Electrostatic Co‐Assembly of Cyanine Pair for Augmented Photoacoustic Imaging and Photothermal Therapy
Advanced Science,
Год журнала:
2025,
Номер
unknown
Опубликована: Фев. 14, 2025
Abstract
Molecular
phototheranostic
dyes
are
of
eminent
interest
for
oncological
diagnosis
and
imaging‐guided
phototherapy.
However,
it
remains
challenging
to
develop
photosensitizers
(PSs)
that
simultaneously
integrate
high‐contrast
photoacoustic
imaging
efficient
therapeutic
capabilities.
In
this
work,
a
supramolecular
strategy
is
employed
construct
molecular
pair
agent
via
the
direct
self‐assembly
two
cyanines,
C5TNa
(anionic)
Cy‐Et
(cationic).
The
Coulombic
interactions
between
facilitate
formation
complementary
cyanine
(C5T‐ET)
creation
CT‐J‐type
aggregates
in
water.
This
results
completely
quenched
fluorescence
significantly
enhances
nonradiative
deactivation
(≈22
ps),
leading
3.3‐fold
increase
photothermal
conversion
efficiency
7.1‐fold
enhancement
response
compared
indocyanine
green
(ICG).
As
result,
J‐type
aggregate
demonstrates
high
capability
remarkable
antitumor
efficacy
vivo,
highlighting
its
potential
clinical
applications.
work
provides
strong
experimental
evidence
superior
performance
enhancing
photosensitization
response.
It
believed
will
propel
advancement
controllable
dye
J‐aggregates
contribute
practical
implementation
phototherapy
vivo.
Язык: Английский
Structure–Activity Relationship of Hemicyanine Molecules: Mitochondrion-Targeting Hemicyanine Fluorescent Molecular Probes for HSO3– Recognition and Near-Infrared Image-Guided Photothermal/Photodynamic Synergetic Therapy
The Journal of Physical Chemistry Letters,
Год журнала:
2025,
Номер
unknown, С. 1746 - 1752
Опубликована: Фев. 10, 2025
Hemicyanine
molecules
have
unparalleled
potential
in
the
fields
of
fluorescence
sensing,
bioimaging,
and
disease
therapeutics
due
to
their
excellent
optical
properties,
cell
penetration,
mitochondrial
targeting,
photosensitivity.
Herein,
three
dual-cation
hemicyanine
molecular
probes
named
DCy,
PDCy,
TDCy
were
developed.
All
them
could
detect
HSO3-,
PDCy
recognize
HSO3-
under
365
nm
ultraviolet
light
or
sunlight.
In
addition,
is
a
multifunctional
molecule,
which
has
following
advantages:
simple
synthesis,
red
near-infrared
dual-channel
imaging,
photothermal/photodynamic
synergistic
therapy
capabilities.
Upon
analysis
correlation
between
structures
recognition,
photosensitivity,
photothermal
activity,
cytotoxicity,
structure-activity
relationship
be
summarized,
provide
guidance
for
subsequent
research
development.
Язык: Английский
Tuning the Near-Infrared J-Aggregate of a Multicationic Photosensitizer through Molecular Coassembly for Symbiotic Photothermal Therapy and Chemotherapy
ACS Nano,
Год журнала:
2025,
Номер
unknown
Опубликована: Март 7, 2025
Cationic
photosensitizers
(PSs)
offer
many
intriguing
advantages,
in
addition
to
generating
heat
or
reactive
oxygen
species
for
cancer
phototherapy.
However,
the
preparation
of
cationic
PSs
with
enhanced
near-infrared
(NIR)
absorption
remains
a
significant
challenge.
In
this
work,
we
have
synthesized
PS
TPBBT,
which
incorporates
strong
electron-withdrawing
unit,
benzobisthiadiazole,
and
four
terminal
pyridinium
groups.
It
self-assembles
into
mixed
H/J
aggregated
state
maximal
peak
at
620
nm
but
coassembles
negatively
charged
planar
small
molecules
form
sole
J-aggregates.
Following
strategy,
coassemble
TPBBT
rhein,
planar,
anionic
traditional
Chinese
medicine
an
anticancer
activity,
allows
near
100
bathochromic
shift
improves
photothermal
conversion
efficiency
(PCE)
from
6.4
60.4%
under
808
laser
irradiation.
Additionally,
coassembling
significantly
enhances
cellular
uptake
rhein
through
effect.
The
coassembly
(TPBBTein)
can
completely
eliminate
4T1
tumors
on
mouse
models,
validating
that
facile
strategy
not
only
tune
NIR
J-aggregate
molecular
also
promotes
efficient,
symbiotic
combination
therapy
chemotherapy.
Язык: Английский
In-situ injectable hydrogel for near-infrared-regulated hyperthermic perfusion therapy of triple-negative breast cancer
Journal of Colloid and Interface Science,
Год журнала:
2025,
Номер
unknown
Опубликована: Март 1, 2025
Язык: Английский
Development of a Highly Efficient NIR-II Phototherapeutic Agent for Fluorescence Imaging-Guided Synergistic PTT/PDT/Chemotherapy of Colorectal Cancer
Journal of Medicinal Chemistry,
Год журнала:
2025,
Номер
unknown
Опубликована: Апрель 1, 2025
NIR-II-triggered
phototherapy
presents
a
noninvasive,
resistance-free
alternative
therapeutic
approach
with
deeper
tissue
penetration
and
improved
imaging
of
deep
tumors.
However,
many
NIR-II
phototherapeutic
agents
suffer
from
low
fluorescence
quantum
yields,
poor
photothermal
conversion
efficiency
(PCE),
reduced
efficacy
due
to
the
upregulation
heat
shock
protein
HSP70.
This
study
develops
small-molecule
agent
(IRF)
high
yield
(17.4%),
excellent
PCE
(96.8%)
for
therapy
(PTT),
photodynamic
(PDT)
activity.
To
decrease
thermal
resistance
during
phototherapy,
IRF
evodiamine
(EVO)
were
loaded
onto
hyaluronic
acid
(HA)-modified
nanoparticles,
creating
multifunctional
nanoplatform
termed
EVO/IRF@HA
NPs.
NPs
can
actively
target
tumors
via
HA
moiety.
Upon
980
nm
laser
irradiation,
increases
temperature
content
reactive
oxygen
species
synergistic
PTT/PDT.
Importantly,
EVO
effectively
inhibits
overexpression
HSP70,
enabling
combined
PTT/PDT/chemotherapy
effective
colorectal
cancer
(CRC)
treatment.
Язык: Английский