European Journal of Neurology, Год журнала: 2024, Номер unknown
Опубликована: Сен. 27, 2024
Emerging evidence has linked impaired kidney function with dementia in older adults, but the neuropathological pathways underlying their association remain poorly understood. We sought to examine relationships of and plasma biomarkers a Chinese rural population.
Язык: Английский
Progress in Retinal and Eye Research, Год журнала: 2024, Номер 101, С. 101273 - 101273
Опубликована: Май 15, 2024
The retina is an emerging CNS target for potential noninvasive diagnosis and tracking of Alzheimer's disease (AD). Studies have identified the pathological hallmarks AD, including amyloid β-protein (Aβ) deposits abnormal tau protein isoforms, in retinas AD patients animal models. Moreover, structural functional vascular abnormalities such as reduced blood flow, Aβ deposition, blood-retinal barrier damage, along with inflammation neurodegeneration, been described mild cognitive impairment dementia. Histological, biochemical, clinical studies demonstrated that nature severity pathologies brain correspond. Proteomics analysis revealed a similar pattern dysregulated proteins biological pathways patients, enhanced inflammatory neurodegenerative processes, impaired oxidative-phosphorylation, mitochondrial dysfunction. Notably, investigational imaging technologies can now detect AD-specific deposits, well vasculopathy neurodegeneration living suggesting alterations at different stages links to pathology. Current exploratory ophthalmic modalities, optical coherence tomography (OCT), OCT-angiography, confocal scanning laser ophthalmoscopy, hyperspectral imaging, may offer promise assessment AD. However, further research needed deepen our understanding AD's impact on its progression. To advance this field, future require replication larger diverse cohorts confirmed biomarkers standardized retinal techniques. This will validate aiding early screening monitoring.
Язык: Английский
Процитировано
21
Alzheimer s & Dementia, Год журнала: 2024, Номер 20(7), С. 4583 - 4593
Опубликована: Июнь 12, 2024
Mild cognitive impairment (MCI) heightens Alzheimer's disease (AD) risk, with diabetes mellitus (DM) potentially exacerbating this vulnerability. This study identifies the optimal intervention period and neurobiological targets in MCI to AD progression using Disease Neuroimaging Initiative dataset.
Язык: Английский
Процитировано
14
Alcohol research, Год журнала: 2024, Номер 44(1)
Опубликована: Янв. 1, 2024
PURPOSE:By 2040, 21.6% of Americans will be over age 65, and the population those older than 85 is estimated to reach 14.4 million.Although not causative, a risk factor for dementia: every 5 years beyond doubles; approximately one-third are diagnosed with dementia.As current alcohol consumption among adults significantly higher compared previous generations, pressing question whether drinking increases Alzheimer's disease or other forms dementia.SEARCH METHODS: Databases explored included PubMed, Web Science, ScienceDirect.To accomplish this narrative review on effects dementia risk, literature covered clinical diagnoses, epidemiology, neuropsychology, postmortem pathology, neuroimaging biomarkers, translational studies.Searches conducted between January 12 August 1, 2023, following terms combinations: "aging," "alcoholism," "alcohol use disorder (AUD)," "brain," "CNS," "dementia," "Wernicke," "Korsakoff," "Alzheimer," "vascular," "frontotemporal," "Lewy body," "clinical," "diagnosis," "epidemiology," "pathology," "autopsy," "postmortem," "histology," "cognitive," "motor," "neuropsychological," "magnetic resonance," "imaging," "PET," "ligand," "degeneration," "atrophy," "translational," "rodent," "rat," "mouse," "model," "amyloid," "neurofibrillary tangles," "α-synuclein," "presenilin."When relevant, "species" (i.e., "humans" "other animals") was selected as an additional filter.Review articles were avoided when possible.SEARCH RESULTS: The two "alcoholism" "aging" retrieved about 1,350 papers; adding phrases-for example, "postmortem" resonance"-limited number fewer 100 papers.Using traditional term, "dementia" resulted in 876 citations, but using currently accepted term (AUD)" produced only 87 papers.Similarly, whereas "Alzheimer's" yielded 318 results, returned 40 citations.As pertinent pathology papers published 1950s recent animal models created early 2000s, referenced span 1957 2024.In total, more 5,000 considered; 400 herein referenced.DISCUSSION AND CONCLUSIONS: Chronic misuse accelerates brain aging contributes cognitive impairments, including mnemonic domain.The consensus studies from multiple disciplines, however, that can increase dementia, necessarily disease.Key issues consider include reversibility damage abstinence chronic degenerative progressive course disease, characteristic presence protein inclusions brains people which absent AUD.
Язык: Английский
Процитировано
8
Alzheimer s & Dementia, Год журнала: 2023, Номер 20(3), С. 1550 - 1561
Опубликована: Дек. 2, 2023
Abstract INTRODUCTION To examine the burden and clusters of multimorbidity in association with mild cognitive impairment (MCI), dementia, Alzheimer's disease (AD)‐related plasma biomarkers among older adults. METHODS This population‐based study included 5432 participants (age ≥60 years); these, amyloid beta (Aβ), total tau, neurofilament light chain (NfL) were measured a subsample ( n = 1412). We used hierarchical clustering to generate five from 23 chronic diseases. diagnosed dementia MCI following international criteria. Data analyzed using logistic linear regression models. RESULTS The number diseases was associated (multivariable‐adjusted odds ratio 1.22; 95% confidence interval [CI] 1.11 1.33), AD (1.13; 1.01 1.26), vascular (VaD) (1.44; 1.25 1.64), non‐amnestic (1.25; 1.13 1.37). Metabolic cluster VaD MCI, whereas degenerative ocular p < 0.05). increased Aβ NfL DISCUSSION Multimorbidity are differentially subtypes AD‐related Highlights multimorbidity. presence load impairment. biomarkers.
