FDG-PET Detects Amygdala-Hippocampal Connection Volume and Heterogeneity in Alzheimer's Disease Progression
Research Square (Research Square),
Год журнала:
2025,
Номер
unknown
Опубликована: Март 27, 2025
Abstract
Objective
This
study
delves
into
the
potential
of
radiomics
to
identify
Alzheimer's
disease
(AD)
stages
and
monitor
its
progression
using
FDG
PET
images.
The
particular
objective
is
explore
tracking
a
reduced
meaningful
set
imaging
biomarkers
at
border
Hippocampus
Amygdala.
Method
Our
utilized
18F-FDG
scans
from
513
participants
spanning
three
Alzheimer’s
ADNI
database.
hippocampus,
amygdala,
entorhinal
cortex
consistently
emerged
as
key
regions
interest.
To
further
investigate
their
interconnectivity,
we
defined
hippocampus-amygdala
connecting
region
distance
transform
approach.
Next,
systematically
evaluated
eight
feature
selection
techniques
in
combination
with
six
classification
models
determine
most
effective
predictive
framework.
Finally,
conducted
Pearson
correlation
analysis
pinpoint
significant
features
for
AD
classification.
Results
connectivity
area
between
hippocampus
amygdala
demonstrated
superior
efficacy
diagnosing
AD.
Two
shape_MeshVolume_Right,
gldm_SmallDependenceLowGrayLevelEmphasis_left,
glrlm_ShortRunLowGrayLevelEmphasis_left
this
single
region,
could
predict
versus
Control
Normal
(CN)
individuals
ROC
AUC
=
0.91,
two
MCI
0.80,
shape_LeastAxisLength_left,
glszm_LargeAreaEmphasis_left
CN
0.69.
features'
mean
values
were
able
demonstrate
incremental
deterioration
groups
consecutive
statistical
significance
(p
<
0.05).
Conclusions
In
study,
radiomic
within
utility
progression.
By
limiting
these
specific
biomarkers,
offer
simple
but
clinically
relevant
approach
diagnosis
monitoring
role
early
detection
intervention.
Язык: Английский
Role of the amygdala and possible biomarkers in psychiatric disorders
NeuroMarkers.,
Год журнала:
2024,
Номер
unknown, С. 100032 - 100032
Опубликована: Дек. 1, 2024
Язык: Английский
Imaging the Unseen: Charting Amygdalar Tau’s Link to Affective Symptoms in Preclinical Alzheimer’s Disease
Biological Psychiatry Cognitive Neuroscience and Neuroimaging,
Год журнала:
2024,
Номер
9(12), С. 1236 - 1238
Опубликована: Дек. 1, 2024
Язык: Английский