Deciphering the multifaceted role of circular RNA in aging: from molecular mechanisms to therapeutic potentials DOI Creative Commons

Yang Wang,

Cong Wang, Xin Dai

и другие.

Non-coding RNA Research, Год журнала: 2025, Номер unknown

Опубликована: Май 1, 2025

Язык: Английский

Circular RNAs modulate cell death in cardiovascular diseases DOI Creative Commons
Rongfang Pan,

Christine X. Koo,

Wenyuan Su

и другие.

Cell Death Discovery, Год журнала: 2025, Номер 11(1)

Опубликована: Май 2, 2025

Язык: Английский

Процитировано

0
Sestrin2 alleviates cognitive impairment via inhibiting hippocampus ferroptosis in cigarette smoke-induced chronic obstructive pulmonary disease DOI Creative Commons
Dawei Zhang, Mingming Yang,

Meng-Xi Zhou

и другие.

Redox Biology, Год журнала: 2025, Номер unknown, С. 103673 - 103673

Опубликована: Май 1, 2025

Cognitive dysfunction is an essential comorbidity that contributing to the whole disease process of individual chronic obstructive pulmonary (COPD), yet its specific mechanism remains controversial due a lack cellular and molecular evidence. Our clinical data revealed significant reduction in total hippocampal volume patients with COPD, CA1 subfield notably smaller associated lung function. Long-term CS exposure caused hippocampus impairment, leading spatial working memory impairments COPD model mice. triggered ferroptosis vivo vitro. Bioinformatics analysis suggested sestrin2 key ferroptosis-related gene involved cognitive impairment. Sestrin2 protein levels were consistently increased mice CSE treated HT22 cells. knockdown exacerbated enhanced down-regulation synaptophysin PSD95, while overexpression inhibited these damaging processes This neuroprotection dependent on binding heterogeneous nuclear ribonucleoprotein L (HNRNPL). Moreover, DFO ameliorated impairment neurocognitive deficits by correcting CS-induced synaptic proteins alterations vivo. Overall, our study reveals improves adverse changes neurons neurobehavior, providing new insights into mechanisms underlying COPD-related dysfunction.

Язык: Английский

Процитировано

0
The roles and mechanisms of non-canonical RNA secondary structures in tumors DOI
Ziyi Pan, Zhaoyang Zeng, Wei Xiong

и другие.

Biochimica et Biophysica Acta (BBA) - Reviews on Cancer, Год журнала: 2025, Номер 1880(4), С. 189363 - 189363

Опубликована: Май 31, 2025

Язык: Английский

Процитировано

0
Deciphering the multifaceted role of circular RNA in aging: from molecular mechanisms to therapeutic potentials DOI Creative Commons

Yang Wang,

Cong Wang, Xin Dai

и другие.

Non-coding RNA Research, Год журнала: 2025, Номер unknown

Опубликована: Май 1, 2025

Язык: Английский

Процитировано

0