NIR‐II D–A–D‐Type Small‐Molecule Coordination with Carboxylatopillar[5]Arene: a Multifunctional Phototheranostic for Low‐Temperature NIR‐II Photothermal/Platinum‐Based/Chemodynamic Combination Cancer Immunotherapy DOI

Miaomiao Ding,

Hao Chen,

Liuliang He

и другие.

Small, Год журнала: 2025, Номер unknown

Опубликована: Апрель 21, 2025

Abstract Low‐temperature second near‐infrared region (NIR‐II) photothermal therapy (PTT) has shown significant potential in minimizing damage to normal tissues and reducing inflammation. However, it still faces challenge of insufficient immune response. Thus, a multifunctional phototheranostic nanoparticle (BDPB/Pt/Fe@P[5]) is developed by co‐loading BDPB, CDHPt, Fe 2 ⁺ with pH‐sensitive lipid DSPE‐PEOz2K. The carboxylatopillar[5]arene (CP[5]) used construct this exhibits strong host–guest recognition pyridine salts, alleviating aggregation caused quench (ACQ) effect enhancing the NIR‐II emission donor–acceptor–donor (D–A–D)‐type organic small molecule (BDPB). CP[5] provides suitable vehicles for encapsulating platinum (IV) prodrugs (CDHPt) ions via metal coordination controllable reactive oxygen species (ROS) release. Under low‐intensity laser irradiation an acidic tumor microenvironment, nanoparticles degrade, releasing CDHPt platinum‐based chemodynamic (CDT). facilitates direct production superoxide anions (O₂·⁻) from O₂ partially converts into highly cytotoxic hydroxyl radicals, thereby promoting Fenton reaction process. therapeutic efficacy further synergized immunogenic cell death (ICD) effect.

Язык: Английский

NIR‐II D–A–D‐Type Small‐Molecule Coordination with Carboxylatopillar[5]Arene: a Multifunctional Phototheranostic for Low‐Temperature NIR‐II Photothermal/Platinum‐Based/Chemodynamic Combination Cancer Immunotherapy DOI

Miaomiao Ding,

Hao Chen,

Liuliang He

и другие.

Small, Год журнала: 2025, Номер unknown

Опубликована: Апрель 21, 2025

Abstract Low‐temperature second near‐infrared region (NIR‐II) photothermal therapy (PTT) has shown significant potential in minimizing damage to normal tissues and reducing inflammation. However, it still faces challenge of insufficient immune response. Thus, a multifunctional phototheranostic nanoparticle (BDPB/Pt/Fe@P[5]) is developed by co‐loading BDPB, CDHPt, Fe 2 ⁺ with pH‐sensitive lipid DSPE‐PEOz2K. The carboxylatopillar[5]arene (CP[5]) used construct this exhibits strong host–guest recognition pyridine salts, alleviating aggregation caused quench (ACQ) effect enhancing the NIR‐II emission donor–acceptor–donor (D–A–D)‐type organic small molecule (BDPB). CP[5] provides suitable vehicles for encapsulating platinum (IV) prodrugs (CDHPt) ions via metal coordination controllable reactive oxygen species (ROS) release. Under low‐intensity laser irradiation an acidic tumor microenvironment, nanoparticles degrade, releasing CDHPt platinum‐based chemodynamic (CDT). facilitates direct production superoxide anions (O₂·⁻) from O₂ partially converts into highly cytotoxic hydroxyl radicals, thereby promoting Fenton reaction process. therapeutic efficacy further synergized immunogenic cell death (ICD) effect.

Язык: Английский

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