Dearomative Amination Cyclization of Tryptamines and Tryptophols via Enantioselective 1,6‐Addition of p‐Quinone Diimides (p‐QDIs) DOI

Parbat Subba,

Chhavi Khajuria,

Vinod K. Singh

и другие.

Asian Journal of Organic Chemistry, Год журнала: 2025, Номер unknown

Опубликована: Май 21, 2025

Abstract A method utilizing p ‐quinone diimides ( ‐QDIs) as electrophilic nitrogen source to facilitate a highly enantioselective dearomative cyclization of tryptamine and tryptophol derivatives has been developed. This approach which proceeds via 1,6‐addition ‐QDIs enables the rapid efficient synthesis chiral 3‐amino‐pyrroloindoline 3‐amino‐furoindolines with excellent stereochemical control (up 99%). Development an alternate one‐pot method, coupled some synthetic transformations further elevates practical utility this strategy.

Язык: Английский

Dearomative Amination Cyclization of Tryptamines and Tryptophols via Enantioselective 1,6‐Addition of p‐Quinone Diimides (p‐QDIs) DOI

Parbat Subba,

Chhavi Khajuria,

Vinod K. Singh

и другие.

Asian Journal of Organic Chemistry, Год журнала: 2025, Номер unknown

Опубликована: Май 21, 2025

Abstract A method utilizing p ‐quinone diimides ( ‐QDIs) as electrophilic nitrogen source to facilitate a highly enantioselective dearomative cyclization of tryptamine and tryptophol derivatives has been developed. This approach which proceeds via 1,6‐addition ‐QDIs enables the rapid efficient synthesis chiral 3‐amino‐pyrroloindoline 3‐amino‐furoindolines with excellent stereochemical control (up 99%). Development an alternate one‐pot method, coupled some synthetic transformations further elevates practical utility this strategy.

Язык: Английский

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