AJPM Focus, Год журнала: 2025, Номер 4(3), С. 100324 - 100324
Опубликована: Фев. 17, 2025
Язык: Английский
Alzheimer s & Dementia, Год журнала: 2024, Номер 20(6), С. 4315 - 4330
Опубликована: Май 6, 2024
We investigate Alzheimer's disease and related dementia (ADRD) prevalence, incidence rate, risk factors in individuals racialized as Asian and/or Asian-American assess sample representation. Prevalence, factors, heterogeneity of samples were assessed. Random-effects meta-analysis was conducted, generating pooled estimates. Of 920 records across 14 databases, 45 studies included. Individuals mainly from Eastern Southern Asia, had higher education, constituted a smaller relative to non-Hispanic white cohorts. The average prevalence 10.9%, ranging 0.4% 46%. rate 20.03 (12.01-33.8) per 1000 person-years with range 75.19-13.59 (12.89-14.33). Risk included physiological, genetic, psychological, behavioral, social factors. This review underscores the systemic underrepresentation ADRD research need for inclusive approaches accounting culture, language, immigration status. HIGHLIGHTS: There is considerable among Asian-Americans. limited data on group-specific Asian-Americans found be 7.4%, wide 0.5%
Язык: Английский
Процитировано
4
Alzheimer s & Dementia Translational Research & Clinical Interventions, Год журнала: 2024, Номер 10(2)
Опубликована: Апрель 1, 2024
Abstract INTRODUCTION This ongoing, prospective study examines the effectiveness of methods used to successfully recruit and retain 238 Black older adults in a longitudinal, observational Alzheimer's disease (AD) study. METHODS Recruitment strategies included traditional media, established research registries, speaking engagements, community events, snowball sampling. Participants were asked complete an annual office testing session, blood‐based biomarker collection, optional one‐time magnetic resonance imaging (MRI) scan, workshop. RESULTS Within first 22 months active recruitment, 629 individuals expressed interest participating, enrolled ongoing Of recruitment used, sampling, engagements most effective. DISCUSSION The systemic underrepresentation participants AD impacts ability generalize findings determine safety disease‐modifying treatments. Research slow, stop, or prevent remains top priority but requires diversity sample representation. Highlights Provide flexible appointments evening weekends, offering transportation assistance, allowing visits at alternative locations, such as senior centers centers. Continuously monitor analyze data identify trends, challenges, opportunities for improvement. Implement targeted who are underrepresented based on sex, gender, education increase Diversify team include members reflect racial cultural backgrounds target population, enhance trust rapport with participants.
Язык: Английский
Процитировано
4
Epilepsy & Behavior, Год журнала: 2024, Номер 158, С. 109927 - 109927
Опубликована: Июль 5, 2024
Язык: Английский
Процитировано
4
Alzheimer s & Dementia, Год журнала: 2024, Номер unknown
Опубликована: Авг. 30, 2024
Abstract INTRODUCTION Multi‐omics studies in Alzheimer's disease (AD) revealed many potential pathways and therapeutic targets. Despite their promise of precision medicine, these lacked Black Americans (BA) Latin (LA), who are disproportionately affected by AD. METHODS To bridge this gap, Accelerating Medicines Partnership Disease (AMP‐AD) expanded brain multi‐omics profiling to multi‐ethnic donors. RESULTS We generated data curated harmonized phenotypic from BA ( n = 306), LA 326), or 4) donors plus non‐Hispanic White 252) other 20) ethnic groups, establish a foundational dataset enriched for participants. This study describes the available research community, including transcriptome three regions, whole genome sequence, proteome measures. DISCUSSION The inclusion traditionally underrepresented groups is essential discovering full spectrum medicine targets that will be pertinent all populations with Highlights Diversity Initiative led tissue populations. Brain American, RNA, sequencing tandem mass tag proteomicsis completed shared. Multiple regions caudate, temporal dorsolateral prefrontal cortex were profiled.
Язык: Английский
Процитировано
4
Journal of the American Geriatrics Society, Год журнала: 2025, Номер unknown
Опубликована: Янв. 6, 2025
See related article by Ganguli et al .
