Novel capto-dative (Z,E)-2-(alkylthio)alk-2-en-4-ynals: synthesis and heterocyclization

Mendeleev Communications, Год журнала: 2021, Номер 31(6), С. 856 - 858

Опубликована: Ноя. 1, 2021

Язык: Английский

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An efficient and practical synthesis of functionalized pyridines via recyclable copper-catalyzed three-component tandem cyclization

Synthetic Communications, Год журнала: 2023, Номер 53(3), С. 205 - 216

Опубликована: Янв. 3, 2023

An efficient heterogeneous copper(I)-catalyzed three-component tandem cyclization of ketoxime acetates, aldehydes, and activated methylene compounds has been developed that proceeds smoothly in DMSO at 120 °C by using an 3-(2-aminoethylamino)propyl-modified MCM-41-bound copper(I) bromide [MCM-41-2N-CuBr] as the catalyst, delivering a variety polysubstituted pyridines good to high yields. The heterogenized catalyst can be readily obtained via simple preparative procedure from commercially available inexpensive reagents, reused more than seven times without any apparent drop its catalytic efficiency.

Язык: Английский

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Visible light-catalyzed intermolecular [2+2] cycloaddition of 1,2-dihydropyridines: A combined experimental and DFT study

Tetrahedron, Год журнала: 2023, Номер 136, С. 133357 - 133357

Опубликована: Март 17, 2023

Язык: Английский

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Metal‐Free Selective Synthesis of α,β‐Unsaturated Aldehydes from Alkenes and Formaldehyde Catalyzed by Dimethylamine

Chemistry - A European Journal, Год журнала: 2024, Номер 30(29)

Опубликована: Март 16, 2024

α,β-Unsaturated aldehydes are important building blocks for the synthesis of a wide range chemicals, including polymers. The these molecules from cheap feedstocks such as alkenes remains scientific challenge, mainly due to low reactivity alkenes. Here we report selective and metal-free access α,β-unsaturated with formaldehyde. This reaction is catalyzed by dimethylamine affords in yields up 80 %. By combining Density Functional Theory (DFT) calculations experiments, elucidate mechanism which based on cascade hydride transfer, hydrolysis aldolization reactions. can be performed under very mild conditions (30-50 °C), theoretically 100 % carbon-economical fashion, water only by-product. was successfully applied non-activated linear 1-alkenes, thus opening an industrially relevant widely abundant chemicals at large scale.

Язык: Английский

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Six-membered ring systems: pyridines and benzo derivatives

Progress in heterocyclic chemistry, Год журнала: 2021, Номер unknown, С. 397 - 430

Опубликована: Янв. 1, 2021

Язык: Английский

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