ACS Nano, Год журнала: 2024, Номер 18(45), С. 31286 - 31299
Опубликована: Окт. 30, 2024
Controllable carbon monoxide (CO) release simulated by light-generated reactive oxygen species (ROS) represents a promising approach for cancer therapy but is hampered low CO rate and ROS generation of conventional photosensitizers in hypoxia tumor microenvironments. In this study, we developed highly efficient nanoplatform (TPyNO
Язык: Английский
Chemical & Biomedical Imaging, Год журнала: 2025, Номер unknown
Опубликована: Фев. 14, 2025
Язык: Английский
Процитировано
0
Colloids and Surfaces A Physicochemical and Engineering Aspects, Год журнала: 2025, Номер unknown, С. 136477 - 136477
Опубликована: Фев. 1, 2025
Язык: Английский
Процитировано
0
Advanced Materials, Год журнала: 2025, Номер unknown
Опубликована: Фев. 23, 2025
Abstract Photodynamic immunotherapy presents a non‐invasive strategy characterized by spatiotemporal control and minimal side effects to induce immunogenic cell death (ICD). This approach significantly enhances the release of tumor‐associated antigens damage‐associated molecular patterns, thereby improving cancer outcomes. However, hypoxia antioxidant defenses at tumor sites considerably diminish efficacy photodynamic immunotherapy. In this work, covalent warhead, alkyneamide, is introduced into an AIE photosensitizer develop novel photosensitizer, MBTP‐PA, which targets redox systems facilitates ferroptosis‐ pyroptosis‐mediated thiol‐yne click reactions. The interacts with intracellular thiol compounds such as cysteine glutathione, disrupting system alleviating hypoxia. results in enhanced therapy (PDT) compared non‐covalent MBTP‐A. Furthermore, conjunction PDT, reaction can activate ICD through ferroptosis pyroptosis, enhancing anti‐tumor immunity. Notably, vivo injection MBTP‐PA nanoparticles site led elimination primary tumors, inhibiting distal tumors exhibiting effects. Therefore, work not only integrates reactions cellular systems, but also paves way for developing photosensitizers.
Язык: Английский
Процитировано
0
The Journal of Physical Chemistry Letters, Год журнала: 2025, Номер 16(9), С. 2273 - 2282
Опубликована: Фев. 24, 2025
Modern photodynamic therapy (PDT) demands next-generation photosensitizers (PSs) that overcome heavy-atom dependency and enhance efficacy beyond traditional, highly oxygen-dependent type II mechanisms. We introduce herein TCI-NH, as a thiochromenocarbazole imide derivative designed for I action. Upon light activation, TCI-NH efficiently favors superoxide (O2•-) PS-centered radical formation instead of singlet oxygen (1O2) generation. Its high luminescence efficiency selective localization in both the endoplasmic reticulum mitochondria enable precise, image-guided PDT. Notably, interactions with biomolecules, such serum albumin or DNA, TCI-NH's emission by up to 40-fold amplify generation 5-fold. With negligible dark toxicity, this results ∼120 nM photocytotoxicity along an impressive phototherapeutic index exceeding 200. Real-time live-cell imaging revealed rapid, light-triggered cytotoxicity characterized apoptotic body extensive cellular damage. its small size, heavy-atom-free structure, exceptional, organelle specificity, therapeutic efficacy, sets new benchmark anticancer
Язык: Английский
Процитировано
0
Nano-Micro Letters, Год журнала: 2025, Номер 17(1)
Опубликована: Март 10, 2025
Abstract The treatment of ammonia nitrogen wastewater (ANW) has garnered significant attention due to the ecology, and even biology is under increasing threat from over discharge ANW. Conventional ANW methods often encounter challenges such as complex processes, high costs secondary pollution. Considerable progress been made in employing solar-induced evaporators for treatment. However, there remain notable barriers transitioning fundamental research practical applications, including insufficient evaporation rates inadequate resistance biofouling. Herein, we propose a novel evaporator, which comprises bio-enzyme-treated wood aerogel that serves water pumping storage layer, cost-effective multi-walled carbon nanotubes coated hydrophobic/hydrophilic fibrous nonwoven mat functioning photothermal aggregation-induced emission (AIE) molecules incorporated anti-biofouling agent. resultant bioinspired evaporator demonstrates rate 12.83 kg m −2 h −1 when treating simulated containing 30 wt% NH 4 Cl 1.0 sun illumination. AIE-doped exhibits remarkable photodynamic antibacterial activity against mildew bacteria, ensuring outstanding biofouling extended periods When enhanced by natural wind irradiation, achieves an impressive exceeding 20 . This advancement represents promising viable approach effective removal wastewater.
