
Research Square (Research Square), Год журнала: 2024, Номер unknown
Опубликована: Ноя. 5, 2024
Язык: Английский
Research Square (Research Square), Год журнала: 2024, Номер unknown
Опубликована: Ноя. 5, 2024
Язык: Английский
Cyborg and Bionic Systems, Год журнала: 2025, Номер 6
Опубликована: Янв. 1, 2025
Materials that establish functional, stable interfaces to targeted tissues for long-term monitoring/stimulation equipped with diagnostic/therapeutic capabilities represent breakthroughs in biomedical research and clinical medicine. A fundamental challenge is the mechanical chemical mismatch between implants ultimately results device failure corrosion by biofluids associated foreign body response. Of particular interest development of bioactive materials at level chemistry mechanics high-performance, minimally invasive function, simultaneously tissue-like compliance vivo biocompatibility. This review summarizes most recent progress these purposes, an emphasis on material properties such as response, integration schemes biological tissues, their use bioelectronic platforms. The article begins overview emerging classes platforms bio-integration proven utility live animal models, high performance different form factors. Subsequent sections various flexible, soft materials, ranging from self-healing hydrogel/elastomer bio-adhesive composites materials. Additional discussions highlight examples active systems support electrophysiological mapping, stimulation, drug delivery treatments related diseases, spatiotemporal resolutions span cellular organ-scale dimension. Envisioned applications involve advanced brain, cardiac, other organ systems, offer stability human subjects models. Results will inspire continuing advancements functions benign thus yielding therapy diagnostics healthcare.
Язык: Английский
Процитировано
3ACS Nano, Год журнала: 2025, Номер unknown
Опубликована: Фев. 23, 2025
Achieving high-quality biopotential signal recordings requires soft and stable interfaces between tissues bioelectronic devices. Traditional bioelectronics, typically rigid dependent on medical tape or sutures, lead to mechanical mismatches inflammatory responses. Existing conducting polymer-based bioelectronics offer tissue-like softness but lack intrinsic adhesion, limiting their effectiveness in creating stable, conductive interfaces. Here, we present an intrinsically adhesive hydrogel with a modulus strong adhesion various substrates. Adhesive catechol groups are incorporated into the poly(3,4-ethylenedioxythiophene) (PEDOT) matrix, which reduces PEDOT size improves dispersity form percolating network excellent electrical conductivity strain insensitivity. This effectively bridges bioelectronics–tissue interface, ensuring pristine minimal interference from bodily movements. capability is demonstrated through comprehensive vivo experiments, including electromyography electrocardiography both static dynamic human skin electrocorticography moving rats. represents significant advancement for interfaces, facilitating more accurate less intrusive diagnostics.
Язык: Английский
Процитировано
3Biosensors and Bioelectronics, Год журнала: 2024, Номер 258, С. 116328 - 116328
Опубликована: Апрель 25, 2024
Язык: Английский
Процитировано
10Advanced Materials, Год журнала: 2025, Номер unknown
Опубликована: Апрель 1, 2025
Intelligent wearable sensors, empowered by machine learning and innovative smart materials, enable rapid, accurate disease diagnosis, personalized therapy, continuous health monitoring without disrupting daily life. This integration facilitates a shift from traditional, hospital-centered healthcare to more decentralized, patient-centric model, where sensors can collect real-time physiological data, provide deep analysis of these data streams, generate actionable insights for point-of-care precise diagnostics therapy. Despite rapid advancements in learning, sensing technologies, there is lack comprehensive reviews that systematically examine the intersection fields. review addresses this gap, providing critical technologies advanced materials artificial Intelligence. The state-of-the-art materials-including self-healing, metamaterials, responsive materials-that enhance sensor functionality are first examined. Advanced methodologies integrated into devices discussed, their role biomedical applications highlighted. combined impact intelligent therapeutics also Finally, existing challenges, including technical compliance issues, information security concerns, regulatory considerations addressed, future directions advancing proposed.
