Recent advances in biomimetic nanodelivery systems for the treatment of glioblastoma
Colloids and Surfaces B Biointerfaces,
Год журнала:
2025,
Номер
unknown, С. 114668 - 114668
Опубликована: Март 1, 2025
Язык: Английский
Using Regular Porous Membrane-Based Blood–Brain Barrier Model to Screen Brain-Targeted Drugs with Nanochannel Electrochemistry
Analytical Chemistry,
Год журнала:
2025,
Номер
unknown
Опубликована: Апрель 4, 2025
Constructing
in
vitro
blood-brain
barrier
(BBB)
model
provides
an
innovative
approach
for
studying
the
pathophysiology
of
brain
and
screening
drugs.
Although
commercial
Transwell
was
simplest
most
widely
utilized
model,
reasonably
mimicking
essential
characteristics
human
BBB
dynamic
monitoring
function
remain
a
challenge.
Herein,
inspired
by
highly
permeable
extracellular
matrix
membrane
BBB,
novel
established
combining
functionalized
anodic
alumina
oxide
(AAO)
with
nanochannel
electrochemistry
(ANE-BBB).
Benefiting
from
topographical
nanostructures
modified
cell-adhesive
peptide
on
AAO
surface,
tight
endothelial
formed,
which
can
be
directly
visualized
phase-contrast
microscope,
real
time
monitored
electrochemistry.
More
importantly,
according
to
current
signal
induced
diffusion
redox
species
through
nanochannels
toward
underlying
electrode
evaluation
BBB-crossing
behavior
precise
brain-targeted
nanodrugs
achieved.
The
constructed
ANE-BBB
overcomes
shortcomings
invisible
cell
culture,
low
permeability,
inaccurate
real-time
drugs
traditional
reliable
tool
design
central
nervous
system.
Язык: Английский
Nanozymes in biomedicine: Unraveling trends, research foci, and future trajectories via bibliometric insights (from 2007 to 2024)
International Journal of Biological Macromolecules,
Год журнала:
2025,
Номер
unknown, С. 142798 - 142798
Опубликована: Апрель 1, 2025
Язык: Английский
Recent Advances in Biomimetic Nanodelivery Systems for the Treatment of Depression
Materials Today Bio,
Год журнала:
2025,
Номер
32, С. 101781 - 101781
Опубликована: Апрель 17, 2025
Depression
and
cognitive
disorders
remain
major
challenges
in
healthcare,
with
conventional
treatments
often
facing
limitations
such
as
slow
onset,
side
effects,
poor
drug
delivery
to
the
brain.
Biomimetic
nanodelivery
systems,
including
nanozymes,
cell
membrane-based
exosomes,
have
emerged
promising
solutions
these
issues.
These
systems
leverage
natural
biological
processes
enhance
targeting,
improve
bioavailability,
regulate
complex
pathways.
Nanoenzymes,
their
catalytic
properties,
offer
antioxidant
anti-inflammatory
benefits,
while
membranes
exosomes
provide
efficient
targeting
immune
evasion.
However,
remain,
immaturity
of
large-scale
production
techniques,
stability
concerns,
incomplete
understanding
mechanisms
action.
Moreover,
long-term
safety,
pharmacokinetics,
toxicity
require
further
investigation.
Despite
obstacles,
potential
biomimetic
revolutionize
depression
treatment
is
significant.
Future
research
should
focus
on
optimizing
preparation,
improving
release,
ensuring
clinical
safety.
Multidisciplinary
collaboration
will
be
essential
for
advancing
from
laboratory
practice,
offering
new
therapeutic
avenues
other
neurological
disorders.
Язык: Английский
ARHGDIB as a prognostic biomarker and modulator of the immunosuppressive microenvironment in glioma
Cancer Immunology Immunotherapy,
Год журнала:
2025,
Номер
74(7)
Опубликована: Май 15, 2025
Glioma,
a
prevalent
malignant
intracranial
tumor,
exhibits
limited
therapeutic
efficacy
due
to
its
immunosuppressive
microenvironment,
leading
poor
prognosis
for
patients.
ARHGDIB
is
implicated
in
the
remodeling
of
tumor
microenvironment
and
plays
significant
role
pathogenesis
various
tumors.
However,
regulatory
effect
within
immune
glioma
remains
unclear.
The
mRNA
expression
pattern
was
analyzed
using
public
databases,
further
validated
our
collected
cohort
through
quantitative
PCR
(qPCR)
immunohistochemistry
(IHC).
Kaplan-Meier
survival
analysis
LASSO-Cox
regression
were
employed
ascertain
clinical
significance
glioma.
Subsequently,
we
systematically
evaluated
association
between
characteristics
as
well
potential
predict
treatment
response
Additionally,
vitro
experiments
conducted
elucidate
promoting
malignancy
progression.
Combined
with
bioinformatics
databases
validation
qPCR
IHC
on
cohort,
findings
indicate
that
markedly
overexpressed
correlates
patient
prognosis,
thereby
serving
biomarker
adverse
outcomes
Functional
enrichment
infiltration
analyses
reveal
recruitment
cells,
such
M2
macrophages
neutrophils,
contributing
alteration
hindering
response.
Further
investigations
single-cell
sequencing,
immunohistochemistry,
immunofluorescence,
demonstrate
an
akin
CD163,
overexpression
inducing
macrophage
polarization
facilitating
cell
proliferation
migration.
emerges
novel
marker
tumor-associated
macrophages,
playing
crucial
shaping
representing
promising
prognostic
Язык: Английский