TaiChi-MSS protocol: enhancing cognitive and brain function in MCI patients through Tai Chi exercise combined with multisensory stimulation
Frontiers in Aging Neuroscience,
Год журнала:
2025,
Номер
17
Опубликована: Фев. 25, 2025
The
aging
population
in
China
is
confronted
with
considerable
challenges,
14.71%
of
elderly
individuals
affected
by
mild
cognitive
impairment
(MCI).
practice
Tai
Chi
has
been
demonstrated
to
enhance
function,
while
sensory
stimulation
shown
facilitate
neural
activity.
Nevertheless,
the
combined
impact
and
on
cognitive,
functions,
brain
activation
older
adults
MCI
remains
uncertain.
This
study
aims
ascertain
whether
integration
can
more
efficacious
interventions
for
these
outcomes.
TaiChi-MSS
(Tai
Multisensory
Stimulation
Cognitive
Function)
a
multi-center,
randomized
controlled
trial
(RCT)
conducted
Suzhou
Shanghai,
enrolling
88
participants
aged
60
years
or
MCI.
Participants
will
be
randomly
assigned
one
four
groups:
Chi,
multisensory
stimulation,
control.
intervention
last
6
months,
follow-up
assessments
at
3,
6,
9
months.
Primary
outcomes
include
assessments,
assessed
using
Montreal
Assessment
(MoCA),
Mini-Mental
State
Examination
(MMSE),
domain-specific
tests,
Pure
Tone
Audiometry
(PTA),
Sniffin'
Sticks
Odor
Identification
Test.
Secondary
involve
activation,
measured
through
functional
Magnetic
Resonance
Imaging
(fMRI)
scans.
fMRI
used
assess
structure
connectivity
changes,
focusing
neuroplasticity.
Data
analyzed
mixed-effects
models.
False
Discovery
Rate
(FDR)
correction
method
multiple
comparisons
control
expected
proportion
false
positives.
was
approved
ethics
committee
Shanghai
University
Sport
(No.
102772023RT200).
results
this
disseminated
peer-reviewed
journals
presented
academic
conferences.
Язык: Английский
Sensory and motor deficits as contributors to early cognitive impairment
Alzheimer s & Dementia,
Год журнала:
2024,
Номер
20(4), С. 2653 - 2661
Опубликована: Фев. 20, 2024
Abstract
INTRODUCTION
Age‐related
sensory
and
motor
impairment
are
associated
with
risk
of
dementia.
No
study
has
examined
the
joint
associations
multiple
measures
on
prevalence
early
cognitive
(ECI).
METHODS
Six
hundred
fifty
participants
in
Baltimore
Longitudinal
Study
Aging
completed
function
tests.
The
association
between
ECI
was
using
structural
equation
modeling
three
latent
factors
corresponding
to
multisensory,
fine
motor,
gross
function.
RESULTS
fine,
were
all
correlated
(
r
=
0.74
0.81).
odds
lower
for
each
additional
unit
improvement
multisensory
(32%),
(30%),
(12%).
DISCUSSION
relationship
emerging
may
guide
future
intervention
studies
aimed
at
preventing
and/or
treating
ECI.
Highlights
Sensorimotor
(ECI)
assessed
via
modeling.
degree
is
indicators
also
Язык: Английский
Motor abilities and cognitive performance in Latinos with autosomal dominant Alzheimer's disease
The Journal of Prevention of Alzheimer s Disease,
Год журнала:
2025,
Номер
12(1), С. 100010 - 100010
Опубликована: Янв. 1, 2025
Declining
motor
abilities
might
be
a
noninvasive
biomarker
for
Alzheimer's
disease
(AD).
Studying
ability
and
AD
progression
in
younger
Latinos
with
autosomal
dominant
(ADAD)
can
provide
insights
into
the
interplay
between
cognition
individuals
minimal
confounding
from
age-normative
changes
comorbid
medical
conditions.
This
study
aimed
to
(1)
examine
as
function
of
years
dementia
diagnosis
(2)
associations
cognitive
performance.
was
cross-sectional
observational
study.
The
took
place
at
University
Southern
California.
39
predominately
Latino
(mean
age
38.6
±
10
old)
known
carry
(carriers;
n=25)
or
50%
risk
inheriting
ADAD
but
not
carrying
mutation
(noncarriers;
n=14).
Individuals
completed
batteries
National
Institute
Health
Toolbox
(NIHTB)
Cognitive
Abilities
Screening
Instrument
(CASI).
All
models
included
effects
age,
education,
primary
language,
sex.
Compared
noncarriers,
carriers
had
significantly
weaker
grip
strength
12
years,
worse
manual
dexterity
slower
gait
speed
seven
before
expected
diagnosis.
Worse
associated
more
severe
stage
CASI
performance,
adjusting
demographic
clinical
variables.
findings
support
utility
precisely
strength,
dexterity,
potential
biomarkers
preclinical
AD.
Язык: Английский
Mechanical load conditions the spectrin network to `run-on' proteolysis and promotes early onset neurodegeneration
bioRxiv (Cold Spring Harbor Laboratory),
Год журнала:
2024,
Номер
unknown
Опубликована: Ноя. 4, 2024
The
correct
homeostasis
of
the
neuronal
cytoskeleton
and
its
dynamics
is
important
for
health
disease.
Forces
constantly
act
on
neurons
in
our
body,
leading
to
subtle
axonal
deformations
length
changes.
spectrin
known
as
a
key
player
that
protects
against
mechanical
damage.
How
changes
with
age
how
it
influences
mechanoprotection
aging
animals
not
well
understood.
Using
an
interdisciplinary
approach,
we
show
causes
loss
proprioception
during
first
few
days
adulthood
C.
elegans
via
unfolding,
tension
degradation
cytoskeleton.
Guided
by
proteomic
screen
identify
potential
binding
partners,
found
this
early-onset
neurodegeneration
can
be
suppressed
clp-1
mutants
targeted
expression
engineered
chaperone
derived
from
human
α
B-crystallin.
Our
data
suggest
sensitized
proteolytic
damage
calcium-sensitive
proteases
when
stresses
conspires
high-calcium
concentrations
proprioceptive
signaling.
These
results
may
have
implications
etiology
diseases
which
high
calcium
stress
co-incide.
Язык: Английский