Язык: Английский
Процитировано
2npj Flexible Electronics, Год журнала: 2024, Номер 8(1)
Опубликована: Авг. 29, 2024
Twenty-four hours continuous intraocular pressure (IOP) monitoring is beneficial for glaucoma care. Contact lens sensors using LC technology can achieve non-invasive IOP measuring around the clock and are relatively simple in principle structure, thus dominating mainstream. Among them, stretchable inductive contact constructed with liquid metal have advantages signal quality as well wearing comfort, but currently its sensitivity slightly insufficient. Here, we propose an sensor that to form inductance capacitance further. The capacitive plate coil response changes simultaneously, able enhance principle. We modeled sensing mechanism conducted design, fabrication, various tests. device exhibits good characteristics, including reliability, quality, etc. Especially, it has a threefold increase sensitivity, exceeding current state-of-the-art sensors.
Язык: Английский
Процитировано
5Cell Reports Physical Science, Год журнала: 2024, Номер 5(9), С. 102149 - 102149
Опубликована: Авг. 13, 2024
Язык: Английский
Процитировано
3Advanced Materials, Год журнала: 2025, Номер unknown
Опубликована: Апрель 15, 2025
Bioelectronic medicine uses implantable electronic devices to interface with electrically active tissues and transform the way disease is diagnosed treated. One of biggest challenges development minimally invasive that can be deployed patients at scale. Responsive materials soft robotic actuators offer unique opportunities make bioelectronic shape actuation, promising address limitations existing rigid passive systems, including difficult deployment, mechanical mismatch tissues, limited adaptability in settings. In this review, an overview provided smart technologies show promises for use, discussing advantages underlying actuation mechanisms. Examples are then presented where actuating mechanisms combined microelectrodes create devices. Opportunities next-generation intelligent assisted by responsive discussed. These innovations may allow implants safely navigate target areas inside body establish large area spatiotemporally controlled interfaces diagnostic or therapeutic procedures invasive.
Язык: Английский
Процитировано
0ACS Nano, Год журнала: 2025, Номер unknown
Опубликована: Апрель 18, 2025
Owing to their excellent conformability and functional advantages derived from spatially induced structures, 3D conformal curvy electronics have garnered attention for emerging applications in biomedical healthcare, soft machines, imagers, etc. In this perspective, the historical evolution of is summarized, with representative examples highlighted developmental trends outlined. The design strategies are discussed across materials, interfaces, assessment. Subsequently, diverse fabrication technologies reviewed, including direct fabrication, transfer printing, shape reconfiguration. Afterward, typical presented, classified by integration biological tissues, function-engineered surfaces. Finally, existing challenges potential research directions provided further exploration.
Язык: Английский
Процитировано
0Materials Today Communications, Год журнала: 2025, Номер unknown, С. 112658 - 112658
Опубликована: Апрель 1, 2025
Язык: Английский
Процитировано
0Science Advances, Год журнала: 2025, Номер 11(22)
Опубликована: Май 30, 2025
Variable stiffness electronics represent the forefront of adaptive technology, integrating rigid and soft in a single system through dynamic mechanical modulation. While gallium’s high modulus tuning ratio rapid phase transitions make it ideal for transformative electronic systems (TES), its liquid-state instability, surface tension, unintended during processing pose substantial challenges. Here, we introduce STiffness-Adjustable temperature-Responsive ink (STAR ink), chemically sinterable gallium composite designed to overcome these obstacles. STAR enables high-resolution (~50 micrometers) circuit patterning, large-scale batch fabrication, three-dimensional structure coating at room temperature. Through pH-controlled chemical sintering, ink–based TES exhibits exceptional tunability (tuning ratio: 1465) electrical conductivity (2.27 × 10 6 siemens per meter). Demonstrated applications—from multilayered variable printed boards (PCBs) matching standard PCBs’ complexity body-temperature responsive neural probe—underscore ink’s potential reconfigurable across consumer biomedical devices.
Язык: Английский
Процитировано
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