Catalysts, Год журнала: 2025, Номер 15(5), С. 482 - 482
Опубликована: Май 15, 2025
Tetrasubstituted furans and their derivatives represent a versatile class of important heterocyclic frameworks widely distributed in natural products. These scaffolds also demonstrate significant potential pharmaceutical chemistry, materials science, organic synthesis methodologies. In this study, we successfully established synergistic catalytic system utilizing benzoylacetonitriles, aldehydes, benzoyl chlorides as substrates, facilitated by tributylphosphine immobilized lipase (Novozym 435), to achieve efficient cyano-containing tetrasubstituted furans. Under optimized conditions, obtained series target products exhibiting exceptional substrate tolerance with good excellent isolated yields ranging from 80% 94%. Additionally, proposed reasonable reaction mechanism verified it through controlled experiments. This methodology not only expands the synthetic utility non-natural transformations but establishes paradigm green chemistry for construction
Язык: Английский