Noninvasive electrical stimulation enhances the diabetic osseointegration via alleviating mitochondrial damage DOI Creative Commons

Dongzong Huang,

Rongchen Xu,

Changzhen Xu

и другие.

View, Год журнала: 2025, Номер unknown

Опубликована: Апрель 16, 2025

Abstract A high‐glucose environment induces an imbalance in mitochondrial homeostasis, and further results decreased autophagic capacity energy metabolism mitochondria. This dysfunction inhibits the regeneration of bone tissue. Electrical stimulation (ES) is efficient strategy to rebalance homeostasis accelerate process. However, traditional ES strategies are invasive easily cause secondary trauma, limiting their medical application. Here, we designed a new noninvasive direct‐current electric field (DCEF) strategy. can provide situ without implantation. The show that this target regulate through PI3K–AKT signaling pathway, activate autophagy, alleviate high‐glucose‐induced damage, promote osteogenic differentiation marrow mesenchymal stem cells. Consequently, exogenous effectively repair defects alleviating damage.

Язык: Английский

Noninvasive electrical stimulation enhances the diabetic osseointegration via alleviating mitochondrial damage DOI Creative Commons

Dongzong Huang,

Rongchen Xu,

Changzhen Xu

и другие.

View, Год журнала: 2025, Номер unknown

Опубликована: Апрель 16, 2025

Abstract A high‐glucose environment induces an imbalance in mitochondrial homeostasis, and further results decreased autophagic capacity energy metabolism mitochondria. This dysfunction inhibits the regeneration of bone tissue. Electrical stimulation (ES) is efficient strategy to rebalance homeostasis accelerate process. However, traditional ES strategies are invasive easily cause secondary trauma, limiting their medical application. Here, we designed a new noninvasive direct‐current electric field (DCEF) strategy. can provide situ without implantation. The show that this target regulate through PI3K–AKT signaling pathway, activate autophagy, alleviate high‐glucose‐induced damage, promote osteogenic differentiation marrow mesenchymal stem cells. Consequently, exogenous effectively repair defects alleviating damage.

Язык: Английский

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