Post mortem validation and mechanistic study of UCB‐J in progressive supranuclear palsy patients’ brains DOI Creative Commons
Miriam Scarpa,

Elisavet Vallera,

Sira Ausellé‐Bosch

и другие.

Alzheimer s & Dementia, Год журнала: 2024, Номер unknown

Опубликована: Дек. 13, 2024

Abstract INTRODUCTION Progressive supranuclear palsy (PSP) is a devastating 4R tauopathy affecting motor functions and often misdiagnosed/underdiagnosed due to lack of specific biomarkers. Synaptic loss an eminent feature tauopathies including PSP. Novel synaptic positron emission tomography tracer UCB‐J holds great potential for early diagnosis; however, there substantial knowledge gap in terms the mechanism extent nature METHODS Here, we report in‐depth post mortem validation mechanistic study PSP control brains using radioligand/autoradiography binding studies, alongside biochemical correlation analyses markers. RESULTS AND DISCUSSION 3 H‐UCB‐J targeted vesicle protein 2A with high specificity demonstrated distinct interrelation markers patients’ brain regions. The severely affected globus pallidus revealed deficits glutamate/GABAergic terminals. Cortical subcortical tau load differentially impacted marker profiles across patients, warranting further investigation. Highlights progressive conserved single nM site different depicted prominent at synaptosome levels terminals as compared control. distinctly influenced profile patients highlighted that presynaptic “ubiquitous” individually might not be able represent complete state deficits/loss brains.

Язык: Английский

Loss of synaptic density in nucleus basalis of meynert indicates distinct neurodegeneration in Alzheimer’s disease: the RJNB-D study DOI
Binyin Li,

Haijuan Chen,

Yingting Zheng

и другие.

European Journal of Nuclear Medicine and Molecular Imaging, Год журнала: 2024, Номер 52(1), С. 134 - 144

Опубликована: Авг. 8, 2024

Язык: Английский

Процитировано

2
Olive Oil Industry By-Products as a Novel Source of Biophenols with a Promising Role in Alzheimer Disease Prevention DOI Creative Commons
Marta Gonçalves, Marlene Costa, Fátima Paiva‐Martins

и другие.

Molecules, Год журнала: 2024, Номер 29(20), С. 4841 - 4841

Опубликована: Окт. 12, 2024

This review explores the potential health benefits and applications of phenolic secoiridoids derived from olive oil by-products in prevention Alzheimer's disease (AD). As reviewed herein, polyphenols, such as epigallocatechin-3-gallate, epicatechin, resveratrol, show vitro vivo antioxidant, anti-inflammatory, neuroprotective properties, are particularly relevant context AD, a leading cause dementia globally. The industry, Mediterranean region, produces significant amounts waste, including leaves, pomace, wastewater, which pose environmental challenges but also offer an untapped source bioactive compounds. Despite promising studies indicating that olive-derived oleuropein hydroxytyrosol, may mitigate AD pathology, human clinical trials remain limited. variability extraction methods complex nature further complicate research. Future should focus on standardizing protocols conducting robust to fully assess therapeutic these approach not only supports development new treatments for promotes sustainability by valorizing industry waste.

Язык: Английский

Процитировано

2
SV2A PET shows hippocampal synaptic loss in cognitively unimpaired APOE ε4/ε4 homozygotes DOI Creative Commons
Anniina Snellman, Jouni Tuisku, Mikko Koivumäki

и другие.

