Relationships among cortical activation, cognition, and blood biomarkers in two types of dementia determined using functional near-infrared spectroscopy

Frontiers in Neurology, Год журнала: 2025, Номер 16

Опубликована: Апрель 14, 2025

Objective The most prevalent types of dementia in older adults are Alzheimer's disease (AD) and Lewy body (LBD), they have overlapping clinical symptoms. We aimed to define amounts cortical activation identify indicators brain function better distinguish between these aid diagnosis using functional near-infrared spectroscopy (fNIRS). Methods Oxygenated hemoglobin (HbO) concentrations the brains patients with AD LBD were detected fNIRS. Brain was assessed a verbal fluency task (VFT). Resting-state task-state activations investigated determine differences LBD. Blood samples analyzed relevant biomarkers. HbO variables compared Functional connectivity at rest correlations blood biomarkers analyzed. sensitivity specificity parameters for differentiating dementias evaluated areas under receiver operating characteristic (ROC) curves (AUCs). Results This study recruited 28 inpatients 25 Mean did not significantly differ resting state ( p > 0.05), whereas differed t = −3.449, 0.001) groups. during VFT, lower left temporal 0.031), right dorsolateral prefrontal 0.001), 0.011) cortices AD, than group. amyloid-β (Aβ) 42 levels higher group 0.023), more α-synuclein expressed 0.012). Correlation analysis cognition-related associated plasma Aβ level pre-motor supplementary motor cortex r −0.378; 0.005) glial fibrillary acidic protein (GFAP) pars triangularis 0.006) rest. Levels biomarker negatively correlated −0.329, 0.016) VFT. AUC combination multiple fNIRS individual cognitive or (AUC 0.9314). Conclusion characteristics measured can help from adults.

Язык: Английский

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Genetic risk and plasma biomarkers of dementia with Lewy bodies in a Chinese population

npj Parkinson s Disease, Год журнала: 2025, Номер 11(1)

Опубликована: Май 15, 2025

Genetic investigations and associations with plasma biomarkers of dementia Lewy bodies (DLB) in East Asian populations are lacking. The aim our study is to identify candidate pathogenic variants assess the diagnostic performance among DLB patients Chinese population. This cohort included 151 2010 controls, all whom underwent whole genome sequencing. Plasma glial fibrillary acidic protein (GFAP), α-synuclein(αSyn), neurofilament light (NfL), phosphorylated tau 217 (p-tau217) were detected a subgroup. As result, APOE ε4 allele significantly increased risk (p = 1.84E-11), while rare missense USP13 gene first found be suggestively associated 1.31E-5). Higher levels GFAP, αSyn, NfL, p-tau217 compared controls < 0.001), which combined polygenic scores (PRS) achieving an AUC 0.927 for diagnosis. Besides, significant correlations observed between PRS age at onset, cumulative incidence rate, as well GFAP levels. In conclusion, this simultaneously investigate genetics DLB, highlighting discriminative ability using biomarker assay.

Язык: Английский

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Plasma Phosphorylated Tau181 as a Biomarker for Alzheimer's Disease Co‐Pathology in Lewy Body Disease

Movement Disorders, Год журнала: 2025, Номер unknown

Опубликована: Май 29, 2025

ABSTRACT Background Plasma phosphorylated tau181 (pTau181) is proving to be a useful predictor of Alzheimer's disease (AD). AD co‐pathology frequently observed across the Lewy body (LBD) spectrum. Objective To determine whether pTau181 in LBD associated with postmortem neuropathologic changes (ADNC) and antemortem positron emission spectrometry measurements β‐amyloid tau deposition. Methods We studied 53 participants who underwent plasma assessment, contrasting them 129 healthy control 67 AD. Postmortem assessments were conducted on 24 cases. Spearman correlation analyses used assess association between severity amyloid deposits, accumulation, neurodegeneration (A/T/N) measured at autopsy or via neuroimaging. Results was higher than lower participants. moderately correlated Thal stage, Braak neurofibrillary tangle (NFT) CERAD (Consortium Establish Registry for Disease) scores but not stage. cortical PiB (Pittsburgh Compound‐B) retention. Elevated levels greater thinning, particularly later NFT regions. The addition improved models that included age, sex, APOE ε4 detect positivity. Conclusions reflects pathology α‐synuclein LBD. indicator regions vulnerable adds value identifying co‐pathology. These findings support as cost‐effective screening tool © 2025 International Parkinson Movement Disorder Society.

Язык: Английский

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Exploratory Blood Biomarker Patterns in a Mixed Dementia Cohort

medRxiv (Cold Spring Harbor Laboratory), Год журнала: 2024, Номер unknown

Опубликована: Ноя. 8, 2024

Abstract Alzheimer’s disease (AD) diagnosis is challenging due to overlapping symptoms with other dementias. Current diagnostic methods are invasive and costly, highlighting the need for accessible biomarkers. This study investigates performance pathophysiological implications of a novel plasma biomarker panel in mixed dementia cohort, aiming enhance elucidate underlying pathogenic mechanisms. 120 biomarkers were analyzed using NULISA™ platform well-characterized mixt dementia. CSF measured via ELISA. Statistical analyses employed ANOVA, Kruskal-Wallis tests group comparisons. Spearman correlations assessed relationships between Diagnostic accuracy was evaluated regression models ROC curves. Feature importance selection performed random forest analysis. Protein interactions GO enrichment We 248 subjects (130 females, 118 males) 117 AD, 50 MCI, 39 FTD, 25 DLB, 17 Plasma pTau significantly elevated AD compared groups, DLB MCI. Aβ42 highest while NfL FTD. GFAP MCI levels showed negative correlation positive entire cohort. also highly correlated. These stronger amyloid-positive groups but weaker or absent group. pTau, GFAP, negatively correlated MMSE FTD DLB. pTau217 demonstrated best amyloid positivity (AUCs 0.9, 0.84, 0.79, 0.87, respectively). pTau181, pTau217, pTau231, total-tau had lower odds AD. AGRN, CXCL1, SCNB, TEK, UCHL1 higher SNAP25 ratio MAPT, PGF related progression. Random analysis incorporating all biomarkers, age, gender yielded an AUCs 0.85 0.84 0.75 Refining model by including identified as significant improved performance, resulting 0.88 0.87 0.81 demonstrates potential enhancing through targeted refinement.

Язык: Английский

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Comparison of Plasma p-tau217 and [ ¹⁸ F]FDG-PET for Identifying Alzheimer Disease in People With Early-Onset or Atypical Dementia

Neurology, Год журнала: 2024, Номер 104(2)

Опубликована: Дек. 23, 2024

To compare the diagnostic performance of an immunoassay for plasma concentrations phosphorylated tau (p-tau) 217 with visual assessments fluorine-18 fluorodeoxyglucose [

Язык: Английский

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