Язык: Английский
Процитировано
0
medRxiv (Cold Spring Harbor Laboratory), Год журнала: 2025, Номер unknown
Опубликована: Янв. 6, 2025
Racial disparities in neuropsychological test performance are well documented Alzheimer's Disease (AD) but have received little attention frontotemporal degeneration (FTD). Identification of potential is critical to identify ways improve inclusivity clinical research and care representative FTD populations. We evaluated among individuals with clinically diagnosed (behavioral variant [bvFTD] or primary progressive aphasia [PPA]) using data from the National Coordinating Center (NACC) collected between September 2005 November 2023. Only 10% NACC cases racially/ethnically minoritized groups. Black (n=56), Hispanic (n=77) White (n=1301) were cognitive domains episodic memory, working processing speed, flexibility, attention, category fluency lexical retrieval, addition global cognition across Uniform Data Set versions 1 3. Linear regressions examined association racial/ethnic group scores covarying for disease stage, age, sex, education. After adjusting education established normative correction, binary logistic regression differences proportion participants classified as impaired (<=-1.5 z-score) each test. Minoritized individuals, on average, had lower and/or greater likelihood impairment (odds ratio; OR) measures (Black: β = -3.63; OR 2.74; Hispanic: -2.50), retrieval -4.31; 3.28; -2.90; 3.81), speed 26.80; 4.07; 21.31; 2.37), flexibility 46.65; 3.35), (Hispanic: -0.39), memory -0.79; -0.42), -1.67), -1.28). did not any tests where performed worse than individuals. These findings indicate cognition, executive function, retrieval. Critically, these used diagnosis monitoring FTD. Future efforts must focus increasing participation underrepresented populations support diverse needs an understanding social determinants health evaluate sources observed racial ethnic
Язык: Английский
Процитировано
0
PLoS ONE, Год журнала: 2025, Номер 20(1), С. e0312660 - e0312660
Опубликована: Янв. 13, 2025
Ambient air pollution, detrimental built and social environments, isolation (SI), low socioeconomic status (SES), rural (versus urban) residence have been associated with cognitive decline risk of Alzheimer's disease related dementias (ADRD). Research is needed to investigate the influence ambient pollution environments on SI among rural, disadvantaged, ethnic minority communities. To address this gap, cohort study will recruit an ethnoracially diverse, Florida sample in geographic proximity seasonal agricultural burning. We (1) examine contributions smoke-related fine particulate matter (PM2.5) exposures function; (2) determine effects (3) contextualize function residents from different ethnoracial groups during burn non-burn seasons. 1,087 community-dwelling, dementia-free, ≥45-year-olds five communities Florida's Lake Okeechobee region. Over 36 months, participants complete baseline visits collect demographics, health history, measurements (e.g., blood pressure, body mass index) 6-month follow-ups assessing at each visit. A subsample 120 representative community wear smartwatches sensor data heart rate) daily routine predefined activities GPS-captured travel, frequent destinations) over two months. Ecological momentary assessments (EMA) whether smoke has bothered participant last 30 minutes) occur months burning non-burning PurpleAir monitors (36 total) be installed continuously monitor outdoor PM2.5 levels. expect identify individual- community-level factors that increase for a vulnerable population.
Язык: Английский
Процитировано
0
Brain Sciences, Год журнала: 2025, Номер 15(1), С. 90 - 90
Опубликована: Янв. 18, 2025
Background/Objectives: Sexual minority older adults (SMOAs) report greater subjective cognitive decline (SCD) than heterosexual (HOAs). This study aimed to compare the impact of multiple psycho-social risk factors on objective and in HOAs SMOAs. Methods: Two samples self-identified SMOAs were selected from English Longitudinal Study Ageing. Reliable change indices for episodic semantic memory created assess decline. SCD was self-reported general cognition. Depressive symptoms, loneliness, marital status socio-economic investigated as factors. Results: No between-group differences found Higher depression associated with worse The latter effect stronger findings largely replicated sensitivity analysis. Conclusions: Poor mental health may represent strongest driver a extent HOAs.
Язык: Английский
Процитировано
0
The Clinical Neuropsychologist, Год журнала: 2025, Номер unknown, С. 1 - 29
Опубликована: Янв. 26, 2025
Background: Exposure to repetitive head impacts (RHI), such as those experienced in American football, is linked cognitive dysfunction later life. Traumatic encephalopathy syndrome (TES) a proposed clinical thought be neuropath-ology of chronic traumatic (CTE), condition associated with RHI from football. Cognitive intra-individual variability (d-CIIV) measures test-score dispersion, indicating dysfunction. This study examined d-CIIV former football players and its associations TES diagnosis, exposure, DTI CSF biomarkers. Methods: Data included 237 males (45-74 years) DIAGNOSE CTE Research Project, including professional college (COL) (n = 173) asymptomatic men without or TBI 55). Participants completed neuropsychological tests. diagnosis was based on 2021 NINDS criteria. Years play cumulative impact index (CHII) measured exposure. Lumipulse technology used for assays. fractional anisotropy assessed white matter integrity. Coefficient variation (CoV) d-CIIV. ANCOVA compared among groups (football versus control; TES-status). Pearson correlations linear regressions tested between d-CIIV, Results: Former had higher than controls (F(7, 194) 2.87, p .007). (F(8, 146) 9.063, < .001), highest Possible/Probable-CTE. Higher correlated CHII scores (r 0.19), reduced Aβ1-42 (β -0.302), increased p-tau181 0.374), FA -0.202). Conclusion: exposure players, changes biomarkers
Язык: Английский
Процитировано
0
Human Brain Mapping, Год журнала: 2025, Номер 46(2)
Опубликована: Янв. 27, 2025
Neurodegeneration is presumed to be the pathological process measure most proximal clinical symptom onset in Alzheimer Disease (AD). Structural MRI routinely collected research and trial settings. Several quantitative MRI-based measures of atrophy have been proposed, but their low correspondence with each other has previously documented. The purpose this study was identify which commonly used structural (hippocampal volume, cortical thickness AD signature regions, or brain age gap [BAG]) had best Clinical Dementia Rating (CDR) an ethno-racially diverse sample. 2870 individuals recruited by Healthy Aging Brain Study-Health Disparities completed both CDR evaluation. Of these, 1887 were matched on ethno-racial identity (Mexican American [MA], non-Hispanic Black [NHB], White [NHW]) (27% > 0). We estimated using two pipelines (DeepBrainNet, BrainAgeR) then calculated BAG as difference between chronological age. also quantified hippocampal volumes HippoDeep thicknesses (both AD-specific average whole brain) FreeSurfer. ordinal regression evaluate associations neuroimaging test whether these differed groups. Higher (pDeepBrainNet = 0.0002; pBrainAgeR 0.00117) lower volume (p 0.0015) < 0.0001) associated worse status (higher CDR). strongest relationship (AICDeepBrainNet 2623, AICwhole cortex 2588, AICBrainAgeR 2533, AICHippocampus 2293, AICSignature Cortical Thickness 1903). groups for estimates not thickness. interpret lack interaction evidence that effectively captures sources disease-related may differ across racial ethnic association CDR. These results suggest a more sensitive generalizable marker neurodegeneration than cohorts.
Язык: Английский
Процитировано
0