Alzheimer s & Dementia, Год журнала: 2024, Номер unknown

Опубликована: Окт. 30, 2024

Abstract INTRODUCTION We investigated hippocampal synaptic density using vesicle 2A positron emission tomography (PET), and its association with amyloid beta (Aβ) cognitive performance in healthy apolipoprotein E ( APOE ) ε4 carriers. METHODS Synaptic was assessed 46 individuals ε4/ε4 n = 14; ε3/ε4 16; ε3/ε3 16) [ 11 C]UCB‐J‐PET standardized uptake value ratios (SUVRs), by the centrum semiovale as a reference region. Differences C]UCB‐J SUVRs were analyzed analysis of variance (ANOVA) linear models. Associations among SUVR, Aβ, volume, variables Spearman correlation. RESULTS Hippocampal different groups P ANOVA 0.016): carriers had lower compared to p 0.013). did not correlate Consortium Establish Registry for Alzheimer's Disease (CERAD) total score (rho −0.052, 0.74), Prevention Initiative Preclinical Cognitive Composite (APCC) 0.17, 0.28), or C]PiB −0.10, 0.50). DISCUSSION loss emerges early AD continuum is measurable vivo cognitively unimpaired high‐risk individuals. Highlights studied older adults tomography. Apolipoprotein ε3/ε3. associated this population. alterations occur before clinical symptoms

Язык: Английский

Процитировано

1
SV2A PET在神经退行性疾病中的应用 DOI

Daji Chen,

Hong JIANG

Scientia Sinica Vitae, Год журнала: 2024, Номер 54(11), С. 2068 - 2078

Опубликована: Июль 24, 2024

Процитировано

0
Imaging synaptic density in ageing and Alzheimer's Disease with [18F]-SynVesT-1 DOI Creative Commons
Joseph Giorgio, David N. Soleimani‐Meigooni, Mustafa Janabi

и другие.

Опубликована: Окт. 26, 2024

Abstract Monitoring synaptic injury in neurodegenerative diseases may provide new insights into the evolution of degenerative process as well a potential mechanism to target for preservation function. Synaptic density imaging with PET is relatively approach this issue. However, there are remaining questions about technical approaches data analysis including reference region selection, and how specific phenotypic presentations symptoms Alzheimer’s Disease (AD) reflected alterations density. Methods Using an SV2A ligand radiolabeled 18 F isotope ([ F]-SynVesT-1) we performed sensitivity analyses determine optimal tissue modelling derive whole brain ratio images. these images from sample young adults, older patients varied AD then contrast regional vivo biomarkers. Result Reference optimisation concluded that cerebellar grey matter best deriving images, find strong inverse association between [ F]-SynVesT-1 uptake amyloid beta tau deposition. Finally, individuals lower temporal volume but higher show preserved performance on MMSE. Conclusions shows close pathology be possible marker resilience neurodegeneration.

Язык: Английский

Процитировано

0
Post mortem validation and mechanistic study of UCB‐J in progressive supranuclear palsy patients’ brains DOI Creative Commons
Miriam Scarpa,

Elisavet Vallera,

Sira Ausellé‐Bosch

и другие.

Alzheimer s & Dementia, Год журнала: 2024, Номер unknown

Опубликована: Дек. 13, 2024

Abstract INTRODUCTION Progressive supranuclear palsy (PSP) is a devastating 4R tauopathy affecting motor functions and often misdiagnosed/underdiagnosed due to lack of specific biomarkers. Synaptic loss an eminent feature tauopathies including PSP. Novel synaptic positron emission tomography tracer UCB‐J holds great potential for early diagnosis; however, there substantial knowledge gap in terms the mechanism extent nature METHODS Here, we report in‐depth post mortem validation mechanistic study PSP control brains using radioligand/autoradiography binding studies, alongside biochemical correlation analyses markers. RESULTS AND DISCUSSION 3 H‐UCB‐J targeted vesicle protein 2A with high specificity demonstrated distinct interrelation markers patients’ brain regions. The severely affected globus pallidus revealed deficits glutamate/GABAergic terminals. Cortical subcortical tau load differentially impacted marker profiles across patients, warranting further investigation. Highlights progressive conserved single nM site different depicted prominent at synaptosome levels terminals as compared control. distinctly influenced profile patients highlighted that presynaptic “ubiquitous” individually might not be able represent complete state deficits/loss brains.

Язык: Английский

Процитировано

0