Tuning the Near-Infrared J-Aggregate of a Multicationic Photosensitizer through Molecular Coassembly for Symbiotic Photothermal Therapy and Chemotherapy DOI
Zhenyan He, Yuting Gao, Zhen Huang

и другие.

ACS Nano, Год журнала: 2025, Номер unknown

Опубликована: Март 7, 2025

Cationic photosensitizers (PSs) offer many intriguing advantages, in addition to generating heat or reactive oxygen species for cancer phototherapy. However, the preparation of cationic PSs with enhanced near-infrared (NIR) absorption remains a significant challenge. In this work, we have synthesized PS TPBBT, which incorporates strong electron-withdrawing unit, benzobisthiadiazole, and four terminal pyridinium groups. It self-assembles into mixed H/J aggregated state maximal peak at 620 nm but coassembles negatively charged planar small molecules form sole J-aggregates. Following strategy, coassemble TPBBT rhein, planar, anionic traditional Chinese medicine an anticancer activity, allows near 100 bathochromic shift improves photothermal conversion efficiency (PCE) from 6.4 60.4% under 808 laser irradiation. Additionally, coassembling significantly enhances cellular uptake rhein through effect. The coassembly (TPBBTein) can completely eliminate 4T1 tumors on mouse models, validating that facile strategy not only tune NIR J-aggregate molecular also promotes efficient, symbiotic combination therapy chemotherapy.

Язык: Английский

Synthesis of phosphate-substituted near-infrared dyes for photoacoustic imaging and photothermal therapy DOI
Xinyi Ding, Yong Wang, Nan Jia

и другие.

Dyes and Pigments, Год журнала: 2025, Номер unknown, С. 112663 - 112663

Опубликована: Янв. 1, 2025

Язык: Английский

Процитировано

0
A cyanine fluorophore for imaging-guided tumor photodynamic and photothermal therapy under NIR-II light activation DOI
Wenkai Liu,

Chengyuan Lv,

Yanxian Hou

и другие.

Science China Chemistry, Год журнала: 2025, Номер unknown

Опубликована: Март 10, 2025

Язык: Английский

Процитировано

0
Development of small-molecule NIR-II photothermal agents for image-guided tumor therapy DOI
Long He, Yi Li,

Chonghua Zhang

и другие.

Coordination Chemistry Reviews, Год журнала: 2025, Номер 533, С. 216549 - 216549

Опубликована: Фев. 27, 2025

Язык: Английский

Процитировано

0
Nonlight-Driven Aggregation-Induced Emission Luminogens for Bioimaging and Theranostics DOI Creative Commons
Yong Tian,

Weigeng Huang,

Zhijia Sheng

и другие.

Chemical & Biomedical Imaging, Год журнала: 2025, Номер unknown

Опубликована: Март 4, 2025

Aggregation-induced emission luminogens (AIEgens) have been prosperously developed and applied in the fields of optical imaging theranostics since its establishment. Nowadays, AIEgens can fulfill nearly all requirements with spectra ranging from visible to near-infrared wavelengths. Although a variety varying wavelengths functionalities continuously designed, their performance is heavily dependent on use conventional light sources, such as xenon lamps lasers, which severely hinder further applications due limited penetration depth background autofluorescence biological tissues. To mitigate these limitations maximize potential AIEgens, unconventional excitation sources chemical energy, ultrasound, X-ray offer effective alternatives that circumvent drawbacks associated traditional light-based constant excitation. In this Review, we introduce fundamental principles governing combination highlight recent advancements using excited by for bioimaging theranostics, discuss current challenges future perspectives aimed at advancing biomedical AIEgens.

Язык: Английский

Процитировано

0
Tuning the Near-Infrared J-Aggregate of a Multicationic Photosensitizer through Molecular Coassembly for Symbiotic Photothermal Therapy and Chemotherapy DOI
Zhenyan He, Yuting Gao, Zhen Huang

и другие.

ACS Nano, Год журнала: 2025, Номер unknown

Опубликована: Март 7, 2025

Cationic photosensitizers (PSs) offer many intriguing advantages, in addition to generating heat or reactive oxygen species for cancer phototherapy. However, the preparation of cationic PSs with enhanced near-infrared (NIR) absorption remains a significant challenge. In this work, we have synthesized PS TPBBT, which incorporates strong electron-withdrawing unit, benzobisthiadiazole, and four terminal pyridinium groups. It self-assembles into mixed H/J aggregated state maximal peak at 620 nm but coassembles negatively charged planar small molecules form sole J-aggregates. Following strategy, coassemble TPBBT rhein, planar, anionic traditional Chinese medicine an anticancer activity, allows near 100 bathochromic shift improves photothermal conversion efficiency (PCE) from 6.4 60.4% under 808 laser irradiation. Additionally, coassembling significantly enhances cellular uptake rhein through effect. The coassembly (TPBBTein) can completely eliminate 4T1 tumors on mouse models, validating that facile strategy not only tune NIR J-aggregate molecular also promotes efficient, symbiotic combination therapy chemotherapy.

Язык: Английский

Процитировано

0