Abstract
Ferroptosis
is
associated
with
the
occurrence
and
development
of
many
diseases,
which
result
an
imbalance
in
cellular
metabolism
oxidation−reduction
balance.
Therefore,
it
effective
therapeutic
strategy
that
simultaneously
regulating
intracellular
system.
Herein,
a
click
reaction
alkynylamide
thiol
groups
presence
amine
or
PBS
(pH
=
7.4)
developed,
can
react
efficiently
substances,
such
as
cysteine
(Cys),
glutathione
(GSH),
bovine
serum
albumin
(BSA).
Notably,
MBTB‐PA,
aggregation‐induced
emission
(AIE)
photosensitizer
unit,
synthesized
its
behavior
visualized
situ
by
fluorescence
imaging,
demonstrating
excellent
ability
to
target
endoplasmic
reticulum.
Furthermore,
MBTB‐PA
reacted
proteins
tumor
cells,
consumed
reducing
triggered
oxidative
stress,
resulting
cell
death.
Based
on
this
therapy
strategy,
combined
photodynamic
achieve
killing
cells
raising
state
reductive
state.
This
work
not
only
develops
application
alkynamide
bioconjugation
anti‐tumor
therapy,
but
also
provides
feasible
ideas
for
organic
reactions
exploration
organisms.
ACS Nano,
Год журнала:
2023,
Номер
17(15), С. 14800 - 14813
Опубликована: Июль 24, 2023
The
development
of
functional
materials
for
tumor
immunogenicity
enhancement
is
desirable
overcoming
the
low
therapeutic
efficiency
and
easy
metastasis
during
treatments.
Herein,
thermoresponsive
nanoparticles
composed
photothermal
agent
(PTA)
click
reactive
reagent
are
developed
enhanced
immunotherapy
application.
A
Ni-bis(dithiolene)-containing
PTA
with
intense
near-infrared
absorption
efficient
conversion
construction.
generated
heat
by
encapsulated
further
induces
phase
transition
release
chemotherapy
to
react
amino
groups
on
proteins,
realizing
PTT
simultaneously.
Moreover,
immunogenic
cell
death
(ICD)
cancer
cells
evoked
could
be
released
reagent.
As
a
result,
synergistic
effect
treatment
reaction-mediated
can
suppress
growth
primary
tumor,
ICD
activate
immune
response
suppression
distant
tumor.
This
strategy
provides
reliable
promising
approach
in
clinic.
Advanced Materials,
Год журнала:
2024,
Номер
36(31)
Опубликована: Июнь 6, 2024
Abstract
The
recent
success
of
gene
therapy
during
the
COVID‐19
pandemic
has
underscored
importance
effective
and
safe
delivery
systems.
Complementing
lipid‐based
systems,
polymers
present
a
promising
alternative
for
delivery.
Significant
advances
have
been
made
in
past,
with
multiple
clinical
trials
progressing
beyond
phase
I
several
companies
actively
working
on
polymeric
systems
which
provides
assurance
that
carriers
can
soon
achieve
translation.
massive
advantage
structural
tunability
vast
chemical
space
is
being
leveraged
to
mitigate
shortcomings
traditional
polycationic
improve
translatability
Tailored
approaches
diverse
nucleic
acids
specific
subcellular
targets
are
now
designed
therapeutic
efficacy.
This
review
describes
polymer
design
improved
by
polyplexes
covalent
polymer‐nucleic
acid
conjugates.
also
offers
brief
note
novel
computational
techniques
design.
concludes
an
overview
current
state
therapies
clinic
as
well
future
directions
their
translation
clinic.
Journal of Polymer Science,
Год журнала:
2023,
Номер
62(5), С. 787 - 798
Опубликована: Сен. 5, 2023
Abstract
Dynamic
covalent
polymers
have
gained
more
and
attention
for
their
fascinating
dynamic
features
broad
application
prospects.
As
an
emerging
powerful
synthetic
tool,
X‐yne
click
polymerization,
mainly
including
thiol‐yne,
amino‐yne
hydroxyl‐yne
polymerizations,
has
been
rapidly
developed
widely
applied
in
the
preparation
of
functional
recent
years.
Moreover,
exchange
processes
successively
observed
different
adducts,
then
several
obtained
by
polymerization.
The
combination
these
two
aspects
not
only
provides
a
highly
efficient
approach
polymers,
but
also
further
expands
scope
achieving
win–win
situation.
In
this
review,
we
sort
out
mechanisms
based
on
formation
β
‐heteroatom
enolate
intermediates
give
detailed
account
progress
generated
from
polymerization
applications
adaptable
networks
(CANs),
self‐healing
injectable
polymer
hydrogels
porous
polymeric
films,
etc.
existing
deficiencies
future
prospects
field
are
discussed.
Angewandte Chemie International Edition,
Год журнала:
2023,
Номер
62(52)
Опубликована: Ноя. 10, 2023
Abstract
The
click
reaction
has
found
good
utility
across
various
fields
due
to
the
characteristics
of
high
efficiency,
atom
economy,
simple
and
mild
conditions.