Язык: Английский
Процитировано
0
Aggregate, Год журнала: 2025, Номер unknown
Опубликована: Март 4, 2025
ABSTRACT Alzheimer's disease (AD) is one of the most prevalent forms neurodegenerative disease. Although some controversy exists, β‐amyloid peptide (Aβ) recognized to play an essential role in pathophysiology AD. The Aβ species are known exist various forms, including soluble monomers, oligomers, and insoluble aggregates. Despite extensive efforts regulate aggregation, no successful medications have been developed date. Among strategies for AD treatment, phototherapy, photodynamic therapy (PDT), photothermal (PTT), photopharmacology, photobiomodulation (PBM) attracted increased attention because spatiotemporal controllability. Representative examples PDT, PTT, PBM discussed terms inhibitory mechanism, unique properties materials, design phototherapy modulators. major challenges against addressed promising prospects proposed. It concluded that noninvasive light‐assisted approaches will become a strategy intensifying modulation aggregation or promoting clearance thus facilitating treatment.
Язык: Английский
Процитировано
0
Molecules, Год журнала: 2025, Номер 30(6), С. 1274 - 1274
Опубликована: Март 12, 2025
The smart construction of nano-photosensitizers (PSs) is significant for multipurpose applications, such as bioimaging, efficient photodynamic anti-tumor or anti-bacterial studies. This work reports a flexible self-assembling strategy the nano-PSs, in which PSs spontaneously form amorphous aggregates killing bacteria, self-assemble with tetraphenylethene (TPE) based glycoclusters (TPE-Glc4) to construct glyco-dots cell imaging and Tricyanofuran (TCF) TPE units were bridged furan thiophene moiety two (1 2) NIR fluorescence monomers, performance aggregation-induced generation reactive oxygen species (AIG-ROS) an aggregated state. Compared large (2-a), TPE-based encapsulated PS (2-Glc) that exhibit smaller more homogeneous hydrated size approximately 40 nm, well enhanced water-solubility biocompatibility. TPE-glycoclusters facilitate cellular uptake 2 into HepG2 cells, therefore enhancing signal therapy. Meanwhile, 2-a exhibits satisfied phototoxicity against Escherichia coli. highlights self-assembly nano-PSs multifunctional bioapplications.
Язык: Английский
Процитировано
0
Chemical Engineering Journal, Год журнала: 2025, Номер unknown, С. 161784 - 161784
Опубликована: Март 1, 2025
Язык: Английский
Процитировано
0
AMB Express, Год журнала: 2025, Номер 15(1)
Опубликована: Март 28, 2025
Photodynamic therapy (PDT) is an innovative, non-invasive, and selective treatment approach that has gained attention as adjunctive in periodontitis. Aggregatibacter actinomycetemcomitans opportunistic periodontopathogen known for its ability to form biofilms. The objective of this vitro study was determine the anti-virulence effect nano-quercetin (N-QT)-mediated PDT on expression a gene associated with biofilm formation A. actinomycetemcomitans. After synthesis characterization N-QT by transmission electron microscopes (TEM), dynamic light scattering (DLS), zeta potential analysis, fourier transform infrared spectroscopy (FTIR) effects different concentrations energy densities diode laser alone cell viability were evaluated. then treated sub-lethal doses emitting presence N-QT. Ultimately, dose used investigate metabolic activity actinomycetemcomitans, generation reactive oxygen species (ROS), changes rcpA, qseB, qseC genes using quantitative real-time polymerase chain reaction (qRT-PCR) method. According results, TEM, DLS, potential, FTIR confirmed 16 512 µg/mL irradiation 6 min density 154.8 J/cm2 caused significant decrease bacterial count (P < 0.05). 8 5-min achieved highest reduction (42.9%), while 2 4-min yielded lowest (12.3%). Using exposure 4 5 at 103.9 129 J/cm² led ROS levels 2.67- 2.83-fold higher than those control cells, respectively Additionally, resulted 2.62-, 2.85-, 3.21-fold genes, utilizing shows promise suppressing cellular survival emerges viable strategy targeting virulence.
Язык: Английский
Процитировано
0
ChemistrySelect, Год журнала: 2025, Номер 10(15)
Опубликована: Апрель 1, 2025
Abstract This study introduces innovative redox‐sensitive polymeric nanocarriers designed to deliver the photosensitizer meso ‐tetra( N ‐methyl‐4‐pyridyl)porphine and enhance anticancer photodynamic therapy. These release from a hydrophobic core in response elevated glutathione levels, enabling generation of reactive oxygen species upon irradiation. The glutathione‐sensitive is constructed using disulfide‐linked molecules, while hydrophilic shell, consisting 6‐methyluracil derivative, enhances stability promotes cellular uptake photosensitizer. paper details synthesis, physicochemical properties, encapsulation efficiency nanocarriers. It further explores how structure influences glutathione‐induced degradation, kinetics, under Additionally, evaluates hemocompatibility photosensitizer/nanocarrier composites their cytotoxic effects on human liver cells (Chang Liver), healthy embryonic lung (WI38), cancer cell lines (M‐HeLa HuTu80). Notably, treatment with these composites, followed by irradiation, significantly reduces viability M‐HeLa line, demonstrating potential for targeted
Язык: Английский
Процитировано
0