Cognitive vulnerability to glucose fluctuations: A digital phenotype of neurodegeneration DOI Creative Commons
Luciana Mascarenhas Fonseca, Zoë Hawks, Michal Schnaider Beeri

и другие.

Alzheimer s & Dementia, Год журнала: 2025, Номер 21(2)

Опубликована: Фев. 1, 2025

Cognition is reduced at low and high glucose, reflecting cognitive vulnerability to glucose (CVG) fluctuations. The impact of fluctuations on the aging brain remains unclear. We examined whether CVG associated with plasma biomarkers Alzheimer's disease (AD) pathology neurodegeneration. Participants included N = 114 adults type 1 diabetes assessed for processing speed sustained attention using ecological momentary assessment (EMA) combined continuous monitoring (CGM). characterized associations between amyloid beta (Aβ) 42/40, phosphorylated tau (p-tau) 181 217, neurofilament light chain, glial fibrillary acidic protein. was all biomarkers, except Aβ 42/40. exhibited strong p-tau that persisted across covariate specifications. may be a useful digital phenotype AD. It unclear contributes versus arises from consider possible mechanisms linking long-term variability development neuropathology. Cognitive used investigate CVG's biomarkers. Associations remained significant covariates. discuss relating variability, cognition,

Язык: Английский

Cognitive vulnerability to glucose fluctuations: A digital phenotype of neurodegeneration DOI Creative Commons
Luciana Mascarenhas Fonseca, Zoë Hawks, Michal Schnaider Beeri

и другие.

Alzheimer s & Dementia, Год журнала: 2025, Номер 21(2)

Опубликована: Фев. 1, 2025

Cognition is reduced at low and high glucose, reflecting cognitive vulnerability to glucose (CVG) fluctuations. The impact of fluctuations on the aging brain remains unclear. We examined whether CVG associated with plasma biomarkers Alzheimer's disease (AD) pathology neurodegeneration. Participants included N = 114 adults type 1 diabetes assessed for processing speed sustained attention using ecological momentary assessment (EMA) combined continuous monitoring (CGM). characterized associations between amyloid beta (Aβ) 42/40, phosphorylated tau (p-tau) 181 217, neurofilament light chain, glial fibrillary acidic protein. was all biomarkers, except Aβ 42/40. exhibited strong p-tau that persisted across covariate specifications. may be a useful digital phenotype AD. It unclear contributes versus arises from consider possible mechanisms linking long-term variability development neuropathology. Cognitive used investigate CVG's biomarkers. Associations remained significant covariates. discuss relating variability, cognition,

Язык: Английский

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