Metal‐Protein Hybrid Materials: Unlocking New Frontiers in Biomedical Applications
Advanced Healthcare Materials,
Год журнала:
2025,
Номер
unknown
Опубликована: Янв. 7, 2025
Abstract
Metal‐protein
hybrid
materials
represent
a
novel
class
of
functional
that
exhibit
exceptional
physicochemical
properties
and
tunable
structures,
rendering
them
remarkable
applications
in
diverse
fields,
including
engineering,
biocatalysis,
biosensing,
biomedicine.
The
design
development
multifunctional
biocompatible
metal‐protein
have
been
the
subject
extensive
research
key
aspiration
for
practical
clinical
settings.
This
review
provides
comprehensive
analysis
strategies,
intrinsic
properties,
biomedical
these
materials,
with
specific
emphasis
on
their
potential
cancer
therapy,
drug
vaccine
delivery,
antibacterial
treatments,
tissue
regeneration.
Through
rational
design,
stable
can
be
synthesized
using
straightforward
methods,
enabling
therapeutic,
immunomodulatory,
other
desired
functionalities.
Finally,
outlines
existing
limitations
challenges
associated
evaluates
translation,
providing
insights
into
implementation
within
applications.
Язык: Английский
Fabricating N-Cadherin Mimetic Peptide-Based Diverse Self-Assembled Hydrogels in the Presence of Biologically Relevant Cations
Biomacromolecules,
Год журнала:
2025,
Номер
unknown
Опубликована: Март 18, 2025
N-cadherin,
a
crucial
extracellular
matrix
protein,
is
in
mediating
cellular
interactions
and
promoting
cell
migration.
Herein,
we
have
attempted
to
create
N-cadherin
mimetic
peptide
(NcMP)
hydrogel
scaffolds
by
incorporating
cations
as
the
external
stimulus
suitable
interface
for
favorable
interactions.
Inspired
Hofmeister
series,
selected
four
biologically
significant
cations,
classified
kosmotropes
chaotropes,
varied
their
concentrations
investigate
how
increasing
ionic
strength
affects
self-assembly
of
NcMP.
Interestingly,
incorporation
these
ions
greatly
influenced
self-assembling
propensity
Fmoc-HAVDI
hydrogel,
which
resulted
diverse
structural
mechanical
properties.
Such
physical
properties
led
differential
responses.
Thus,
were
able
access
biological
single
gelator
molecule
simply
changing
nature
concentration
relevant
cations.
We
anticipate
that
systems
hold
great
potential
various
biomedical
applications.
Язык: Английский
Fabrication and characterization of chitosan/Ag@hydroxyapatite nanocomposite films for Osteoregeneration: Insights into Mechanical Properties, biological Performance, and Drug Release
Gowri Rengasamy,
Sundrarajan Mahalingam
Colloids and Surfaces A Physicochemical and Engineering Aspects,
Год журнала:
2025,
Номер
unknown, С. 136790 - 136790
Опубликована: Март 1, 2025
Язык: Английский
Transition metal carbonates/oxalates for advanced lithium storage: optimization strategies, further faradic reactions and capacitive/interfacial charge storage
Nano Energy,
Год журнала:
2025,
Номер
unknown, С. 110928 - 110928
Опубликована: Апрель 1, 2025
Язык: Английский
Design of Short Peptides for the Reduction of Silver Ions and Stabilization of Nanocomposites in Combating Bacterial Infections
ChemBioChem,
Год журнала:
2025,
Номер
unknown
Опубликована: Апрель 4, 2025
Combating
bacterial
infections
has
become
a
formidable
challenge
in
healthcare
due
to
the
rise
of
antibiotic
resistance.
Recently,
short
peptide-based
nanobiomaterials,
assembled
through
silver
metal
and
peptide
building
blocks,
have
emerged
as
promising
agents
for
treating
resistant
infections.
In
this
minireview,
recent
advances
silver-peptide
nanocomposites
are
highlighted,
both
with
without
assistance
UV
or
sunlight,
antibacterial
applications.
The
chemical
design
biomolecules
such
amphiphilic
peptides,
amino
acids,
oligopeptides
plays
crucial
role
reduction,
stabilization,
biocompatibility
nanocomposites.
Noncovalent
interactions
involved
formation
explored
context
structure-function
relationship.
activities
underlying
mechanisms,
which
depend
on
specific
also
reviewed.
Finally,
conclusion
outlook
provide
insights
into
novel
blocks
development
enhanced
activities.
Язык: Английский
Self-Assembled Peptide-Based Fibrous Hydrogel as a Biological Catalytic Scaffold for Nitric Oxide Generation and Encapsulation
ACS Applied Materials & Interfaces,
Год журнала:
2025,
Номер
unknown
Опубликована: Апрель 29, 2025
Biomolecular
hydrogels
are
promising
scaffolds
for
biomedical
applications
ranging
from
controlled
drug
release
to
personalized
medicine.
However,
existing
macromolecular
nitric
oxide
(NO)
face
several
challenges,
such
as
a
low
payload
capacity,
rapid
release,
and
limited
biocompatibility.
Here,
we
present
the
design
of
short
peptide
derivatives
low-molecular-weight
gelators
that
spontaneously
self-assemble
into
nanofibrous
under
basic
aqueous
conditions.
Hydrogen
bonding
hydrophobic
interactions
central
driving
forces
assembly
process
contribute
tuning
mechanical
properties.
The
hydrogel
exhibits
secondary
structure
properties,
nanofibers
show
crystalline
behavior.
terminal
primary
amines
in
building
blocks
could
act
nucleophiles,
facilitating
endogenous
generation
NO
gas,
thus
making
scaffold
catalyst.
can
sequester
an
external
source
be
trapped
interstices
entangled
fibrous
networks.
Simultaneously,
it
demonstrates
anti-inflammatory
effects
activated
murine
macrophages.
This
designer
encapsulation
provides
fundamental
insights
biomaterials
applications.
Язык: Английский
Metal‐Organic Frameworks: A Potential Platform From Enzyme Immobilization to Mimetic Enzyme
Aggregate,
Год журнала:
2024,
Номер
unknown
Опубликована: Дек. 26, 2024
ABSTRACT
Metal‐organic
frameworks
(MOFs)
are
a
new
class
of
organic‐inorganic
hybrid
materials
that
have
been
widely
studied
in
the
past
two
decades
for
their
potential
catalysis.
(1)
In
this
review,
we
comprehensively
summarize
synthesis,
application,
and
advancements
MOFs
enzyme
immobilization
mimetic
enzymes.
(2)
We
also
discuss
design
principles
behind
various
MOF‐based
biocatalysts,
such
as
enzyme@MOF
composites,
explore
utility
reactions.
(3)
Additionally,
highlight
advantages
MOF
mimetics
provide
perspective
on
solutions
to
current
challenges
(4)
Ultimately,
review
provides
general
overview
most
recent
advances
catalyst
platforms,
including
biocatalysts
nanozymes,
applications.
Язык: Английский