Synthesis of fused 3-trifluoromethyl-1,2,4-triazoles via base-promoted [3 + 2] cycloaddition of nitrile imines and 1H-benzo[d]imidazole-2-thiols
Organic & Biomolecular Chemistry,
Год журнала:
2023,
Номер
21(35), С. 7095 - 7099
Опубликована: Янв. 1, 2023
Here
we
report
a
strategy
for
the
facile
assembly
of
fused
3-trifluoromethyl-1,2,4-triazoles,
which
are
difficult
to
synthesize
using
traditional
strategies,
in
50-96%
yields
through
triethylamine-promoted
intermolecular
[3
+
2]
cycloaddition
pathway.
This
protocol
features
high
efficiency,
good
functional
group
tolerance,
mild
conditions,
and
easy
operation.
Furthermore,
gram-scale
reaction
product
derivatizations
were
carried
out
smoothly
illustrate
practicability
this
method.
Язык: Английский
Electrochemical Cyclization of Hydrazones and Amidines To Access Trisubstituted 1,2,4-Triazoles
Synlett,
Год журнала:
2023,
Номер
34(15), С. 1804 - 1808
Опубликована: Апрель 26, 2023
Abstract
A
KI-mediated
electrochemical
method
has
been
developed
for
the
synthesis
of
trisubstituted
1,2,4-triazoles
from
easily
accessible
hydrazones
and
amidines
derivatives.
The
protocol
provides
various
aryl
alkyl
in
moderate
to
good
yields
with
functional-group
tolerance
without
need
any
chemical
oxidants
an
undivided
cell.
Язык: Английский
Trifluoromethylated hydrazones and acylhydrazones as potent nitrogen-containing fluorinated building blocks
Beilstein Journal of Organic Chemistry,
Год журнала:
2023,
Номер
19, С. 1741 - 1754
Опубликована: Ноя. 15, 2023
Nitrogen-containing
organofluorine
derivatives,
which
are
prepared
using
fluorinated
building
blocks,
among
the
most
important
active
fragments
in
various
pharmaceutical
and
agrochemical
products.
This
review
focuses
on
reactivity,
synthesis,
applications
of
fluoromethylated
hydrazones
acylhydrazones.
It
summarizes
recent
methodologies
that
have
been
used
for
synthesis
nitrogen-containing
compounds.
Язык: Английский
Biological Evaluation of some Novel 1,3-Bis substituted-2-isopropylamidines by In-Silico Molecular Dynamics and Simulation Studies
New Journal of Chemistry,
Год журнала:
2024,
Номер
48(36), С. 15978 - 15988
Опубликована: Янв. 1, 2024
A
tandem
one-pot
synthesis
of
some
novel
1,3-bis
substituted-2-isopropylamidines
has
been
reported.
The
binding
affinities
the
purified
with
a
wide
range
protein
targets
is
assessed
using
molecular
docking
and
dynamics
simulations.
Язык: Английский
Trapping in situ generated CF3-nitrile imines with maleimides under solvent-free mechanochemical conditions
RSC Mechanochemistry,
Год журнала:
2024,
Номер
unknown
Опубликована: Янв. 1, 2024
A
series
of
trifluoromethylated
pyrrolo[3,4-
c
]pyrazoles
were
obtained
via
mechanochemical
(3
+
2)-cycloaddition
in
situ
generated
trifluoroacetonitrile
imines
with
maleimide
and
its
N
-aliphatic/aromatic
analogues.
Язык: Английский
ω-(3-Trifluoromethylpyrazol-4-yl)alkanoic acids via (3 + 2)-cycloaddition of nitrile imines with cyclic enones and deacylative aromatization
Journal of Fluorine Chemistry,
Год журнала:
2023,
Номер
272, С. 110206 - 110206
Опубликована: Окт. 19, 2023
Язык: Английский
Synthesis of 1,2,4‐Triazoles and 1,3,4‐Thiadiazinones by [3+2] and [3+3] Domino Annulation Reactions of Nitrile Imines with Succinimide and Thiazolidine‐2,4‐dione
Asian Journal of Organic Chemistry,
Год журнала:
2023,
Номер
12(4)
Опубликована: Март 10, 2023
Abstract
Herein;
we
report
protocols
for
the
synthesis
of
1,2,4‐triazoles
and
1,3,4‐
thiadiazinones
by
[3+2]
[3+3]
domino
annulation
reactions
nitrile
imines
with
succinimide
thiazolidine‐2,4‐dione,
respectively,
using
a
base
(1.5
equivalents)
alcohol
as
solvent.
In
these
reactions,
notably,
serves
not
only
solvent
but
also
reactant
participating
in
formation
ester
functionality
products.
These
methodologies
provide
metal‐free
direct
approaches
to
1,3,4‐thiadiazinones
under
mild
conditions
wide
substrate
scope
high
yields.
Язык: Английский