Frailty as a Predictor of COVID-19 Mortality in the South Indian Population: An Observational Study DOI Open Access

Niveda Srivatsa,

Nirmala Chandrasekaran,

Mohammed Suhail Tazeem

и другие.

Cureus, Год журнала: 2024, Номер unknown

Опубликована: Окт. 4, 2024

Background Frailty is a clinical syndrome characterized by diminished strength, endurance, and physiological function that significantly increases vulnerability to adverse health outcomes, including infections. In the context of COVID-19, frailty has emerged as critical risk factor for severe disease, complications, mortality, particularly in older adults. The severity fatality rates among geriatric group were notably high, virus's pathogenesis, marked prolonged inflammation, contributed increased morbidity mortality this age group. study was conducted explore role influencing elderly affected COVID-19. Objective objective identify association between COVID-19-affected patients. Methods We prospective observational patients who tested positive COVID-19 received treatment tertiary care hospital. Data collected from 250 March 2021 December 2021. Lab parameters, necessity mechanical ventilation, need oxygen use, number days hospital stay recorded. Clinical Score (CFS) used evaluate frailty. chi-square test with Fisher's exact assess data set. Multivariate binary logistic regression employed most significant predictors mortality. Results Among patients, 159 (63.6%) survived discharged, while 91 (36.4%) succumbed illness. Fifty-eight not identified frail, there no deaths On contrary, 192 COVID-positive (47.4%) died, 101 (52.6%) alive. This depicted While assessing comorbidities, malignancy (53.3%, p-value = 0.009) chronic kidney disease (CKD) (43.3%) had Symptoms like fever (43.6%), dyspnea (68.6%), myalgia (20%), altered sensorium (84%) showed strong correlation (p<0.001). predictor 47.4% frail surviving Biochemical markers leukocytosis (64.8%), neutrophilia (65.3%), eosinopenia (66.9%), anemia (57.8%), hypoalbuminemia (63.5%), hypoproteinemia (70.1%), elevated alanine aminotransferase (ALT) (66%), aspartate (AST) (65.2%), alkaline phosphatase (ALP) (67.5%), creatinine (68.9%), hypernatremia (100%), hyperkalemia (80%), D-dimer (44.7%) all linked Additionally, requiring (65%), ventilation (96.8%), or bilevel airway pressure (BiPAP) (77.8%) higher rates. A shorter length also associated (24%). Conclusion Frailty, combined certain comorbidities such cancer CKD, along various biochemical markers, played predicting Incorporating assessments into routine evaluations survivors could be beneficial. Early detection focused management these high-risk factors are essential improving outcomes within settings.

Язык: Английский

La geriatría dentro del sistema sanitario español: pasado y futuro DOI
José Manuel Ribera Casado, Alfonso J. Cruz‐Jentoft

Revista Española de Geriatría y Gerontología, Год журнала: 2025, Номер 60(2), С. 101626 - 101626

Опубликована: Янв. 31, 2025

Язык: Английский

Процитировано

0
Sarcopenia and COVID-19 - a complex pathological duet DOI Creative Commons
С. В. Булгакова, D. P. Kurmaev, E. V. Treneva

и другие.

Experimental and Clinical Gastroenterology, Год журнала: 2025, Номер 8, С. 196 - 215

Опубликована: Фев. 3, 2025

March 11, 2020 The World Health Organization has declared the New Coronavirus Infection 2019 (COVID-19) a pandemic. risk of complications in acute period COVID-19 was obvious almost immediately. However, back 2020, during onset and height pandemic, health professionals began to think about possible negative long-term delayed consequences COVID-19. Until now, world is facing among survivors, who often have multisystem pathological manifestations. study continues be an urgent problem modern medical science. Currently, increased attention being paid sarcopenia, which occurred patients after On other hand, sarcopenia predictor adverse outcomes with new coronavirus infection. In self-isolation regime (lockdown) introduced many countries as effective anti-epidemic strategy. Unfortunately, led decrease physical activity, especially elderly senile people. Therefore, inactivity against background itself factor for sarcopenia. addition, self-isolation, experienced increase caloric content their diet development obesity. Rehabilitation necessarily includes measures prevention treatment Thus, this literature review devoted relationship between

Язык: Английский

Процитировано

0
Fall-related mortality in older persons during the COVID-19 pandemic DOI
Camilla Mattiuzzi, Fabián Sanchís-Gomar, Giuseppe Lippi

и другие.

