Real-Time and Highly Sensitive Detection of Matrix Metalloproteinase 9 (MMP-9) in Tears Using Aptamer Functionalized Electrolyte-Gated IGZO Thin-Film Transistors DOI Creative Commons
Chuljin Hwang,

J. H. Lee,

D.H. Kim

и другие.

ACS Applied Materials & Interfaces, Год журнала: 2025, Номер unknown

Опубликована: Июнь 1, 2025

Dry eye disease (DED) is a common disorder characterized by unstable tear film homeostasis. Its symptoms range from foreign body sensations to pain and fluctuations in visual function. Current diagnostics include physical examination ocular surface imaging. Matrix metalloproteinase-9 (MMP-9) tears correlates with clinical signs of DED; however, because the limited sample volume, quantitative real-time detection MMP-9 significant need, complicated biochemical complexity tears. We developed an ultrasensitive, sensor based on electrolyte-gated indium-gallium-zinc oxide thin-film transistors (IGZO-EGTFTs), capable analyzing submicroliter volumes. The was functionalized at nanoscale improve binding capability aptamer, achieving limit 1 fg/mL. demonstrated excellent reproducibility over dynamic spanning 8 orders magnitude up 100 ng/mL (10-7 g/mL), which consistent DED patients. Additionally, sensing performance remained stable for 4 weeks, highlighting its potential future commercial applications. concentration human samples could be determined real time high sensitivity, provides promising diagnostic tools early detection, progression assessment, timely treatment DED.

Язык: Английский

Wearable Electrochemical Biosensors for Advanced Healthcare Monitoring DOI Creative Commons
Haowei Duan, Shuhua Peng, Shuai He

и другие.

Advanced Science, Год журнала: 2024, Номер 12(2)

Опубликована: Ноя. 26, 2024

Abstract Recent advancements in wearable electrochemical biosensors have opened new avenues for on‐body and continuous detection of biomarkers, enabling personalized, real‐time, preventive healthcare. While glucose monitoring has set a precedent biosensors, the field is rapidly expanding to include wider range analytes crucial disease diagnosis, treatment, management. In this review, recent key innovations are examined design manufacturing underpinning these biosensing platforms including biorecognition elements, signal transduction methods, electrode substrate materials, fabrication techniques. The applications then highlighted detecting variety biochemical markers, such as small molecules, hormones, drugs, macromolecules, biofluids interstitial fluid, sweat, wound exudate, saliva, tears. Additionally, review also covers advances platforms, multi‐sensory integration, closed‐loop control, power supply. Furthermore, challenges associated with critical issues discussed, biocompatibility, biofouling, sensor degradation, opportunities materials science, nanotechnology, artificial intelligence overcome limitations.

Язык: Английский

Процитировано

11

Recent advances and future prospects of wearable sensors based on nanomaterial sensing mechanisms for biosafety monitoring DOI

Xiaoyu Yu,

Hui Li, Junwen Wang

и другие.

Chemical Engineering Journal, Год журнала: 2025, Номер unknown, С. 162695 - 162695

Опубликована: Апрель 1, 2025

Язык: Английский

Процитировано

2

Electrochemical biosensors for enhanced detection of diabetes mellitus DOI
Yanyan Zhi, Shanshan Xie, Bowen Wei

и другие.

Clinica Chimica Acta, Год журнала: 2025, Номер unknown, С. 120221 - 120221

Опубликована: Фев. 1, 2025

Язык: Английский

Процитировано

0

Polymeric sensors for blood analysis: current and future scope of research DOI

Dipak Thikar,

Gaurav Gopal Naik,

Sarojini Verma

и другие.

Polymer International, Год журнала: 2025, Номер unknown

Опубликована: Апрель 28, 2025

Abstract This review explores the advancements in polymer‐based sensors for blood analysis, emphasizing online detection of key components such as uric acid, creatinine, urea, bilirubin, cholesterol, total proteins, amino acids and hormones. It categorizes polymer into electrochemical, optical molecularly imprinted polymers, providing insights their working mechanisms advantages biomarker identification. Recent innovations are highlighted to evaluate current state sensor technology terms selectivity, sensitivity real‐time monitoring capabilities. Challenges stability issues, biofouling compliance also addressed. The underscores transformative potential these diagnostics, role enhancing patient care through convenient point‐of‐care healthcare testing. © 2025 Society Chemical Industry.

