AJPM Focus, Год журнала: 2025, Номер 4(3), С. 100324 - 100324
Опубликована: Фев. 17, 2025
Язык: Английский
Archives of Clinical Neuropsychology, Год журнала: 2024, Номер 39(6), С. 732 - 746
Опубликована: Фев. 13, 2024
Cognitive dispersion indexes intraindividual variability in performance across a battery of neuropsychological tests. Measures show promise as markers cognitive dyscontrol and everyday functioning difficulties; however, they have limited practical applicability due to lack normative data. This study aimed develop evaluate normed scores for among older adults.
Язык: Английский
Процитировано
8
Alzheimer s & Dementia, Год журнала: 2024, Номер 20(7), С. 4828 - 4840
Опубликована: Июнь 5, 2024
Leveraging the nonmonolithic structure of Latin America, which represents a large variability in social determinants health (SDoH) and high levels genetic admixture, we aim to evaluate relative contributions SDoH ancestry predicting dementia prevalence American populations.
Язык: Английский
Процитировано
8
Current Sleep Medicine Reports, Год журнала: 2025, Номер 11(1)
Опубликована: Янв. 3, 2025
Язык: Английский
Процитировано
1
Alzheimer s & Dementia Translational Research & Clinical Interventions, Год журнала: 2025, Номер 11(1)
Опубликована: Янв. 1, 2025
Abstract INTRODUCTION Recruitment of participants for intervention studies is challenging. We evaluated the effectiveness and efficiency a participant recruitment campaign through an online registry FINGER‐NL study, multi‐domain lifestyle trial targeting cognitively healthy individuals aged 60–79 with dementia prevention potential. Additionally, we explored which strategy successfully reached from underrepresented groups in research. METHODS The entailed seven strategies referring to Dutch Brain Research Registry (DBRR): (1) Facebook advertisements, (2) appearance on national television, (3) newspaper articles, (4) researcher outreach, (5) patient organizations, (6) search engines, (7) other. For each strategy, describe number (a) registered, (b) potentially eligible, (c) included FINGER‐NL. Subsequently, efficiency, defined by eligibility ratio (eligible/registered), effectiveness, inclusion (included/registered) were calculated. Associations between sociodemographic factors tested binomial logistic regressions. RESULTS resulted 13,795 new DBRR registrants, n = 3475 eligible (eligibility 0.25) 1008 (inclusion 0.07). advertisements television highest numbers registrants ( 4678 2182) translated inclusions 288 262). 0.35), articles (0.26), campaigns (0.26) most efficient strategies. 0.13) was effective strategy. performed relatively better recruiting groups. DISCUSSION A multipronged via prescreening adequate years potential multi‐site within limited time frame 15 months. Social media are preferred recruit Highlights An brain research recruited successfully. Mass reaching large numbers. Direct researchers organizations seems more effective. Online registries offer automated alternatives screen‐failures. Tailored needed reach improve diversity.
Язык: Английский
Процитировано
1
JAMA Otolaryngology–Head & Neck Surgery, Год журнала: 2025, Номер unknown
Опубликована: Апрель 17, 2025
Importance Hearing loss treatment delays cognitive decline in high-risk older adults. The preventive potential of addressing hearing on incident dementia a community-based population adults, and whether it varies by method measurement, is unknown. Objective To calculate the attributable fraction associated with adults to investigate differences age, sex, self-reported race, measurement. Design, Setting, Participants This prospective cohort study was part Atherosclerosis Risk Communities Neurocognitive Study (ARIC-NCS) had up 8 years follow-up (2011-2019). 4 ARIC field centers included Jackson, Mississippi; Forsyth County, North Carolina; Minneapolis suburbs, Minnesota; Washington Maryland. Community-dwelling aged 66 90 without at baseline who underwent assessment ARIC-NCS visit 6 (2016-2017) were analysis. Data analysis took place between June 2022 July 2024. Exposures measured objectively (audiometric) subjectively (self-reported). Main Outcomes Measures main outcome (standardized algorithmic diagnosis expert panel review). fractions from both audiometric calculated same participants, which quantified maximum proportion risk that can be attributed loss. Results Among 2946 participants (mean [SD] 74.9 [4.6] years; 1751 [59.4] female; 637 Black [21.6%] 2309 White [78.4%] individuals), 1947 (66.1%) loss, 1097 (37.2%) any 32.0% (95% CI, 11.0%-46.5%). Population similar severity (mild HL: 16.2% [95% 4.2%-24.2%]; moderate or greater 16.6% 3.9%-24.3%]). Self-reported not an increased for dementia, so quantifiable. larger among those 75 (30.5% −5.8% 53.1%]), female (30.8% 5.9%-47.1%]), (27.8% −6.0% 49.8%]), relative younger than years, male, Black. Conclusions Relevance suggests treating might delay large number Public health interventions targeting clinically significant have broad benefits prevention. Future research quantifying should carefully consider measures are used define as self-reporting may underestimate hearing-associated risk.
Язык: Английский
Процитировано
1
Alzheimer s & Dementia, Год журнала: 2024, Номер 20(3), С. 2273 - 2281
Опубликована: Янв. 29, 2024
The Harmonized Cognitive Assessment Protocol (HCAP) is a major innovation that provides, for the first time, harmonized data cross-national comparisons of later-life cognitive functions are sensitive to linguistic, cultural, and educational differences across countries. However, function does not lend itself direct comparison diverse populations without careful consideration best practices such comparisons. This perspective discusses theoretical methodological considerations offers set recommended conducting risk factor associations using HCAP data. Because existing planned studies provide cognition representing an estimated 75% global population ≥65 years age, these will support high-quality comparative analyses aging around world. principles described in this applicable any researcher aiming integrate or compare on outcomes their protective factors populations.
