Recent strategies for enhanced delivery of mRNA to the lungs DOI
Brittany J. Heiser, Arian Veyssi, Debadyuti Ghosh

и другие.

Nanomedicine, Год журнала: 2025, Номер unknown, С. 1 - 27

Опубликована: Апрель 7, 2025

mRNA-based therapies have emerged as a transformative tool in modern medicine, gaining significant attention following their successful use COVID-19 vaccines. Delivery to the lungs offers several compelling advantages for mRNA delivery. The are one of most vascularized organs body, which provides an extensive surface area that can facilitate efficient drug transport. Local delivery bypasses gastrointestinal degradation, potentially enhancing therapeutic efficacy. In addition, capillary network ideal target systemic However, developing effective presents challenges. complex anatomy and body's immune response foreign particles create barriers This review discusses key approaches overcoming these challenges improving lungs. It examines both local strategies aimed at lung while mitigating off-target effects. Although substantial progress has been made lung-targeted therapies, remain optimizing cellular uptake achieving efficacy within pulmonary tissues. continued refinement enhance lung-specific targeting minimizing degradation is critical clinical success therapies.

Язык: Английский

Recent strategies for enhanced delivery of mRNA to the lungs DOI
Brittany J. Heiser, Arian Veyssi, Debadyuti Ghosh

и другие.

Nanomedicine, Год журнала: 2025, Номер unknown, С. 1 - 27

Опубликована: Апрель 7, 2025

mRNA-based therapies have emerged as a transformative tool in modern medicine, gaining significant attention following their successful use COVID-19 vaccines. Delivery to the lungs offers several compelling advantages for mRNA delivery. The are one of most vascularized organs body, which provides an extensive surface area that can facilitate efficient drug transport. Local delivery bypasses gastrointestinal degradation, potentially enhancing therapeutic efficacy. In addition, capillary network ideal target systemic However, developing effective presents challenges. complex anatomy and body's immune response foreign particles create barriers This review discusses key approaches overcoming these challenges improving lungs. It examines both local strategies aimed at lung while mitigating off-target effects. Although substantial progress has been made lung-targeted therapies, remain optimizing cellular uptake achieving efficacy within pulmonary tissues. continued refinement enhance lung-specific targeting minimizing degradation is critical clinical success therapies.

Язык: Английский

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