Comprehensive Strategies for the Synthesis of 1,3-Enyne Derivatives

Synthesis, Год журнала: 2024, Номер unknown

Опубликована: Май 1, 2024

Abstract The synthesis of 1,3-enyne has widespread appeal in organic due to their proven adaptability as intermediates routes compounds significant biological and material interest. A variety methods have been designed formulate 1,3-enynes from diverse substrates, such alkynes, 1,3-diynes, alkynyl-substituted cyclopropanes, propargyl alcohols. This review covers the utilizing homo- cross-coupling nucleophilic metal/acid-induced cyclopropane ring opening, rearrangement/dehydration key concern procedures starting alkynes 1,3-diynes is management regio-, stereo-, and, where fitting, chemoselectivity. In contrast, cyclopropyl opening nucleophile orientation determines formed. Efficient for broad selective are highlighted specific examples given demonstrate efficacy these processes. 1 Introduction Scope 2 Synthesis 2.1 1,3-Enynes Alkynes 2.1.1 Metal-Catalyzed Cross-Coupling/Additions with Alkenes or Vinyl Aryl Halides 2.1.1.1 Palladium Catalysis 2.1.1.2 Rhodium 2.1.1.3 Copper 2.1.1.4 I ron 2.1.1.5 Nickel 2.1.1.6 Miscellaneous 2.2 Enynes Propargyl Alcohols 2.3 Metal/Acid-Catalyzed Ring Opening Cyclopropanes 3 Conclusion

Язык: Английский

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Synthesis and Characterization of Novel Pd@rGO−CuFe₂O₄ Magnetic Nanoparticles: A Recyclable Catalyst for C−C Coupling Reaction in Biomass‐Derived Organic Solvent

Asian Journal of Organic Chemistry, Год журнала: 2023, Номер 12(12)

Опубликована: Окт. 6, 2023

Abstract Development of new, cost effective, stable heterogeneous catalyst for the organic transformations is an important thematic area research. Present work describes development new Pd@rGO−CuFe 2 O 4 and demonstrates its effectiveness Suzuki‐Miyaura type coupling reactions. The additional advantage this reaction feasibility using biomass‐derived solvent like γ‐Valerolactone (GVL) in aqueous media. prepared hydrothermally characterized XRD, FESEM, EDX, XPS analysis. exhibits excellent activity recyclability (up to six times) C−C deliver corresponding biaryl molecules yields up 90 %. High efficiency conversion nitriles amides also revealed by catalyst.

Язык: Английский

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The γ-Valerolactone (GVL) as Innoxious Reaction Media for the Synthesis of 2-Aryl-2H-Indazoles via C-N and N-N Bond Formation under Cu(I)-Catalyzed Ligand and Base Free Conditions

Polycyclic aromatic compounds, Год журнала: 2023, Номер 44(7), С. 4832 - 4843

Опубликована: Сен. 13, 2023

AbstractAn efficient method for N-arylation and N-N bond formation has been developed using an innoxious reaction medium, γ-valerolactone (GVL), as both a solvent ligand. The strategy involves utilizing CuI catalyst under conditions free of external ligands bases. Various aldehyde amine derivatives with different functional groups were investigated, resulting in the production 2-aryl-2H-indazole compounds yields ranging from 75% to 93%. This study highlights effectiveness GVL, derived biomass, medium ligand multicomponent reaction.Keywords: C-N formationN-N formationCu(I)-catalysis2H-indazolemulticomponent AcknowledgementsCCM appreciates Science Engineering Research Board (SERB), New Delhi financial support form research grants [CRG/2020/004509 ECR/2016/000337]. KK grateful Ministry Education (MoE), fellowship support. authors extend their appreciation Researchers Supporting Project number [RSP2023R381], King Saud University, Riyadh, Saudi Arabia.Author contributionsThe manuscript was written through contributions all have given approval final version manuscript.Disclosure statementNo potential conflict interest reported by author(s).

Язык: Английский

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Metal- and Hazardous Reagent-Free Transamidation Process: the NH₂OH⦁HCl Promoted N-Formylation and N-Acylation Reaction under Solvent-Less Conditions

Polycyclic aromatic compounds, Год журнала: 2023, Номер 44(7), С. 4746 - 4758

Опубликована: Сен. 14, 2023

AbstractAn efficient transamidation process has been described under solvent-less conditions. The transformation accomplished by employing NH2OH⦁HCl as a reagent and amines substrates. developed method is achieved in the absence of metals hazardous reagents. A series were explored to obtain N-formylation N-acylation reactions with excellent yields (81-96%) products. DFT analysis was also performed, which provides clear understanding process. postulated mechanism well supported control experiments.Keywords: TransamidationC-N bond formationamidesNH2OH⦁HCl reagentDFT AcknowledgementsCCM appreciates Science Engineering Research Board (SERB), New Delhi for financial supports form research grants (CRG/2020/004509 ECR/2016/000337). KK DK are grateful Ministry Education (MoE), fellowship supports. authors extend their appreciation Researchers Supporting Project number (RSP2023R396), King Saud University, Riyadh, Saudi Arabia.Disclosure statementNo potential conflict interest reported author(s).Author contributionsThe manuscript written through contributions all have given approval final version manuscript.

Язык: Английский

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Direct C-H functionalisation of azoles via Minisci reactions

Organic & Biomolecular Chemistry, Год журнала: 2024, Номер unknown

Опубликована: Янв. 1, 2024

This review gives an overview of the C–H functionalisation azoles via Minisci-type reactions, highlighting recent progress, existing limitations and potential areas for growth.

Язык: Английский

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