Iron(III) and BF₃·OEt₂-Promoted O-Transfer Reaction of N-Aryl-α,β-Unsaturated Nitrones to Prepare Difluoroboron β-Ketoiminates

Organic Letters, Год журнала: 2024, Номер 26(15), С. 3060 - 3064

Опубликована: Март 29, 2024

We described an iron(III) and BF3·OEt2-promoted oxygen transfer reaction of N-aryl-α,β-unsaturated nitrones to prepare various N,O-difluoroboron β-ketoiminates in good yields ranging from 24% 87%. Control experiments revealed that the enaminone was vital intermediate for formation β-ketoiminates, combined with BF3·OEt2 played as cocatalyst promote through intramolecular cyclization N–O bond cleavage. More importantly, estrone-derived β-ketoiminate easily prepared 40% yield estrone four steps.

Язык: Английский

Harnessing reductive BF2-complexation via Ru(II)-catalyzed N-O cleavage of isoxazoles

Chemical Communications, Год журнала: 2024, Номер 60(68), С. 9109 - 9112

Опубликована: Янв. 1, 2024

Developed here is a highly fluorescent organic N,O bidentate BF

Язык: Английский

Ruthenium(II)‐Catalyzed Selective C(sp²)−H Acyloxylation of 2‐Aroyl‐Pyridine Derivatives with Sodium Carboxylate

Advanced Synthesis & Catalysis, Год журнала: 2023, Номер 366(3), С. 518 - 525

Опубликована: Дек. 29, 2023

Abstract A ruthenium‐catalyzed C( sp 2 )−H acyloxylation of 2‐aroyl pyridine derivatives with simple sodium carboxylate utilizing transformable directing groups is described. This protocol features broad functional group tolerance and chemo‐ regio‐selectivity, providing the products in 45%‐84%yield. Furthermore, synthetic utility this was demonstrated by late‐stage functionalization pharmaceutical compounds. Notably, could be further transformed into a variety useful heterocycles under mild conditions.

Язык: Английский