International Journal of Biological Macromolecules,
Год журнала:
2025,
Номер
unknown, С. 142887 - 142887
Опубликована: Апрель 1, 2025
Amyloid-beta
(Aβ)
and
tubulin-associated
unit
(tau)
proteins
are
key
biomarkers
of
Alzheimer's
disease
(AD),
detectable
by
Positron
Emission
Tomography
(PET)
imaging
Cerebrospinal
Fluid
(CSF)
assays.
They
reflect
insoluble
fibrils
in
the
brain
soluble
monomers
cerebrospinal
fluid,
respectively.
PET
CSF
have
been
utilized
diagnosing
AD;
however,
their
incomplete
agreement
significantly
confounds
early
detection.
Additionally,
molecular
mechanisms
underlying
dynamics
AD
remain
elusive
yet
to
be
quantitatively
revealed.
To
answer
these
questions,
we
develop
a
multiscale
mathematical
model
that
characterizes
various
forms
biomarkers,
including
molecules
diffusive
across
regions,
brain.
Mathematical
modeling
enables
explanation
asynchronous
trajectory
biomarkers.
Our
captures
spatiotemporal
Aβ
tau
with
neurodegeneration
AD.
Simulation
results
demonstrate
PET-CSF
discordance
is
typical
stage
natural
history
protein
aggregation,
becoming
abnormal
before
onset
abnormality.
Furthermore,
correlation
analysis
reveals
more
strongly
associated
tau-PET
than
Aβ-PET.
These
findings
suggest
recognized
as
biomarker
at
AD,
while
suitable
for
assessment.
The
proposed
explains
neurobiological
factors
contributing
offers
valuable
tool
improving
detection
treatment
strategies
clinical
trials.
medRxiv (Cold Spring Harbor Laboratory),
Год журнала:
2025,
Номер
unknown
Опубликована: Март 13, 2025
Abstract
INTRODUCTION
Elevated
tau
is
temporally
proximal
to
dementia
onset
but
less
known
about
factors
influencing
T+
age
and
time
following
in
Alzheimer’s
disease.
We
used
sampled
iterative
localized
approximation
(SILA)
estimated
(ETOA)
investigate
associated
with
from
ADNI.
METHODS
Using
SILA-estimated
A+
ages
derived
18
F-Flortaucipir,
F-Florbetapir,
F-Florbetaben
PET
Cox
proportional
hazards
accelerated
failure
models,
we
analyzed
APOE
,
sex,
amyloid
burden,
age,
educational
attainment,
literacy
associations
ETOA
dementia.
RESULTS
Higher
amyloid,
-ε4,
lower
education,
younger
ETOA.
Older
higher
shorter
DISCUSSION
This
work
highlights
the
prognostic
value
of
need
better
characterize
contributing
AD.
Frontiers in Psychology,
Год журнала:
2025,
Номер
16
Опубликована: Апрель 2, 2025
A
healthy
brain
is
essential
for
independent
and
participatory
life.
Religion
may
play
a
key
role
in
health.
This
study
investigated
the
influence
of
religion
on
health
among
adults
United
Arab
Emirates
(UAE).
was
cross-sectional
UAE
based
Global
Brain
Health
Survey
(GBHS).
Information
demographics,
knowledge
beliefs
about
health,
religious
perceptions
practices
related
to
collected.
Data
were
summarized
using
frequencies
percentages.
Logistic
regression
analysis
used
identify
factors
associated
with
activities
attitudes
toward
results
are
presented
as
adjusted
odds
ratios
(OR)
95%
confidence
intervals
(CI).
total
887
participants
(65%
women)
included.
About
78%
women
73%
men
believed
that
strongly
influences
47%
reported
frequent
practice
their
Frequent
thoughts
one's
(OR
=
2.52,
CI
1.47-4.31),
engagements
33.42,
18.58-60.11),
being
married
0.46,
0.23-0.90),
having
had
COVID-19
0.51,
0.27-0.97)
purposeful
use
Our
found
significant
link
between
suggesting
faith-
spirituality-based
approaches
be
important
addressing
issues.
These
findings
highlight
need
programs
incorporate
improve
offering
practical
solutions
communities
healthcare
providers.
International Journal of Biological Macromolecules,
Год журнала:
2025,
Номер
unknown, С. 142887 - 142887
Опубликована: Апрель 1, 2025
Amyloid-beta
(Aβ)
and
tubulin-associated
unit
(tau)
proteins
are
key
biomarkers
of
Alzheimer's
disease
(AD),
detectable
by
Positron
Emission
Tomography
(PET)
imaging
Cerebrospinal
Fluid
(CSF)
assays.
They
reflect
insoluble
fibrils
in
the
brain
soluble
monomers
cerebrospinal
fluid,
respectively.
PET
CSF
have
been
utilized
diagnosing
AD;
however,
their
incomplete
agreement
significantly
confounds
early
detection.
Additionally,
molecular
mechanisms
underlying
dynamics
AD
remain
elusive
yet
to
be
quantitatively
revealed.
To
answer
these
questions,
we
develop
a
multiscale
mathematical
model
that
characterizes
various
forms
biomarkers,
including
molecules
diffusive
across
regions,
brain.
Mathematical
modeling
enables
explanation
asynchronous
trajectory
biomarkers.
Our
captures
spatiotemporal
Aβ
tau
with
neurodegeneration
AD.
Simulation
results
demonstrate
PET-CSF
discordance
is
typical
stage
natural
history
protein
aggregation,
becoming
abnormal
before
onset
abnormality.
Furthermore,
correlation
analysis
reveals
more
strongly
associated
tau-PET
than
Aβ-PET.
These
findings
suggest
recognized
as
biomarker
at
AD,
while
suitable
for
assessment.
The
proposed
explains
neurobiological
factors
contributing
offers
valuable
tool
improving
detection
treatment
strategies
clinical
trials.
