Heterogeneous brain abnormalities in subjective cognitive decline converge on a common network and their transcriptional signature DOI Creative Commons
Huan Lan, Wei Liu, Chao Zuo

и другие.

Alzheimer s & Dementia, Год журнала: 2025, Номер 21(3)

Опубликована: Март 1, 2025

Abstract INTRODUCTION Subjective cognitive decline (SCD) is increasingly recognized as closely related to future Alzheimer's disease (AD). Numerous neuroimaging findings in SCD are inconsistent. We tested whether the various localize a common brain network. METHODS Using novel coordinate network mapping approach, we delineated damage networks that were functionally connected reported findings. then decoded these using microscale transcriptomic and chemo‐architectures psychological processes. RESULTS enrolled 45 studies comprising 2453 patients 3017 healthy controls. The identified largely localized somatosensory (SMN) default mode (DMN). Both robust perturbations of analyzed parameters an independent validation dataset. Neurobiology correlation analyses some key biological pathways neurotransmitters linked networks. DISCUSSION Our reconcile heterogeneous abnormalities provide richer neurobiological underpinning, which has implications for understanding with SCD. Highlights on reconciled framework. SCD‐related functional involves changes DMN, while structural mainly primary sensory areas. genes predominantly enriched processes synaptic structure, calcium ion binding, cellular metabolism. An ALE meta‐analysis was conducted comparison.

Язык: Английский

Heterogeneous brain abnormalities in subjective cognitive decline converge on a common network and their transcriptional signature DOI Creative Commons
Huan Lan, Wei Liu, Chao Zuo

и другие.

Alzheimer s & Dementia, Год журнала: 2025, Номер 21(3)

Опубликована: Март 1, 2025

Abstract INTRODUCTION Subjective cognitive decline (SCD) is increasingly recognized as closely related to future Alzheimer's disease (AD). Numerous neuroimaging findings in SCD are inconsistent. We tested whether the various localize a common brain network. METHODS Using novel coordinate network mapping approach, we delineated damage networks that were functionally connected reported findings. then decoded these using microscale transcriptomic and chemo‐architectures psychological processes. RESULTS enrolled 45 studies comprising 2453 patients 3017 healthy controls. The identified largely localized somatosensory (SMN) default mode (DMN). Both robust perturbations of analyzed parameters an independent validation dataset. Neurobiology correlation analyses some key biological pathways neurotransmitters linked networks. DISCUSSION Our reconcile heterogeneous abnormalities provide richer neurobiological underpinning, which has implications for understanding with SCD. Highlights on reconciled framework. SCD‐related functional involves changes DMN, while structural mainly primary sensory areas. genes predominantly enriched processes synaptic structure, calcium ion binding, cellular metabolism. An ALE meta‐analysis was conducted comparison.

Язык: Английский

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