Click
chemistry
is
usually
utilized
for
connecting
components
microscopic
level,
while
it
still
unable
joining
macroscopic
building
blocks.
Materials
consisting
blocks
realize
flexible
fabrication
three‐dimensional
structures
at
exerting
significance
on
parallel
manufactures.
In
this
work,
we
reported
utilizing
hydrogel
as
Hydrogels
G1
G2
were
prepared
by
incorporating
M1
(
N
,
′‐dimethyl‐1,2‐ethanediamine)
P1
(alkyne
functionalized
polyethylene
glycol)
respectively,
where
polymer
chains
formed
through
diffusion‐induced
amino‐yne
entangled
different
networks
together.
Additionally,
chain‐like
aggregates
complicated
3D
such
tetrahedron
quadrangular
pyramid
constructed
based
adhesion
approach
enables
us
find
more
possibilities
in
delicate
designation
aggregations
well
large‐scale
manufacturing.
Abstract
The
“laboratory”
of
cells
has
the
capacity
to
polymerize
monosaccharides,
amino
acids,
and
nucleotides.
Tumor
cells,
characterized
by
overexpression
multiple
enzymes
existing
in
a
slightly
acidic
highly
redox‐potent
environment,
have
attracted
attention
chemists
aiming
transfer
chemical
reactions
from
traditional
laboratory
flask
this
“cellular
laboratory”.
Polymers,
resulting
repetitive
linkage
monomers,
garnered
extensive
utility
biomedical
field
due
their
diverse
structural
physicochemical
properties.
When
polymerization
reaction
proceeds
situ
within
tumor
transformation
small‐to‐large
combines
rapid
uptake
monomeric
molecules
with
strong
retention
ability
polymers,
exerting
profound
impact
on
drug
delivery
tumors.
Moreover,
it
shows
promising
applications
regulation
cell
behavior,
imaging,
therapy,
theranostics.
Given
functions
relation
review
focuses
comprehensive
examination
various
strategies
for
categorizing
these
based
formation
mechanisms
polymers.
domain
concerning
are
also
explored.
discussion
specific
limitations
current
research
insights
into
potential
future
directions
authors'
perspective
provided.
Macromolecules,
Год журнала:
2024,
Номер
57(8), С. 3824 - 3830
Опубликована: Апрель 10, 2024
Due
to
the
combination
of
flexibility
and
mobility,
polycatenanes
have
potential
in
constructing
various
functional
materials.
To
date,
most
previous
works
reported
poly[2]catenanes
with
a
degree
polymerization
(DP)
around
20.
However,
it
remains
significant
challenge
synthesize
higher
DP
value.
Hydroxyl–yne
click
polymerization,
bearing
merits
obtaining
polymers
high
values,
short
reaction
time,
mild
condition,
is
promising
be
employed
preparing
values.
Herein,
strategy
using
hydroxyl–yne
chemistry
fabricate
was
proposed.
With
two
hydroxyl
groups
on
both
rings,
[2]catenane
monomer
M1
prepared.
Meanwhile,
hexaethylene
glycol
alkyne
functionalized
as
M2.
bicyclo[2.2.2]-1,4-diazaoctane
(DABCO)
catalyzing,
M2
reacted
via
at
room
temperature.
The
resultant
poly[2]catenane
reached
up
36.
In
addition,
tetraphenylethylene
(TPE)
modified
propiolic
acid
obtain
M3.
Then,
poly([2]catenane-alt-TPE)
aggregation-induced
emission
(AIE)
properties
obtained
between
M3
well.
Journal of the American Chemical Society,
Год журнала:
2024,
Номер
146(10), С. 6652 - 6664
Опубликована: Фев. 29, 2024
Nitrile
compounds
are
abundant,
stable,
cheap,
and
readily
available
natural
chemical
industrial
sources.
However,
the
efficient
conversion
of
nitrile
monomers
to
functional
polymers
is
mostly
limited
due
their
inert
reactivity,
developing
polymerizations
based
on
under
very
mild
conditions
still
a
big
challenge.
In
this
work,
facile
powerful
base-catalyzed
acetonitrile-azide
click
polymerization
was
successfully
established
ambient
conditions.
This
also
enjoys
merits
short
reaction
time
(15
min),
100%
atom
economy,
transition-metal-free
catalyst
system,
regioselectivity.
A
series
poly(5-amino-1,2,3-triazole)s
(PATAs)
with
high
weight-average
molecular
weights
(Mw,
up
204,000)
were
produced
in
excellent
yields
(up
99%).
The
PATAs
containing
tetraphenylethene
(TPE)
moieties
exhibit
unique
aggregation-induced
emission
(AIE)
characteristics,
which
could
be
used
sensitively
detect
Fe(III)
ions
low
limit
detection
(1.205
×
10–7
M)
specifically
image
lysosomes
living
cells.
Notably,
facilely
post-modified
primary
amino
groups
polymer
chains
even
through
one-pot
tandem
reaction.
Thus,
work
not
only
establishes
new
convert
stable
nitriles
but
generates
versatile
properties
for
diverse
applications.
