Discovery of Crinasiadine, Trisphaeridine, Bicolorine, and Their Derivatives as Anti-Tobacco Mosaic Virus (TMV) Agents

International Journal of Molecular Sciences, Год журнала: 2025, Номер 26(3), С. 1103 - 1103

Опубликована: Янв. 27, 2025

Plant viral diseases cause great harm to crops in terms of yield and quality. Natural products have been providing an excellent source novel chemistry, inspiring the development synthetic pesticides. The Amaryllidaceae alkaloids crinasiadine (3a), trisphaeridine (4a), bicolorine (5a) were selected as parent structures, a series their derivatives designed, synthesized, investigated for anti-plant virus effects first time. Compounds 13b 18 exhibited comparable inhibitory activities ningnanmycin against tobacco mosaic (TMV). Preliminary research into mechanism, involving transmission electron microscopy molecular docking studies, suggests that compound may interfere with elongation phase TMV assembly process. This study provides some important information agrochemicals phenanthridine structures.

Язык: Английский

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Visible-Light-Induced Glycosylation/Annulation of 2-Isocyanobiaryls and Glycosyl NHP Esters to Access Nonclassical Heteroaryl C-Glycosides

The Journal of Organic Chemistry, Год журнала: 2025, Номер unknown

Опубликована: Янв. 13, 2025

A photoredox-promoted cascade glycosylation/cyclization reaction of 2-isocyanobiaryls and glycosyl NHP esters was established for the synthesis nonclassical heteroaryl C-glycosides. This methodology is characterized by an exceedingly simple system, high diastereoselectivity, good functional group tolerance. In contrast to traditional strategies, this innovative approach circumvents need temperature, transition metal, photocatalyst, offering environmentally friendly efficient protocol.

Язык: Английский

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Visible-light-induced radical cascade cyclization of 2-isocyanobiaryls via 1,5-hydrogen atom transfer (1,5-HAT)

Organic Chemistry Frontiers, Год журнала: 2025, Номер unknown

Опубликована: Янв. 1, 2025

We reported the first example of visible-light-induced radical cascade cyclization 2-isocyanobiaryls via 1,5-HAT, which is characterized by broad substrate scope, excellent functional group compatibility and no requirement any metals base.

Язык: Английский

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Photochemical Decarboxylative Radical Alkylation/Cyclization Reaction to Fused Nitrogen Heterocycles by LiI/PPh₃ Catalysis

Chinese Journal of Chemistry, Год журнала: 2024, Номер unknown

Опубликована: Сен. 10, 2024

Comprehensive Summary A visible‐light‐induced decarboxylative radical cascade cyclization reaction between N ‐(2‐cyanoaryl)‐acrylamides and alkyl ‐(acyloxy)phthalimide (NHPI esters) for the construction of phenanthridine derivatives has been developed. This approach utilizes lithium iodide (LiI) triphenylphosphine (PPh 3 ) as redox catalysts is produced through photoactivation electron donor‐acceptor (EDA) complex. series primary, secondary, tertiary alkyl‐substituted phenanthridines are prepared in up to 82% yield without transition‐metal catalysts, chemical oxidants, or metal‐/organic dye‐based photocatalysts.

Язык: Английский

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Transition-Metal Free Approaches to Access N-Heterocycles and Valuable Intermediates from Aryldiazonium Salts

Organic Chemistry Frontiers, Год журнала: 2024, Номер unknown

Опубликована: Ноя. 13, 2024

Development of novel and efficient synthetic methods to achieve valuable N-heterocycles from aryldiazonium salts has been an important research area in organic chemistry for several decades.

Язык: Английский

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Trifunctionalization of C=C Bonds in Vinyl Azides to Access Densely Functionalized Phenanthridines Enabled by the NCS/AgNO2 System

Organic & Biomolecular Chemistry, Год журнала: 2024, Номер 22(29), С. 5982 - 5986

Опубликована: Янв. 1, 2024

An unprecedented trifunctionalization of CC bonds in 2-(1-azidovinyl)-1,1'-biphenyls has been successfully achieved using the NCS/AgNO

Язык: Английский

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1,1′-Diarylethylene as a Key Additive for the Visible Light Synthesis of Bioactive Dihydrobenzo[a]phenanthridine Compounds

The Journal of Organic Chemistry, Год журнала: 2024, Номер 89(20), С. 15117 - 15136

Опубликована: Окт. 1, 2024

This study introduces a straightforward synthetic approach for generating 7,8-dihydrobenzo[

Язык: Английский

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Visible-light-induced radical difluoromethylation/cyclization of biarylvinyl azides: facile access to CF2H-labelled phenanthridines

Journal of Fluorine Chemistry, Год журнала: 2024, Номер unknown, С. 110372 - 110372

Опубликована: Ноя. 1, 2024

Язык: Английский

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