Pyridinyl Polythioether via a One-Pot Thiolactone Ring-Opening and Thiol-Phenylsulfone Click Polymerization: Synthesis, Fluorescence, and Degradation Behavior

Macromolecules, Год журнала: 2025, Номер unknown

Опубликована: Фев. 12, 2025

Язык: Английский

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Lab‐in‐Cell: A Covalent Photosensitizer Reverses Hypoxia and Evokes Ferroptosis and Pyroptosis for Enhanced Anti‐Tumor Immunity

Advanced Materials, Год журнала: 2025, Номер unknown

Опубликована: Фев. 23, 2025

Abstract Photodynamic immunotherapy presents a non‐invasive strategy characterized by spatiotemporal control and minimal side effects to induce immunogenic cell death (ICD). This approach significantly enhances the release of tumor‐associated antigens damage‐associated molecular patterns, thereby improving cancer outcomes. However, hypoxia antioxidant defenses at tumor sites considerably diminish efficacy photodynamic immunotherapy. In this work, covalent warhead, alkyneamide, is introduced into an AIE photosensitizer develop novel photosensitizer, MBTP‐PA, which targets redox systems facilitates ferroptosis‐ pyroptosis‐mediated thiol‐yne click reactions. The interacts with intracellular thiol compounds such as cysteine glutathione, disrupting system alleviating hypoxia. results in enhanced therapy (PDT) compared non‐covalent MBTP‐A. Furthermore, conjunction PDT, reaction can activate ICD through ferroptosis pyroptosis, enhancing anti‐tumor immunity. Notably, vivo injection MBTP‐PA nanoparticles site led elimination primary tumors, inhibiting distal tumors exhibiting effects. Therefore, work not only integrates reactions cellular systems, but also paves way for developing photosensitizers.

Язык: Английский

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Multicomponent Polymerizations Provide Sustainable Sulfur (Selenium)-Containing Polyesters

Accounts of Chemical Research, Год журнала: 2025, Номер unknown

Опубликована: Март 31, 2025

ConspectusWith the rapid development of polymer industry, contradiction between synthetic polymers and sustainable human society is becoming more prominent. The advancement degradable plastics greatly contributes to sustainability our society. Synthetic containing precisely placed in-chain ester groups are expected be in a controlled manner. Their potential as environmentally benign significant. For this purpose, there clear need for their improved performance. Incorporating sulfur functional into polyesters can improve diverse crucial properties counterparts. However, lack related high-efficiency synthesis methods.In response issue, we designed series multicomponent polymerization methods library with tunable structure properties. This Account summarizes recent efforts discover approach. method uses readily available monomers including diols, diamines, H2O, diacrylates, carbonyl sulfide (COS), cyclic thioanhydrides, CO, selenium powder. usually carried out under mild conditions: at 60 90 °C, 2 12 h, using organobases catalysts or catalyst-free. approach achieves simultaneous incorporation sulfur/selenium thiocarbonate, thioether, thioester, thiourethane, selenoether.The has wide monomer scope yields structures. obtained possess weight-average molecular weights up 175.4 kDa. Most these thermally stable, exhibiting decomposition temperatures >200 °C. Due diversity structure, demonstrate extensively performance covering crystalline plastics, thermoplastic elastomers, amorphous plastics. These exhibit range glass-transition -60 72 °C melting 43 274 Notably, long alkyl chains (number carbon atoms ≥ 9) polyethylene-like crystallinity mechanical thiourethane amide enable enhanced thermal due inter/intramolecular hydrogen bonding. also easy degrade via alkali hydrolysis, alcohol enzymatic oxidation, etc. degradation products often have well-defined value-added even directly used repolymerization achieve closed-loop chemical cycle. Overall, presented furnishes facile versatile

Язык: Английский

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Recent Advances in Aggregation-Induced Emission Bioconjugates

Bioconjugate Chemistry, Год журнала: 2025, Номер unknown

Опубликована: Апрель 1, 2025

Fluorescence imaging technology is playing increasing roles in modern personalized and precision medicine. Thanks to their excellent photophysical properties, organic luminogens featuring aggregation-induced emission (AIE) characteristics (AIEgens) have attracted considerable attention over the past two decades. Because of superior biocompatibility, ease processing functionalization, water solubility, high responsiveness, exceptional signal-to-noise ratio (SNR) for biotargets, AIE bioconjugates, formed by covalently linking AIEgens with biomolecules, emerged as an ideal candidate bioapplications. In this review, we summarize progress preparation, application bioconjugates last five years. Moreover, challenges opportunities are also briefly discussed.

Язык: Английский

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Organobase-Catalyzed Carboxyl-yne Click Polymerization

ACS Macro Letters, Год журнала: 2025, Номер unknown, С. 551 - 557

Опубликована: Апрель 19, 2025

Polyesters have been widely used in the biological and engineering fields. However, polycondensations require high reaction temperatures long times, ring-opening polymerizations are generally intolerant to functional groups. Therefore, development of a new polymerization toward polyesters under mild conditions will further promote their development. In this work, we established organobase-catalyzed click ester-activated alkynes bis(carboxylic acid)s conditions, regio- stereoregular poly(β-acyloxyacrylate)s with weight-average molecular weights up 24200 were obtained yields 96%. The resultant polymers show versatile properties. aliphatic exhibit crystalline behavior, whereas aromatic demonstrate thermal stability. polymer containing tetraphenylethene units exhibits trade-off refractive index Abbé Number. Thanks dynamic nature β-acyloxyacrylate units, could be quickly degraded upon addition phenol derivatives organobase, which applied fabrication fluorescent photopatterns. Thus, work not only provides powerful facile for postmodification materials carbonyl groups, but also enriches family X-yne polymerization.

Язык: Английский

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