The Blood Lipidome Fatty Acid Profile Predicts the Disease Risk and Clinical Phenotypes of Alzheimer's Disease: Associations from Two Prospective Cohort Studies DOI
Wenzheng Liu, Liangyu Huang,

Song Chi

и другие.

Опубликована: Янв. 1, 2024

Язык: Английский

The shift in the fatty acid composition of the circulating lipidome in Alzheimer's disease DOI Creative Commons
Farida Dakterzada, Mariona Jové,

José L. Cantero

и другие.

Alzheimer s & Dementia, Год журнала: 2024, Номер 20(5), С. 3322 - 3333

Опубликована: Март 27, 2024

Fatty acids (FAs) are the building blocks of complex lipids and signaling compounds; role lipidome fatty acid profile (LFA) in AD progression remains unclear.

Язык: Английский

Процитировано

5
Kai-Xin-San polysaccharides exert therapeutic effects on D-gal and Aβ25–35-induced AD rats by regulating gut microbiota and metabolic profile DOI

Zhinan Cai,

Min Zhang, Lifen Zhou

и другие.

International Journal of Biological Macromolecules, Год журнала: 2025, Номер 306, С. 141850 - 141850

Опубликована: Март 7, 2025

Язык: Английский

Процитировано

0
Identification of Key Fatty Acid Metabolism-Related Genes in Alzheimer’s Disease DOI
Bo Yan, Pan Liao, Wei Zhang

и другие.

Molecular Neurobiology, Год журнала: 2025, Номер unknown

Опубликована: Март 19, 2025

Язык: Английский

Процитировано

0
Hyperbaric Oxygen Improves Cognitive Impairment Induced by Hypoxia via Upregulating the Expression of Oleic Acid and MBOAT2 of Mice DOI Creative Commons
Zhen Li, Jun Fu, Kaiyuan Jiang

и другие.

Antioxidants, Год журнала: 2024, Номер 13(11), С. 1320 - 1320

Опубликована: Окт. 29, 2024

Cognitive impairment (CI) causes severe of brain function and quality life patients, which brings a great burden to society. Cerebral hypoxia is an important factor in the pathogenesis CI. Hyperbaric oxygen (HBO) therapy may mitigate hypoxia-induced CI, but its efficacy mechanisms are not fully understood. In this study, mice model CI induced by environment was established, then behavioral tests, pathological examination, metabolomic lipidomic analyses, molecular biology were used assess impact HBO on found alleviate damage mice. Metabolomic, lipidomic, analyses showed that increased levels oleic acid (OA) membrane-bound O-acyltransferase 2 (MBOAT2), thereby altering composition membrane phospholipids (PLs) reducing neuronal ferroptosis (FPT) interfere with cognitive vitro experiments confirmed OA MBOAT2 led PL remodeling mutually dependent manner, affecting cell resistance hypoxia-FPT. The results emphasized combined effect value for provided novel perspective treatment HBO.

Язык: Английский

Процитировано

0
The Blood Lipidome Fatty Acid Profile Predicts the Disease Risk and Clinical Phenotypes of Alzheimer's Disease: Associations from Two Prospective Cohort Studies DOI
Wenzheng Liu, Liangyu Huang,

Song Chi

и другие.

Опубликована: Янв. 1, 2024

Язык: Английский

Процитировано

0