Abstract
Monitoring
synaptic
injury
in
neurodegenerative
diseases
may
provide
new
insights
into
the
evolution
of
degenerative
process
as
well
a
potential
mechanism
to
target
for
preservation
function.
Synaptic
density
imaging
with
PET
is
relatively
approach
this
issue.
However,
there
are
remaining
questions
about
technical
approaches
data
analysis
including
reference
region
selection,
and
how
specific
phenotypic
presentations
symptoms
Alzheimer’s
Disease
(AD)
reflected
alterations
density.
Methods
Using
an
SV2A
ligand
radiolabeled
18
F
isotope
([
F]-SynVesT-1)
we
performed
sensitivity
analyses
determine
optimal
tissue
modelling
derive
whole
brain
ratio
images.
these
images
from
sample
young
adults,
older
patients
varied
AD
then
contrast
regional
vivo
biomarkers.
Result
Reference
optimisation
concluded
that
cerebellar
grey
matter
best
deriving
images,
find
strong
inverse
association
between
[
F]-SynVesT-1
uptake
amyloid
beta
tau
deposition.
Finally,
individuals
lower
temporal
volume
but
higher
show
preserved
performance
on
MMSE.
Conclusions
shows
close
pathology
be
possible
marker
resilience
neurodegeneration.
Molecules,
Год журнала:
2024,
Номер
29(20), С. 4841 - 4841
Опубликована: Окт. 12, 2024
This
review
explores
the
potential
health
benefits
and
applications
of
phenolic
secoiridoids
derived
from
olive
oil
by-products
in
prevention
Alzheimer's
disease
(AD).
As
reviewed
herein,
polyphenols,
such
as
epigallocatechin-3-gallate,
epicatechin,
resveratrol,
show
vitro
vivo
antioxidant,
anti-inflammatory,
neuroprotective
properties,
are
particularly
relevant
context
AD,
a
leading
cause
dementia
globally.
The
industry,
Mediterranean
region,
produces
significant
amounts
waste,
including
leaves,
pomace,
wastewater,
which
pose
environmental
challenges
but
also
offer
an
untapped
source
bioactive
compounds.
Despite
promising
studies
indicating
that
olive-derived
oleuropein
hydroxytyrosol,
may
mitigate
AD
pathology,
human
clinical
trials
remain
limited.
variability
extraction
methods
complex
nature
further
complicate
research.
Future
should
focus
on
standardizing
protocols
conducting
robust
to
fully
assess
therapeutic
these
approach
not
only
supports
development
new
treatments
for
promotes
sustainability
by
valorizing
industry
waste.
Alzheimer s & Dementia,
Год журнала:
2024,
Номер
unknown
Опубликована: Окт. 30, 2024
Abstract
INTRODUCTION
We
investigated
hippocampal
synaptic
density
using
vesicle
2A
positron
emission
tomography
(PET),
and
its
association
with
amyloid
beta
(Aβ)
cognitive
performance
in
healthy
apolipoprotein
E
(
APOE
)
ε4
carriers.
METHODS
Synaptic
was
assessed
46
individuals
ε4/ε4
n
=
14;
ε3/ε4
16;
ε3/ε3
16)
[
11
C]UCB‐J‐PET
standardized
uptake
value
ratios
(SUVRs),
by
the
centrum
semiovale
as
a
reference
region.
Differences
C]UCB‐J
SUVRs
were
analyzed
analysis
of
variance
(ANOVA)
linear
models.
Associations
among
SUVR,
Aβ,
volume,
variables
Spearman
correlation.
RESULTS
Hippocampal
different
groups
P
ANOVA
0.016):
carriers
had
lower
compared
to
p
0.013).
did
not
correlate
Consortium
Establish
Registry
for
Alzheimer's
Disease
(CERAD)
total
score
(rho
−0.052,
0.74),
Prevention
Initiative
Preclinical
Cognitive
Composite
(APCC)
0.17,
0.28),
or
C]PiB
−0.10,
0.50).
DISCUSSION
loss
emerges
early
AD
continuum
is
measurable
vivo
cognitively
unimpaired
high‐risk
individuals.
Highlights
studied
older
adults
tomography.
Apolipoprotein
ε3/ε3.
associated
this
population.
alterations
occur
before
clinical
symptoms
Alzheimer s & Dementia,
Год журнала:
2024,
Номер
unknown
Опубликована: Дек. 13, 2024
Abstract
INTRODUCTION
Progressive
supranuclear
palsy
(PSP)
is
a
devastating
4R
tauopathy
affecting
motor
functions
and
often
misdiagnosed/underdiagnosed
due
to
lack
of
specific
biomarkers.
Synaptic
loss
an
eminent
feature
tauopathies
including
PSP.
Novel
synaptic
positron
emission
tomography
tracer
UCB‐J
holds
great
potential
for
early
diagnosis;
however,
there
substantial
knowledge
gap
in
terms
the
mechanism
extent
nature
METHODS
Here,
we
report
in‐depth
post
mortem
validation
mechanistic
study
PSP
control
brains
using
radioligand/autoradiography
binding
studies,
alongside
biochemical
correlation
analyses
markers.
RESULTS
AND
DISCUSSION
3
H‐UCB‐J
targeted
vesicle
protein
2A
with
high
specificity
demonstrated
distinct
interrelation
markers
patients’
brain
regions.
The
severely
affected
globus
pallidus
revealed
deficits
glutamate/GABAergic
terminals.
Cortical
subcortical
tau
load
differentially
impacted
marker
profiles
across
patients,
warranting
further
investigation.
Highlights
progressive
conserved
single
nM
site
different
depicted
prominent
at
synaptosome
levels
terminals
as
compared
control.
distinctly
influenced
profile
patients
highlighted
that
presynaptic
“ubiquitous”
individually
might
not
be
able
represent
complete
state
deficits/loss
brains.
Abstract
Monitoring
synaptic
injury
in
neurodegenerative
diseases
may
provide
new
insights
into
the
evolution
of
degenerative
process
as
well
a
potential
mechanism
to
target
for
preservation
function.
Synaptic
density
imaging
with
PET
is
relatively
approach
this
issue.
However,
there
are
remaining
questions
about
technical
approaches
data
analysis
including
reference
region
selection,
and
how
specific
phenotypic
presentations
symptoms
Alzheimer’s
Disease
(AD)
reflected
alterations
density.
Methods
Using
an
SV2A
ligand
radiolabeled
18
F
isotope
([
F]-SynVesT-1)
we
performed
sensitivity
analyses
determine
optimal
tissue
modelling
derive
whole
brain
ratio
images.
these
images
from
sample
young
adults,
older
patients
varied
AD
then
contrast
regional
vivo
biomarkers.
Result
Reference
optimisation
concluded
that
cerebellar
grey
matter
best
deriving
images,
find
strong
inverse
association
between
[
F]-SynVesT-1
uptake
amyloid
beta
tau
deposition.
Finally,
individuals
lower
temporal
volume
but
higher
show
preserved
performance
on
MMSE.
Conclusions
shows
close
pathology
be
possible
marker
resilience
neurodegeneration.