Hybrid Metal Catalysts as Valuable Tools in Organic Synthesis: An Overview of the Recent Advances in Asymmetric C─C Bond Formation Reactions DOI Creative Commons
Isabella Rimoldi, Giulia Coffetti, Raffaella Gandolfi

и другие.

Molecules, Год журнала: 2024, Номер 29(21), С. 5090 - 5090

Опубликована: Окт. 28, 2024

Carbon–carbon bond formation represents a key reaction in organic synthesis, resulting paramount importance for constructing the carbon backbone of molecules. However, traditional metal-based catalysis, despite its advantages, often struggles with issues related to efficiency, selectivity, and sustainability. On other hand, while biocatalysis offers superior selectivity due an extraordinary recognition process substrate, scope applicable reactions remains somewhat limited. In this context, Artificial Metalloenzymes (ArMs) Metallo Peptides (MPs) offer promising not fully explored solution, merging two fields transition metal catalysis biotransformations, by inserting catalytically active cofactor into customizable protein scaffold or coordinating ion directly short tunable amino acid (Aa) sequence, respectively. As result, these hybrid catalysts have gained attention as valuable tools challenging catalytic transformations, providing systems new-to-nature properties synthesis. This review overview recent advances development ArMs MPs, focusing on their application asymmetric carbon–carbon bond-forming reactions, such carbene insertion, Michael additions, Friedel–Crafts cross-coupling cyclopropanation, underscoring versatility synthesizing biologically relevant compounds.

Язык: Английский

Regio- and chemoselective synthesis of flavanone isosteres via multicomponent reactions: synergistic role of hydrogen bonding and solvent effects DOI
Lixin Zhang,

Ziyi Tang,

Xinyue Liu

и другие.

Molecular Diversity, Год журнала: 2025, Номер unknown

Опубликована: Март 26, 2025

Язык: Английский

Процитировано

0
Sustainable Synthesis of Novel Tris‐thio/Semicarbazones and Tris‐rhodanines with Antiproliferative and Wastewater Treatment Applications DOI
Wael A. A. Arafa, AbdElAziz A. Nayl, Modather F. Hussein

и другие.

ChemistrySelect, Год журнала: 2025, Номер 10(19)

Опубликована: Май 1, 2025

Abstract A new series of tris‐rhodanines ( 3 ) and tris‐thio/semicarbazones 5 have been designed, sono‐synthesized, characterized employing diverse spectral methods. Additionally, the copper complex 6 derived from tris‐thiosemicarbazone ligand 5b successfully photodegraded methylene blue (MB) showed superior effectiveness (97%), suggesting its potential for utilization in wastewater treatment systems. Furthermore, antiproliferative activities designed compounds evaluated regarding MCF‐7, A549 (cancer cell lines), MCF‐10A (normal lines). The results indicated that developed demonstrated promising inhibitory impacts (IC 50 = 1.27–11.57 µM), even outperforming doxorubicin certain cases. exhibited noteworthy anticancer properties <1.30 µM) a less cytotoxic influence on normal line 85.07 as leading candidate cancer‐preventing medicaments. structure‐activity relationship assessment revealed hydrogen donor motifs, like carboxyl linked to rhodanine or terminal benzyl moiety connected tris‐thiosemicarbazones, are more effective activities. density functional theory (DFT)‐based quantum chemical analysis assembled molecules has found be agreement with vitro inhibiting activity. Lastly, docking evaluation all efficiently interacted targeted proteins' active sites (4AOR 6JZ0) had low binding energies, particularly 5c (−8.35, −7.64 kcal/mol) (−7.59, −7.03 kcal/mol).

Язык: Английский

Процитировано

0
Hybrid Metal Catalysts as Valuable Tools in Organic Synthesis: An Overview of the Recent Advances in Asymmetric C─C Bond Formation Reactions DOI Creative Commons
Isabella Rimoldi, Giulia Coffetti, Raffaella Gandolfi

и другие.

Molecules, Год журнала: 2024, Номер 29(21), С. 5090 - 5090

Опубликована: Окт. 28, 2024

Carbon–carbon bond formation represents a key reaction in organic synthesis, resulting paramount importance for constructing the carbon backbone of molecules. However, traditional metal-based catalysis, despite its advantages, often struggles with issues related to efficiency, selectivity, and sustainability. On other hand, while biocatalysis offers superior selectivity due an extraordinary recognition process substrate, scope applicable reactions remains somewhat limited. In this context, Artificial Metalloenzymes (ArMs) Metallo Peptides (MPs) offer promising not fully explored solution, merging two fields transition metal catalysis biotransformations, by inserting catalytically active cofactor into customizable protein scaffold or coordinating ion directly short tunable amino acid (Aa) sequence, respectively. As result, these hybrid catalysts have gained attention as valuable tools challenging catalytic transformations, providing systems new-to-nature properties synthesis. This review overview recent advances development ArMs MPs, focusing on their application asymmetric carbon–carbon bond-forming reactions, such carbene insertion, Michael additions, Friedel–Crafts cross-coupling cyclopropanation, underscoring versatility synthesizing biologically relevant compounds.

Язык: Английский

Процитировано

0