Oxidative Stress and Redox Signaling in Gastric Cancer: From Mechanisms to Therapeutic Implications DOI Creative Commons
Zehua Chen,

Jiawu Fan,

Xiao‐Long Chen

и другие.

Antioxidants, Год журнала: 2025, Номер 14(3), С. 258 - 258

Опубликована: Фев. 24, 2025

Oxidative stress, which is characterized by an imbalance between reactive oxygen species (ROS) production and antioxidant defenses, has critical roles in the initiation, progression, treatment of gastric cancer. On one hand, excessive ROS accumulation induces oxidative damage cancer cell death. other moderate levels cause genetic mutations dysregulation signaling pathways to promote proliferation, inflammation, angiogenesis, metastasis Notably, emerging evidence revealed that also mediate post-translational modifications (oxPTMs) redox-sensitive proteins, can directly affect protein functions regulate redox cells. Therefore, elucidating regulatory mechanisms stress holds great promise identify novel therapeutic targets or redox-targeting strategies. This review will summarize regulating hallmarks highlight ROS-mediated oxPTMs In addition, we discuss strategies targeting for cancer, with emphasis on use bioactive natural products nanomaterials.

Язык: Английский

Oxidative Stress and Redox Signaling in Gastric Cancer: From Mechanisms to Therapeutic Implications DOI Creative Commons
Zehua Chen,

Jiawu Fan,

Xiao‐Long Chen

и другие.

Antioxidants, Год журнала: 2025, Номер 14(3), С. 258 - 258

Опубликована: Фев. 24, 2025

Oxidative stress, which is characterized by an imbalance between reactive oxygen species (ROS) production and antioxidant defenses, has critical roles in the initiation, progression, treatment of gastric cancer. On one hand, excessive ROS accumulation induces oxidative damage cancer cell death. other moderate levels cause genetic mutations dysregulation signaling pathways to promote proliferation, inflammation, angiogenesis, metastasis Notably, emerging evidence revealed that also mediate post-translational modifications (oxPTMs) redox-sensitive proteins, can directly affect protein functions regulate redox cells. Therefore, elucidating regulatory mechanisms stress holds great promise identify novel therapeutic targets or redox-targeting strategies. This review will summarize regulating hallmarks highlight ROS-mediated oxPTMs In addition, we discuss strategies targeting for cancer, with emphasis on use bioactive natural products nanomaterials.

Язык: Английский

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