A Gelatin‐Based Bioadhesive Featuring Mechanically Induced Glue‐To‐Gel Transition DOI Open Access
Wencheng Liang, Kun Lei,

Jiakang Zhang

и другие.

Advanced Functional Materials, Год журнала: 2025, Номер unknown

Опубликована: Март 18, 2025

Abstract In the field of bioadhesives, development machinable adhesives with a “glue‐to‐gel transition” remains significant challenge. This study presents novel design strategy to endow Gel/Eg adhesive mechanical machinability. It leverages combination hydrogen bond interactions, metal complexation, and secondary structure gelatin through one‐step mixing method. Rheological analysis shows that exhibits frequency‐dependent transition,” maintaining glue state at low frequencies transitioning gel higher frequencies. During stretching, β‐sheet transforms into random coil structure. Moreover, features excellent water resistance, swelling ratio, strong adhesion strength, high extensibility, instantaneous adhesion, self‐healing, both biocompatibility hemocompatibility. These attributes enable exhibit multiple fault‐tolerance capabilities on tissue surfaces, highlighting its potential for diverse biomedical applications.

Язык: Английский

Tuning Room-Temperature Injectability of Gelatin-Based Hydrogels via Introduction of Competitive Hydrogen Bonds DOI
Dong‐Lin Xie, Jiang Bian, Chao Ni

и другие.

ACS Macro Letters, Год журнала: 2025, Номер unknown, С. 313 - 319

Опубликована: Фев. 24, 2025

As a natural biomaterial with superior comprehensive performance, gelatin has been widely explored in various biomedical and bioengineering applications. However, the ease of solidification solutions at room temperature causes great inconvenience specific application scenarios where injection is required. Here we addressed this problem by introduction competitive hydrogen bond (CHB)-containing substances to interfere original intergelatin bonds. Four representative CHB materials, metformin, l-arginine, polyarginine, polyurea, all showed remarkable efficiency tuning "sol-gel" phase transition concentration-dependent manner. Systematic rheological measurements indicated that addition materials significantly improved room-temperature injectability gelatin. Compared alone, CHB-containing bioinks printability shape fidelity 3D bioprinting.

Язык: Английский

Процитировано

0
A Gelatin‐Based Bioadhesive Featuring Mechanically Induced Glue‐To‐Gel Transition DOI Open Access
Wencheng Liang, Kun Lei,

Jiakang Zhang

и другие.

Advanced Functional Materials, Год журнала: 2025, Номер unknown

Опубликована: Март 18, 2025

Abstract In the field of bioadhesives, development machinable adhesives with a “glue‐to‐gel transition” remains significant challenge. This study presents novel design strategy to endow Gel/Eg adhesive mechanical machinability. It leverages combination hydrogen bond interactions, metal complexation, and secondary structure gelatin through one‐step mixing method. Rheological analysis shows that exhibits frequency‐dependent transition,” maintaining glue state at low frequencies transitioning gel higher frequencies. During stretching, β‐sheet transforms into random coil structure. Moreover, features excellent water resistance, swelling ratio, strong adhesion strength, high extensibility, instantaneous adhesion, self‐healing, both biocompatibility hemocompatibility. These attributes enable exhibit multiple fault‐tolerance capabilities on tissue surfaces, highlighting its potential for diverse biomedical applications.

Язык: Английский

Процитировано

0