Journal of Gerontology and Geriatrics, Год журнала: 2025, Номер 73(1), С. 29 - 31

Опубликована: Март 1, 2025

Язык: Английский

Процитировано

0
Frailty after COVID‐19: The wave after? DOI Creative Commons
Maximilian König, Maik Gollasch,

Yulia Komleva

и другие.

Aging Medicine, Год журнала: 2023, Номер 6(3), С. 307 - 316

Опубликована: Июнь 28, 2023

The COVID-19 pandemic poses an ongoing public health challenge, with a focus on older adults. Given the large number of persons who have recovered from and reports long-lasting sequelae, there is reasonable concern that may lead to long-term deterioration in adults, i.e., potential "wave frailty." Therefore, it critical better understand circumstances surrounding development frailty as result COVID-19, well underlying mechanisms factors contributing this development. We conducted narrative review most relevant articles published association between through January 2023. Although few studies date addressed effects onset progression frailty, available data suggest indeed increase elderly COVID-19. Regarding mechanisms, multicausal genesis can be assumed, involving both direct viral indirect effects, particularly imposed lockdowns devastating consequences for elderly: decreased physical activity, altered diet, sarcopenia, fatigue, social isolation, neurological problems, inflammation, cardiovascular morbidity are among possible mediators. Since leading elderly, urgent need raise awareness still little-known problem potentially great importance find appropriate prevention treatment measures.

Язык: Английский

Процитировано

10
Secondary infections and long-term outcomes among hospitalized elderly and non-elderly patients with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and treated with baricitinib: a comparative study from the national centre of Hungary DOI Creative Commons
Zsófia Gáspár, Bálint Gergely Szabó, Hajnalka Andrikovics

и другие.

GeroScience, Год журнала: 2024, Номер 46(3), С. 2863 - 2877

Опубликована: Фев. 17, 2024

Abstract Baricitinib is considered a first-line treatment for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)-infected adult patients with an associated cytokine storm (CSS). Our objective was to compare rates of secondary infections and long-term outcomes elderly non-elderly who received baricitinib COVID-19. We conducted single-centre observational study between November 2020 September 2023, focusing on hospitalized SARS-CoV-2 CSS, categorized as (≥ 65 years) (< years). Enrolment, severity stratification, diagnosis infectious complications followed predefined criteria. Outcomes all-cause mortality non-severe were assessed at 1-year post-treatment initiation. Kaplan–Meier analysis performed survival analysis. In total, 490 enrolled (median age ± 23 (21–100) years (years, median IQR, min–max); 49.18% elderly; 59.59% male). Elderly admitted the hospital significantly earlier (7 5 days vs. 8 4 days; p = 0.02), experienced higher occurrence COVID-19 (121/241, 50.21% 98/249, 39.36%; required use non-invasive ventilation baseline (167/225, 74.22% 153/236, 64.83%; 0.03). At 1 year, in subgroup (111/241, 46.06% 29/249, 11.65%; < 0.01). 90 any infection also more prevalent among (56/241, 23.24% 37/249 14.86%; 0.02 58/241, 24.07% 39/249, 15.66%; 0.02). conclusion, SARS-CoV-2-infected experience clinical course, rates, increased risk mortality, regardless immunomodulatory therapy.

Язык: Английский

Процитировано

3
Management of patients with neurological diseases considering post‐pandemic coronavirus disease 2019 (COVID‐19) related risks and dangers — An updated European Academy of Neurology consensus statement DOI Creative Commons
Saša R. Filipović, Şerefnur Öztürk, Dániel Bereczki

и другие.

European Journal of Neurology, Год журнала: 2024, Номер 31(10)

Опубликована: Авг. 1, 2024

In October 2020, the European Academy of Neurology (EAN) consensus statement for management patients with neurological diseases during coronavirus disease 2019 (COVID-19) pandemic was published. Due to important changes and developments that have happened since then, need has arisen critically reassess original recommendations address new challenges.

