YTHDFs as radiotherapy checkpoints in tumor immunity DOI
Chuangyu Wen, Emile Naccasha, Chuan He

и другие.

The Journal of Experimental Medicine, Год журнала: 2025, Номер 222(8)

Опубликована: Июнь 5, 2025

Radiotherapy (RT), a cornerstone of cancer treatment, exerts its therapeutic effects primarily by inducing DNA damage in tumor cells and modulating the immune microenvironment (TIME). Despite efficacy, RT is often counteracted tumor-intrinsic mechanisms, such as repair, well immune-suppressive responses. YTHDF proteins, key N6-methyladenosine (m6A) readers, have emerged pivotal regulators progression, cell function, making them promising targets for enhancing efficacy. In this review, we explore dual roles proteins both immune-mediated responses to RT. We summarize their influence on repair pathways impact TIME, which collectively shape antitumor efficacy Furthermore, discuss recent advances development YTHDF-targeting inhibitors potential synergize with immunotherapy, offering new avenues improve treatment outcomes.

Язык: Английский

YTHDFs as radiotherapy checkpoints in tumor immunity DOI
Chuangyu Wen, Emile Naccasha, Chuan He

и другие.

The Journal of Experimental Medicine, Год журнала: 2025, Номер 222(8)

Опубликована: Июнь 5, 2025

Radiotherapy (RT), a cornerstone of cancer treatment, exerts its therapeutic effects primarily by inducing DNA damage in tumor cells and modulating the immune microenvironment (TIME). Despite efficacy, RT is often counteracted tumor-intrinsic mechanisms, such as repair, well immune-suppressive responses. YTHDF proteins, key N6-methyladenosine (m6A) readers, have emerged pivotal regulators progression, cell function, making them promising targets for enhancing efficacy. In this review, we explore dual roles proteins both immune-mediated responses to RT. We summarize their influence on repair pathways impact TIME, which collectively shape antitumor efficacy Furthermore, discuss recent advances development YTHDF-targeting inhibitors potential synergize with immunotherapy, offering new avenues improve treatment outcomes.

Язык: Английский

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