Язык: Английский
Процитировано
6
The Lancet Public Health, Год журнала: 2024, Номер 9(4), С. e240 - e249
Опубликована: Март 27, 2024
BackgroundCognitive decline in people experiencing homelessness is an increasingly recognised issue. We compared the prevalence of dementia among to housed individuals general population and those living low-income neighbourhoods.MethodsWe conducted a population-based, cross-sectional, comparative analysis using linked health-care administrative data from Ontario, Canada. included aged 45 years or older on Jan 1, 2019, who visited hospital-based ambulatory care (eg, emergency department), were hospitalised, community health centre 2019; identified if they had one more records with indication unstable housing. Prevalence was ascertained as Dec 31, validated case definition for Alzheimer's disease related that modified include diagnoses made at centre. Poisson models used generate estimates prevalence. Estimates Ontarians accessed any same services over time, overall (general group), lowest quintile area-based neighbourhood income (low-income group).Findings12 863 homelessness, 475 544 comparator group, 2 273 068 group study. Dementia 68·7 per 1000 62·6 51·0 group. Descriptively, ratios between groups highest within ages 55–64 65–74 both sexes, ranging 2·98 5·00. After adjusting age, sex, geographical location residence (urban vs rural), conditions associated dementia, ratio 1·71 (95% CI 1·60–1·82) 1·90 (1·79–2·03) group.InterpretationPeople experience high burden populations Ontario. Findings suggest might younger could benefit development proactive screening housing interventions.FundingThe Public Health Agency
Язык: Английский
Процитировано
6
bioRxiv (Cold Spring Harbor Laboratory), Год журнала: 2024, Номер unknown
Опубликована: Апрель 20, 2024
Abstract INTRODUCTION Multi-omics studies in Alzheimer’s disease (AD) revealed many potential pathways and therapeutic targets. Despite their promise of precision medicine, these lacked African Americans (AA) Latin (LA), who are disproportionately affected by AD. METHODS To bridge this gap, Accelerating Medicines Partnership AD (AMP-AD) expanded brain multi-omics profiling to multi-ethnic donors. RESULTS We generated data curated harmonized phenotypic from AA (n=306), LA (n=326), or (n=4) donors plus Non-Hispanic White (n=252) other (n=20) ethnic groups, establish a foundational dataset enriched for participants. This study describes the available research community, including transcriptome three regions, whole genome sequence, proteome measures. DISCUSSION Inclusion traditionally underrepresented groups is essential discover full spectrum medicine targets that will be pertinent all populations with
Язык: Английский
Процитировано
6
Alzheimer s & Dementia Translational Research & Clinical Interventions, Год журнала: 2024, Номер 10(1)
Опубликована: Янв. 1, 2024
Abstract INTRODUCTION Alzheimer's disease (AD) is a complex influenced by genetics and environment. More than 75 susceptibility loci have been linked to late‐onset AD, but most of these were discovered in genome‐wide association studies (GWAS) exclusive non‐Hispanic White individuals. There are wide disparities AD risk across racially stratified groups, while not due genetic differences, underrepresentation research can further exacerbate contribute their persistence. We investigated the racial/ethnic representation participants United States (US)‐based statistical implications current representation. METHODS compared data from array sequencing US databases, including National Institute on Aging Genetics Disease Data Storage Site (NIAGADS) NIAGADS Sharing Service (dssNIAGADS), related dementia (ADRD) prevalence mortality. then simulated power datasets identify variants non‐White populations. RESULTS insufficient (probability <80%) detect single nucleotide polymorphisms (SNPs) with low moderate effect sizes (odds ratio [OR]<1.5) using Black Hispanic participants; Asian powered OR <= 2. Using available projected participants, = 1.2 detectable at high allele frequencies. Sample remain insufficiently DISCUSSION largely representative ADRD burden. However, there discrepancy between proportional statistically meaningful Most variation identified GWAS individuals effects. Comparable populations given sample sizes, which could lead future drug development. urge researchers institutions continue investing recruiting diverse use community‐based participatory practices.
Язык: Английский
Процитировано
5
Alzheimer s & Dementia, Год журнала: 2024, Номер 20(6), С. 4315 - 4330
Опубликована: Май 6, 2024
We investigate Alzheimer's disease and related dementia (ADRD) prevalence, incidence rate, risk factors in individuals racialized as Asian and/or Asian-American assess sample representation. Prevalence, factors, heterogeneity of samples were assessed. Random-effects meta-analysis was conducted, generating pooled estimates. Of 920 records across 14 databases, 45 studies included. Individuals mainly from Eastern Southern Asia, had higher education, constituted a smaller relative to non-Hispanic white cohorts. The average prevalence 10.9%, ranging 0.4% 46%. rate 20.03 (12.01-33.8) per 1000 person-years with range 75.19-13.59 (12.89-14.33). Risk included physiological, genetic, psychological, behavioral, social factors. This review underscores the systemic underrepresentation ADRD research need for inclusive approaches accounting culture, language, immigration status. HIGHLIGHTS: There is considerable among Asian-Americans. limited data on group-specific Asian-Americans found be 7.4%, wide 0.5%
Язык: Английский
Процитировано
4