Язык: Английский
Процитировано
14
Geriatric Nursing, Год журнала: 2025, Номер 61, С. 614 - 621
Опубликована: Янв. 1, 2025
Язык: Английский
Процитировано
0
Elsevier eBooks, Год журнала: 2025, Номер unknown, С. 265 - 288
Опубликована: Янв. 1, 2025
Язык: Английский
Процитировано
0
Brain Communications, Год журнала: 2024, Номер 6(3)
Опубликована: Янв. 1, 2024
Abstract The neuropathological mechanisms underlying the association between sleep duration and mild cognitive impairment remain poorly understood. This population-based study included 2032 dementia-free people (age ≥ 60 years; 55.1% women) derived from participants in Multimodal Interventions to Delay Dementia Disability Rural China; of these, data were available 841 for Alzheimer’s plasma biomarkers (e.g. amyloid-β, total tau neurofilament light chain), 1044 serum microvascular soluble adhesion molecules) 834 brain MRI whiter matter, grey hippocampus, lacunes, enlarged perivascular spaces white matter hyperintensity WMH). We used electrocardiogram-based cardiopulmonary coupling analysis measure duration, a neuropsychological test battery assess function Petersen’s criteria define impairment. Data analysed with multivariable logistic general linear models. In sample (n = 2032), 510 defined impairment, including 438 amnestic 72 non-amnestic Long (>8 versus 6–8 h) was significantly associated increased likelihoods lower scores global cognition, verbal fluency, attention executive (Bonferroni-corrected P < 0.05). subsamples, long higher amyloid-β40 tau, amyloid-β42/amyloid-β40 ratio smaller volume Sleep not serum-soluble molecules, volume, lacunes (P > neurodegenerative pathologies may represent common pathways linking low cognition older adults.
Язык: Английский
Процитировано
4
Alzheimer s & Dementia, Год журнала: 2025, Номер unknown
Опубликована: Янв. 17, 2025
Abstract INTRODUCTION To examine the longitudinal association between estimated pulse wave velocity (ePWV) and cognitive phenotypes in a rural Chinese older population. METHODS This population‐based study included 1857 dementia‐free participants (age ≥60 years) who were examined 2014 followed 2018. ePWV was calculated using age mean blood pressure (MBP). Cognitive function assessed Mini‐Mental State Examination (MMSE) neuropsychological tests. Dementia diagnosed following Diagnostic Statistical Manual of Mental Disorders, Fourth Edition (DSM‐IV) criteria. Data analyzed Cox proportional‐hazards models, linear regression restricted cubic spline (RCS) curves. RESULTS Per 1‐m/s increase associated with an adjusted hazard ratio (HR) (95% confidence interval [CI]) 1.51(1.30–1.75) for dementia 1.58(1.33–1.89) Alzheimer's disease (AD), MMSE score decline (adjusted β ‐coefficient = −0.36; 95% CI −0.52 to −0.21). A nonlinear observed baseline follow‐up scores. DISCUSSION higher is increased risk dementia, AD, accelerated decline, poorer performance adults. Highlights An incident disease, at lower scores global cognition multiple domains 4‐year follow‐up. may be factor deterioration aging.
Язык: Английский
Процитировано
0
Опубликована: Янв. 1, 2025
Язык: Английский
Процитировано
0
Alzheimer s & Dementia Translational Research & Clinical Interventions, Год журнала: 2025, Номер 11(1)
Опубликована: Янв. 1, 2025
Abstract The rising age of the global population has made Alzheimer's disease and related dementias (ADRD) a critical public health problem, with significant health‐related disparities observed between rural urban areas. However, no previous reviews have examined scope determinant factors contributing to rural–urban ADRD‐related outcomes. This study aims systematically collate synthesize peer‐reviewed articles on in ADRD, identifying key determinants research gaps guide future research. We conducted systematic search using terms ADRD without restrictions geography or design. Five engines—MEDLINE, CINAHL, Web Science, PubMed, Scopus—were used identify relevant articles. was performed August 16, 2024, included English‐language published from 2000 onward. Sixty‐three met eligibility criteria for data extraction synthesis. Most were after 2010 (85.7%) concentrated United States, China, Canada (66.7%). A majority had cross‐sectional (58.7%) cohort designs (23.8%), primarily examining prevalence (41.3%) incidence (11.1%). Findings often indicated higher areas, although inconsistent classification systems noted. Common risk female sex, lower education level, income, comorbidities such as diabetes cerebrovascular diseases. Environmental (12.7%) lifestyle (14.3%) been less explored. statistical methods mainly traditional analyses (e.g., logistic regression) lacked advanced techniques machine learning causal inference methods. identified this review emphasize need underexplored geographic regions encourage use investigate understudied disparities, environmental, lifestyle, genetic influences. Highlights Few studies focus low‐ middle‐income countries. include low attainment, comorbidities. Inconsistent definitions “rural” complicate cross‐country comparisons. affecting are underexplored. Advanced methods, inference, recommended.
Язык: Английский
Процитировано
0