Abstract
Organophosphorus
compounds
have
been
widely
used
as
achiral
and
chiral
ligands
in
organic
synthesis
(PPh
3
,
BINAP,
dppe,
Duphos,
Xantphos,
PPFA,
Chiraphos,
SEGPHOS),
flame
retardants,
functional
materials
(LED,
PV),
well
agrochemicals
medicines
due
to
their
broad
biological
activities.
As
the
privileged
versatile
building
blocks,
1,n‐enynes
successfully
applied
of
various
functionalized
cyclic
based
on
two
active
unsaturated
chemical
bonds
(C═C
double
C≡C
triple
bonds).
With
development
highly
selective
efficient
methods
chemistry,
organophosphorus
through
radical
cascade
strategy
has
attracted
considerable
attention
recent
years.
In
here,
we
summarized
main
achievements
reactions
with
phosphorus‐centered
radicals.
Furthermore,
also
displayed
detailed
reaction
mechanisms
this
review.
A
Cu-catalyzed
relay
process
for
the
preparation
of
diazidated
quinazolinone
and
polycyclic
imidazole
derivatives
in
which
readily
available
alkene-tethered
substrates
undergo
an
addition/cyclization/C(sp3)–H
functionalization
alkene
sequences
with
high
efficiency
is
described.
Various
functionalized
N-heteropolycyclic
compounds
were
prepared
good
yields
a
broad
substrate
scope.
Moreover,
direct
azidation
α-C(sp3)–H
bond
corresponding
N-heterocycles
has
been
demonstrated
on
basis
mechanistic
studies,
provide
alternative
late-stage
approach
derivatization
N-heterocyclic
scaffolds.
Chemical Communications,
Год журнала:
2024,
Номер
60(18), С. 2556 - 2559
Опубликована: Янв. 1, 2024
3-(2-Isocyanophenyl)quinazolin-4(3
H
)-ones
were
designed
and
synthesized
as
new
building
units
for
the
construction
of
novel
quinoxalino[2,1-
b
]quinazolinones
under
mild,
photocatalytic
metal-free
conditions.
Chemical Communications,
Год журнала:
2024,
Номер
60(35), С. 4687 - 4690
Опубликована: Янв. 1, 2024
A
visible-light-induced
carbophosphorylation/cyclization
of
N
-homoallyl
and
-allyl
aldehyde
hydrazones
with
phosphine
oxides
was
developed
to
obtain
phosphorylated
tetrahydropyridazines
dihydropyrazoles.
ACS Omega,
Год журнала:
2024,
Номер
9(26), С. 28129 - 28143
Опубликована: Июнь 19, 2024
An
efficient
and
mild
protocol
for
the
visible
light-induced
radical
cascade
difluoromethylation/cyclization
of
imidazoles
with
unactivated
alkenes
using
easily
accessible
bench-stable
difluoromethyltriphenylphosphonium
bromide
as
precursor
-CF
The Journal of Organic Chemistry,
Год журнала:
2024,
Номер
89(4), С. 2718 - 2725
Опубликована: Фев. 2, 2024
An
anodically
oxidizing
trifluoromethylation
cascade
of
N-cyanamide
alkene
bearing
two
electronically
differentiated
olefin
moieties
was
reported,
in
which
various
N-unsaturated
acyl
cyanamide
alkenes
and
CF3SO2Na
acting
as
readily
available
starting
materials
furnished
nonaromatic
fused
azaheterobicyclic
compounds
a
highly
efficient
sustainable
manner.
The
broad
substrate
scope,
facile
scalability,
sustainability
enabled
this
electrochemical
process
to
be
an
appealing
complement
for
trifluoromethylated
cyclic
amidines.
Chemical Communications,
Год журнала:
2024,
Номер
60(56), С. 7228 - 7231
Опубликована: Янв. 1, 2024
A
visible-light-induced
K
2
S
O
8
-promoted
cascade
sulfonation/cyclization
reaction
to
afford
a
series
of
sulfonated
quinolino[2,1-
b
]quinazolinones
has
been
developed
under
mild
conditions.
Organic & Biomolecular Chemistry,
Год журнала:
2023,
Номер
21(35), С. 7079 - 7084
Опубликована: Янв. 1, 2023
Polychloromethylative
cyclization
of
N-alkenyl
indoles
was
developed
under
metal-free
conditions
to
afford
tricyclic
pyridoindolones
and
pyrroloindolones
in
moderate
good
yields.
In
the
reaction,
commercially
available
CHCl3
CH2Cl2
were
employed
as
tri-
dichloromethyl
radical
sources.
Moreover,
dichloromethylated
polycyclic
benzoimidazoles
can
also
be
obtained
standard
conditions.
RSC Advances,
Год журнала:
2025,
Номер
15(16), С. 12739 - 12745
Опубликована: Янв. 1, 2025
A
mild
and
effective
visible-light-induced
decarboxylative
radical
cascade
reaction
of
olefin-containing
imidazoles
α-fluorinated
carboxylic
acids,
has
been
developed
to
afford
monofluoromethylated
or
aryldifluoromethylated
polycyclic
imidazoles.
European Journal of Organic Chemistry,
Год журнала:
2023,
Номер
26(31)
Опубликована: Июнь 15, 2023
Abstract
A
visible‐light
induced
radical
1,2‐aryl
migration
of
α,α‐diarylallyl
alcohols
was
developed
under
mild
and
metal‐free
conditions.
Commercially
available
CHCl
3
CH
2
Cl
were
used
as
tri‐
dichloromethyl
precursors.
Structurally
diverse
β‐polochloromethylated
ketones
obtained
in
good
to
moderate
yields
via
neophyl‐type
rearrangement.
Besides,
the
polychloromethyl
group
can
be
easily
transformed
into
other
useful
functional
groups.
The Journal of Organic Chemistry,
Год журнала:
2024,
Номер
89(11), С. 7770 - 7779
Опубликована: Май 13, 2024
A
visible-light-enabled
photoredox
radical
cascade
cyclization
of
2-vinyl
benzimidazole
derivatives
is
developed.
This
chemistry
applicable
to
a
wide
range