Язык: Английский

Процитировано

2
Changes in frailty and lifestyle among community-dwelling older adults: A two-point cross-sectional study during and after the COVID-19 pandemic in Japan DOI
Tomoyuki Shinohara,

Kosuke Saida,

Shigeya Tanaka

и другие.

Geriatric Nursing, Год журнала: 2024, Номер 58, С. 208 - 214

Опубликована: Июнь 3, 2024

Язык: Английский

Процитировано

1
Burden of Acute Respiratory Infections Caused by Influenza Virus, Respiratory Syncytial Virus, and SARS-CoV-2 with Consideration of Older Adults: A Narrative Review DOI Creative Commons
William P. Hanage,

William Schaffner

Infectious Diseases and Therapy, Год журнала: 2024, Номер unknown

Опубликована: Дек. 30, 2024

Influenza virus, respiratory syncytial virus (RSV), and severe acute syndrome coronavirus 2 (SARS-CoV-2) are infections (ARIs) that can cause substantial morbidity mortality among at-risk individuals, including older adults. In this narrative review, we summarize themes identified in the literature regarding epidemiology, seasonality, immunity after infection, clinical presentation, transmission for these ARIs, along with impact of COVID-19 pandemic on seasonal patterns influenza RSV infections, consideration data specific to adults when available. As adult population increases globally, it is paramount importance fully characterize true disease burden ARIs order develop appropriate mitigation strategies minimize their vulnerable populations. Challenges associated characterizing diseases include shared symptomology presentation RSV, SARS-CoV-2, which complicate accurate diagnosis highlight need improved testing surveillance practices. To end, multiple regional, national, global virologic systems have been established provide knowledge viral support preparedness response potential outbreaks, help inform prevention reduce severity transmission. Beyond illness, long-term health consequences also result from SARS-CoV-2 infection. These cardiovascular pulmonary complications, worsening existing chronic conditions, increased frailty, reduced life expectancy. place a financial society healthcare systems. Collectively, indicate present challenge, underscoring interventions improve outcomes illnesses.Graphical abstract video available article.

Язык: Английский

Процитировано

1
Lingering effects of COVID-19 in the care of perioperative patients DOI

Linjia Jia,

Sagar Navare,

Marguerite Hoyler

и другие.

Current Opinion in Anaesthesiology, Год журнала: 2024, Номер 37(3), С. 308 - 315

Опубликована: Март 8, 2024

Coronavirus disease 2019 (COVID-19), caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), can lead to organ dysfunction and clinical symptoms beyond infection phase. These effects may have significant implications for management of perioperative patients. The purpose this article is provide a systems-based approach subacute chronic SARS-CoV-2 that are most relevant anesthesiology practice.

Язык: Английский

Процитировано

0
Association between inflammatory markers, body composition and frailty in home-dwelling elderly: an 8-year follow-up study DOI Creative Commons

Pia Bålsrud,

Stine M. Ulven, Inger Ottestad

и другие.

GeroScience, Год журнала: 2024, Номер 46(6), С. 5629 - 5641

Опубликована: Июль 9, 2024

Abstract Frailty has been linked to inflammation and changes in body composition, but the findings are inconsistent. To explore this, we used Index (FI) definition (1) investigate association between levels of inflammatory markers (baseline) change FI score after 8 years follow-up (2) longitudinal associations markers, frailty. Home-dwelling elderly (≥ 70 years) were invited participate study re-invited a visit later. This includes total 133 participants. The included high-sensitive C-reactive protein (hs-CRP), interleukin 6 (IL-6), tumor necrosis factor alpha (TNF-α), glycoprotein acetyls (Gp-acetyls). We composition fat mass, fat-free waist circumference. consisted 38 variables. Additional clinical assessments such as blood pressure mass index (BMI), well information about daily medications, collected at both visits. Linear regression model Spearman’s rank correlation associations. showed that increased years, participants with higher hs-CRP baseline had largest score. Changes significantly correlated IL-6, circumference TNF-α. use drugs during follow-up, which may have attenuated However, elevated concentrations be associated an risk frailty subsequent years.

Язык: Английский

Процитировано

0