Angewandte Chemie,
Год журнала:
2024,
Номер
137(1)
Опубликована: Сен. 21, 2024
Abstract
Phototheranostics
is
growing
into
a
sparking
frontier
in
disease
treatment.
Developing
single
molecular
species
synchronously
featured
by
powerful
absorption
capacity,
superior
second
near‐infrared
(NIR‐II)
fluorescence
and
prominent
photothermal
conversion
ability
highly
desirable
for
phototheranostics,
yet
remains
formidably
challenging.
In
this
work,
we
propose
design
philosophy
that
the
integration
of
noncovalent
conformational
locks
(NoCLs)
with
aggregation‐induced
emission
(AIE)
formulation
able
to
boost
multiple
photophysical
properties
efficient
phototheranostics.
The
introduction
NoCLs
skeleton
conformation‐locking
feature
center
architecture
indeed
elevates
structural
planarity
rigidity,
which
simultaneously
promotes
capacity
bathochromic‐shifts
wavelength
centered
NIR‐II
region.
Meanwhile,
AIE
tendency
mainly
originated
from
flexibly
propeller‐like
geometry
at
ends
eventually
endows
molecule
satisfactory
intensity
aggregates.
Consequently,
utilizing
optimized
molecule,
unprecedented
performance
on
fluorescence‐photoacoustic‐photothermal
trimodal
imaging‐guided
photothermal‐chemo
synergistic
therapy
demonstrated
precise
tumor
diagnosis
complete
ablation.
Angewandte Chemie International Edition,
Год журнала:
2024,
Номер
unknown
Опубликована: Ноя. 9, 2024
The
contradiction
of
near-infrared
II
(NIR-II)
emission
and
photothermal
effects
limits
the
development
phototheranostic
agents
(PTAs)
in
many
emerging
cutting-edge
applications.
Organic
aggregates
present
a
promising
opportunity
for
balance
competitive
relaxation
processes
through
manipulation
molecular
structure
packing.
Herein,
side
chain
phenyl
isomerization-induced
spatial
conjugation
was
proposed
constructing
A-D-A
type
NIR-II
PTAs
with
simultaneous
enhancement
fluorescence
brightness
properties.
Three
pairs
mutually
isomeric
fluorophores,
whose
phenyls
respectively
located
at
outside
(o-series)
inside
(i-series)
chain,
were
designed
synthesized.
positional
isomerization
endows
o-series
crystals
strong
between
group
on
backbone,
as
well
interlocked
planar
network,
which
is
different
to
that
observed
i-series.
Thus,
all
nanoparticles
(NPs)
exhibit
red-shifted
absorption,
enhanced
emission,
superior
properties
than
their
i-series
counterparts.
A
prominent
member
o-series,
o-ITNP
NPs,
demonstrated
efficacy
facilitating
angiography,
tumor
localization,
imaging-guided
therapy.
success
this
strategy
paves
way
precise
control
aggregation
behavior
further
efficient
PTAs.
Research Square (Research Square),
Год журнала:
2024,
Номер
unknown
Опубликована: Июль 25, 2024
Abstract
Background
Nanodrug
delivery
systems
offer
promising
solutions
to
the
limitations
of
conventional
treatments
for
rheumatoid
arthritis
(RA)
and
type
2
Diabetes
Mellitus
(T2DM).
Among
nanoparticles,
niosomes
are
particularly
effective
due
their
stability,
ease
preparation,
ability
reduce
systemic
toxicity.
They
provide
controlled
drug
release
enhance
solubility
stability
pharmaceutical
compounds.
Incorporating
hyaluronic
acid
(HA)
into
can
further
efficacy
by
targeting
specific
cells,
improving
delivery,
increasing
therapeutic
impact.
In
this
study,
metformin,
a
common
T2DM
medication,
was
effectively
delivered
using
HA-coated
niosomes,
demonstrate
potential
approach
in
treating
RA
patients
with
T2DM.
Methods
Peripheral
blood
mononuclear
cells
(PBMCs)
were
extracted
from
samples
patients,
T2DM,
healthy
individuals.
Metformin-loaded
niosomal
nanoparticles
(Nio-met
NPs)
synthesized
thin-film
hydration
method
modified
Hyalo-Nio-met
NPs
adding
acid.