Язык: Английский

Процитировано

0

Advancements in Wearable and Implantable BioMEMS Devices: Transforming Healthcare Through Technology DOI Creative Commons
Vishnuram Abhinav,

Prithvi Basu,

Saurabh Verma

и другие.

Micromachines, Год журнала: 2025, Номер 16(5), С. 522 - 522

Опубликована: Апрель 28, 2025

Wearable and implantable BioMEMSs (biomedical microelectromechanical systems) have transformed modern healthcare by enabling continuous, personalized, minimally invasive monitoring, diagnostics, therapy. advanced rapidly, encompassing a diverse range of biosensors, bioelectronic systems, drug delivery platforms, motion tracking technologies. These devices enable non-invasive, real-time monitoring biochemical, electrophysiological, biomechanical signals, offering personalized proactive solutions. In parallel, BioMEMS significantly enhanced long-term targeted delivery, neurostimulation. From continuous glucose intraocular pressure to programmable bioelectric implants for neuromodulation, these are improving precision treatment localized This review explores the materials technologies driving advancements in wearable BioMEMSs, focusing on their impact chronic disease management, cardiology, respiratory care, glaucoma treatment. We also highlight integration with artificial intelligence (AI) Internet Things (IoT), paving way smarter, data-driven Despite potential, face challenges such as regulatory complexities, global standardization, societal determinants. Looking ahead, we explore emerging directions like multifunctional biodegradable power sources, next-generation point-of-care diagnostics. Collectively, position pivotal enablers future patient-centric systems.

Язык: Английский

Процитировано

0

Electrochemical approaches for breast cancer biomarkers: A voltammetric study of electrode potential scanning DOI Creative Commons

Caiyu Liu,

Xiaokang Hu, Mohamed Mastouri

и другие.

Cell Reports Physical Science, Год журнала: 2025, Номер unknown, С. 102569 - 102569

Опубликована: Май 1, 2025

Язык: Английский

Процитировано

0

Transdermal Patches: Design, Evaluation, and Potential Applications in Modern Therapeutics DOI
P. V. Kulkarni,

Khaja Anees Ahmed,

Sidramappa B. Shirsand

и другие.

Deleted Journal, Год журнала: 2025, Номер unknown

Опубликована: Май 16, 2025

Язык: Английский

Процитировано

0

Innovations in wearable biosensors: A pathway to 24/7 personalized healthcare DOI

Ira Singh,

Santosh Kumar, Joonseok Koh

и другие.

Measurement, Год журнала: 2025, Номер unknown, С. 117938 - 117938

Опубликована: Май 1, 2025

Язык: Английский

Процитировано

0

Electrochemical nanosensors in therapeutic pharmaceutical monitoring: from drug followIng to clinical protocols DOI Creative Commons

Maritza Fernández,

Jahir Orozco

Electrochimica Acta, Год журнала: 2025, Номер unknown, С. 146550 - 146550

Опубликована: Май 1, 2025

Язык: Английский

Процитировано

0

Real-Time and Highly Sensitive Detection of Matrix Metalloproteinase 9 (MMP-9) in Tears Using Aptamer Functionalized Electrolyte-Gated IGZO Thin-Film Transistors DOI Creative Commons
Chuljin Hwang,

J. H. Lee,

D.H. Kim

и другие.

ACS Applied Materials & Interfaces, Год журнала: 2025, Номер unknown

Опубликована: Июнь 1, 2025

Dry eye disease (DED) is a common disorder characterized by unstable tear film homeostasis. Its symptoms range from foreign body sensations to pain and fluctuations in visual function. Current diagnostics include physical examination ocular surface imaging. Matrix metalloproteinase-9 (MMP-9) tears correlates with clinical signs of DED; however, because the limited sample volume, quantitative real-time detection MMP-9 significant need, complicated biochemical complexity tears. We developed an ultrasensitive, sensor based on electrolyte-gated indium-gallium-zinc oxide thin-film transistors (IGZO-EGTFTs), capable analyzing submicroliter volumes. The was functionalized at nanoscale improve binding capability aptamer, achieving limit 1 fg/mL. demonstrated excellent reproducibility over dynamic spanning 8 orders magnitude up 100 ng/mL (10-7 g/mL), which consistent DED patients. Additionally, sensing performance remained stable for 4 weeks, highlighting its potential future commercial applications. concentration human samples could be determined real time high sensitivity, provides promising diagnostic tools early detection, progression assessment, timely treatment DED.

Язык: Английский

Процитировано

0