Iron(III) and BF3·OEt2-Promoted O-Transfer Reaction of N-Aryl-α,β-Unsaturated Nitrones to Prepare Difluoroboron β-Ketoiminates
Xue Li,
Lin-Fen Liao,
Li‐Yao Ding
и другие.
Organic Letters,
Год журнала:
2024,
Номер
26(15), С. 3060 - 3064
Опубликована: Март 29, 2024
We
described
an
iron(III)
and
BF3·OEt2-promoted
oxygen
transfer
reaction
of
N-aryl-α,β-unsaturated
nitrones
to
prepare
various
N,O-difluoroboron
β-ketoiminates
in
good
yields
ranging
from
24%
87%.
Control
experiments
revealed
that
the
enaminone
was
vital
intermediate
for
formation
β-ketoiminates,
combined
with
BF3·OEt2
played
as
cocatalyst
promote
through
intramolecular
cyclization
N–O
bond
cleavage.
More
importantly,
estrone-derived
β-ketoiminate
easily
prepared
40%
yield
estrone
four
steps.
Язык: Английский
Harnessing reductive BF2-complexation via Ru(II)-catalyzed N-O cleavage of isoxazoles
Chemical Communications,
Год журнала:
2024,
Номер
60(68), С. 9109 - 9112
Опубликована: Янв. 1, 2024
Developed
here
is
a
highly
fluorescent
organic
N,O
bidentate
BF
Язык: Английский
Ruthenium(II)‐Catalyzed Selective C(sp2)−H Acyloxylation of 2‐Aroyl‐Pyridine Derivatives with Sodium Carboxylate
Advanced Synthesis & Catalysis,
Год журнала:
2023,
Номер
366(3), С. 518 - 525
Опубликована: Дек. 29, 2023
Abstract
A
ruthenium‐catalyzed
C(
sp
2
)−H
acyloxylation
of
2‐aroyl
pyridine
derivatives
with
simple
sodium
carboxylate
utilizing
transformable
directing
groups
is
described.
This
protocol
features
broad
functional
group
tolerance
and
chemo‐
regio‐selectivity,
providing
the
products
in
45%‐84%yield.
Furthermore,
synthetic
utility
this
was
demonstrated
by
late‐stage
functionalization
pharmaceutical
compounds.
Notably,
could
be
further
transformed
into
a
variety
useful
heterocycles
under
mild
conditions.
Язык: Английский