
2025,
Номер
321, С. 123282 - 123282
Опубликована: Март 20, 2025
Язык: Английский
Innovative Sarcoma Therapy Using Multifaceted Nano-PROTAC-Induced EZH2 Degradation and Immunity Enhancement
Biomaterials,
Год журнала:
2025,
Номер
321, С. 123344 - 123344
Опубликована: Апрель 15, 2025
Язык: Английский
Crystal Violet-Loaded Bi(III)-Based Metal–Organic Framework Boosting Enhanced Photothermal Effect for Breast Cancer Treatment
ACS Applied Bio Materials,
Год журнала:
2025,
Номер
unknown
Опубликована: Апрель 15, 2025
Recently,
metal-organic
frameworks
(MOFs)
have
emerged
as
promising
platforms
to
fabricate
photothermal
therapeutic
materials
cure
tumors,
but
the
toxic
heavy
metals
in
many
MOFs
may
pose
great
threats
normal
cells.
In
consideration
of
low
toxicity
bismuth,
herein
we
made
efforts
synthesize
porous
bismuth-based
(Bi-MOFs)
construct
conversion
for
cancer
treatment.
By
reaction
4,4',4''-tricarboxylic
triphenylamine
(H3TCA)
and
Bi(NO3)3
under
solvothermal
conditions,
a
Bi-MOF
was
obtained
with
formula
{[Bi2(TCA)2(H2O)3]·6DMF·21H2O}n
(Bi-TCA).
Structural
analysis
revealed
that
complex
Bi-TCA
displayed
three-dimensional
(3D)
coordination
framework
featuring
abundant
accessible
channels
cages
porosity
73.3%
according
calculating
results
PLATON.
Due
high
porosity,
could
effectively
encapsulate
dye
crystal
violet
(CV)
into
voids
resulting
dye-loaded
composite
CV@Bi-TCA
exhibited
extended
red-shifted
light-absorbing
property
enhanced
capability
455
nm
laser
irradiation.
Further
anticancer
experiments
demonstrated
efficiently
inhibit
growth
breast
cells
both
vitro
vivo
This
work
promote
investigations
on
low-toxicity
Bi-MOFs
therapy.
Язык: Английский
Recent Advances in Cancer Cell Membrane‐Based Nanoparticles and Cancer Cell‐Derived Small Extracellular Vesicles as Drug Delivery Platforms
Advanced NanoBiomed Research,
Год журнала:
2025,
Номер
unknown
Опубликована: Апрель 19, 2025
Advances
in
nanotechnology
have
paved
the
way
for
innovative
drug
delivery
systems
that
enhance
effectiveness
of
cancer
treatment.
Cancer
cell
membrane‐based
nanoparticles
(CCM‐NPs)
and
cell‐derived
small
extracellular
vesicles
(CsEVs)
are
emerging
as
promising
treatment
due
to
their
inherent
properties
such
low
immunogenicity
natural
targeting
capabilities
cells.
However,
a
comprehensive
comparison
advantages,
disadvantages,
similarities
these
two
platforms
is
lacking.
This
review
summarizes
natural,
engineered,
hybrid
forms
CCM‐NPs
CsEVs‐based
with
focus
on
platforms,
considering
key
aspects
including
preparation
methods,
encapsulation
strategies,
pathways,
immune
evasion,
ability,
potential
clinical
applications.
By
understanding
strengths
weaknesses
each
approach,
aim
pave
next‐generation
nanoscale
contribute
development
more
effective
personalized
therapies.
Язык: Английский