The
pattern
metformin
studied,
these
characterized
Dynamic
Light
Scattering
(DLS),
Scanning
Electron
Microscopy
(SEM),
Atomic
Force
(AFM),
Fourier
Transform
Infrared
Spectroscopy
(FT-IR).
Factors
like
reactive
oxygen
species
(ROS),
interleukin-23
(IL-23),
nuclear
factor
activated
T-cells
cytoplasmic
1
(NFATc1),
receptor
activator
kappa-Β
ligand
(RANKL),
cyclooxygenase-2
(COX-2)
assessed
both
treated
untreated
PBMCs.
Results
exhibited
spherical
morphology
sizes
179
±
8.5
nm,
polydispersity
index
(PDI)
0.663,
zeta
-9.76
3.4
mV.
FT-IR
analysis
confirmed
encapsulation
within
NPs.
Approximately
68%
loaded
released
Hyalo-niosomal
after
120
hours.
Treatment
led
significant
reduction
(ROS)
level
decreased
activity
pro-inflammatory
cytokine
(IL-23)
inflammation-related
genes
(NFATc1,
RANKL,
COX-2).
Conclusion
Taken
together
system
acceptable
terms
characteristics
vicinity
treatment
demonstrated
notable
inflammatory
markers
an
enhancement
anti-inflammatory
antioxidant
defenses
PBMCs
Abstract
In
recent
years,
the
substantial
increase
in
total
joint
replacements
for
treating
degenerative
disease
has
heightened
concerns
regarding
implant
loosening
and
failure.
This
is
especially
critical
as
more
young
patients
are
undergoing
both
initial
subsequent
replacement
procedures.
These
complications
often
necessitate
additional
revision
surgeries.
Unfortunately,
current
clinical
practices
lack
effective
methods
early
detection
of
failure,
there
a
noticeable
absence
strategies
utilizing
molecular
markers
to
identify
post‐surgery
issues.
article
critically
assesses
potential
aggregation‐induced
emission
(AIE)
biomarkers
detecting
relevant
It
begins
by
outlining
pathogenesis
identifying
pertinent
markers.
The
study
then
delves
into
how
AIE
luminogens
(AIEgens)
can
play
crucial
role
processes
such
osteogenesis
osteoclastogenesis.
Notably,
it
discusses
utilization
AIEgens
key
markers,
including
TNF‐α,
osteocalcin,
urinary
N‐terminal
telopeptide.
prospect
bone
loss
failure
presents
promising
avenue
enhancing
our
understanding
skeletal
health
improving
outcomes
through
timely
intervention
personalized
treatment
approaches.
Ongoing
research
development
this
area
translating
AIE‐based
technologies
practical
tools
optimizing
management.
Angewandte Chemie,
Год журнала:
2024,
Номер
137(1)
Опубликована: Сен. 21, 2024
Abstract
Phototheranostics
is
growing
into
a
sparking
frontier
in
disease
treatment.
Developing
single
molecular
species
synchronously
featured
by
powerful
absorption
capacity,
superior
second
near‐infrared
(NIR‐II)
fluorescence
and
prominent
photothermal
conversion
ability
highly
desirable
for
phototheranostics,
yet
remains
formidably
challenging.
In
this
work,
we
propose
design
philosophy
that
the
integration
of
noncovalent
conformational
locks
(NoCLs)
with
aggregation‐induced
emission
(AIE)
formulation
able
to
boost
multiple
photophysical
properties
efficient
phototheranostics.
The
introduction
NoCLs
skeleton
conformation‐locking
feature
center
architecture
indeed
elevates
structural
planarity
rigidity,
which
simultaneously
promotes
capacity
bathochromic‐shifts
wavelength
centered
NIR‐II
region.
Meanwhile,
AIE
tendency
mainly
originated
from
flexibly
propeller‐like
geometry
at
ends
eventually
endows
molecule
satisfactory
intensity
aggregates.
Consequently,
utilizing
optimized
molecule,
unprecedented
performance
on
fluorescence‐photoacoustic‐photothermal
trimodal
imaging‐guided
photothermal‐chemo
synergistic
therapy
demonstrated
precise
tumor
diagnosis
complete
ablation.
